U.S. Department of Health and Human Services

Laboratory of Bioorganic Chemistry

Kenneth A. Jacobson, Ph.D., Chief

​Resources

Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

Resource Name Description
Linking compounds useful for coupling carbohydrates to amine-containing carriers (U.S. Patent Number 5,952,454)

The present invention provides a method to couple a glycosyl donor to an amine-containing carrier or substrate material using as a spacer a compound of the general formula I: ##STR1## in which n and m are each independently an integer of from 1 to…

(Summary)
Novel conjugate vaccine process, cholera vaccine (U.S. Patent Number 61/507,054)

A new conjugate vaccine for cholera has been developed. The invention includes a new method to conjugate the O-specific polysaccharide-core part of the bacterial lipopolysaccharide and protein subcomponents. Conventional technology has entailed…

(Summary)
Adenosine receptor agonists, partial agonists, and antagonists (U.S. Patent Number 13/479,973)
NIDDK announces the availability of  a highly selective A1 adenosine receptor (AR) agonist.  This receptor is neuroprotective in ischemic and epileptic models.  The A1AR-selective full agonist MRS5474  displayed anticonvulsant activity in vivo in a…
(Summary)
Antimicrobial Compounds that Inhibit FTSZ Protein (U.S. Patent Number 61/446,978)

This invention, offered for licensing and commercial development, relates to a new class of naturally occurring antimicrobial compounds called Chrysophaetins, and to their synthetic analogues. Isolated from an alga species, the mechanism of action of…

(Summary)
PNA-Detection of Pathogens (U.S. Patent Number 13/592,490)

The laboratory of Daniel Appella, PhD. has developed a prototype HIV testing kit that employs a peptide nucleic acid probe to capture HIV RNA recovered from patient blood.  The probe targets a highly conserved segment of the Gag sequence.   Initial…

(Summary)
Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands (U.S. Patent Number EP 2569328 A2)

The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising:

  • (i) from 2 to 50 nucleobase subunits and
  • (ii) one or more gamma substituents.

The PNA strands are complementary to at least a…

(Summary)
Anti-HIV Acylthiol & Thioether prodrugs (U.S. Patent Number 12/414,321)
These inventions provide the compositions, pharmaceutical carrier, and usages of the new Acylthiols (E-329-2000 family) and Thioether pro-drug (E-177-2010 family) compounds in treatment of retroviral infections such as HIV. These compounds target the…
(Summary)
M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity. (Mutant Mouse: M3 Muscarinic receptor KO (Chrm3 tm1Jwe) Mouse)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…

(Summary)
M1 Muscarinic receptor KO (Chrm1 tm1Jwe) Mouse (Mutant Mouse: Chrm1 (Cholinergic Receptor, muscarinic 1))

M1 Muscarinic Receptor Knockout: support involvement in cognitive processes.

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to…

(Summary)
M2 Muscarinic receptor KO (Chrm2 tm1Jwe) Mouse (Mutant Mouse: Chrm2)

M2 Muscarinic Receptor Knockout: role in learning and memory, and mediating analgesic effectsof muscarinic agonists

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…

(Summary)
M4 Muscarinic receptor KO (Chrm4 tm1Jwe) Mouse (Mutant Mouse: Chrm4)

M4 Muscarinic Receptor Knockout: Activation of M4R may reduce the reinforcing effect of drugs of abuse, and contribute to the analgesic effects observed after administration of muscarinic agonists.

The five Muscarinic Acetylcholine (ACh) receptors are…

(Summary)
M5 Muscarinic receptor KO (Chrm5 tm1Jwe) Mouse (Mutant Mouse: Chrm5)

M5 Muscarinic Receptor Knockout: Deficiency of M5Rs reduces drug-seeking behavior.

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively…

(Summary)
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Clinical Trials

Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.

Study Title
There are no associated clinical trials.
Search for more clinical trials at ClinicalTrials.gov