U.S. Department of Health and Human Services

Laboratory of Biological Modeling

Arthur Sherman, Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Göbel B, Sanghvi A, Hall KD. Quantifying energy intake changes during obesity pharmacotherapy. Obesity (Silver Spring). 2014 Jun 24; 22 (2014 Jun 24; 10; 22):2105-8. [Full Text/Abstract]
Brady I, Hall KD. Dispatch from the field: is mathematical modeling applicable to obesity treatment in the real world?. Obesity (Silver Spring). 2014 Jun 4; 22 (2014 Jun 4; 9; 22):1939-41. [Full Text/Abstract]
Müller MJ, Baracos V, Bosy-Westphal A, Dulloo AG, Eckel J, Fearon KC, Hall KD, Pietrobelli A, Sørensen TI, Speakman J, Trayhurn P, Visser M, Heymsfield SB. Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany. Obes Rev. 2014 Aug; 15 (8; 2014 Aug; 15):640-56. [Full Text/Abstract]
Lee JJ, Chow CC. Conditions for the validity of SNP-based heritability estimation. Hum Genet. 2014 Aug; 133 (133; 8; 2014 Aug):1011-22. [Full Text/Abstract]
Chow CC, Hall KD. Short and long-term energy intake patterns and their implications for human body weight regulation. Physiol Behav. 2014 Jul; 134 (134; 2014 Jul):60-5. [Full Text/Abstract]
Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr. Research Resource: Modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Mol Endocrinol. 2014 Jul; 28 (28; 7; 2014 Jul):me20141069. [Full Text/Abstract]
Hall KD, Hammond RA, Rahmandad H. Dynamic Interplay Among Homeostatic, Hedonic, and Cognitive Feedback Circuits Regulating Body Weight. Am J Public Health. 2014 Jul; 104 (104; 7; 2014 Jul):1169-75. [Full Text/Abstract]
Kong AP, Yang X, Luk A, Cheung KK, Ma RC, So WY, Ho CS, Chan MH, Ozaki R, Chow CC, Brown N, Chan JC. Hypoglycaemia, chronic kidney disease and death in type 2 diabetes: the Hong Kong diabetes registry. BMC Endocr Disord. 2014 Jun 13; 14 (14; 2014 Jun 13):48. [Full Text/Abstract]
Chan JC, Sui Y, Oldenburg B, Zhang Y, Chung HH, Goggins W, Au S, Brown N, Ozaki R, Wong RY, Ko GT, Fisher E, JADE and PEARL Project Team. Effects of telephone-based peer support in patients with type 2 diabetes mellitus receiving integrated care: a randomized clinical trial. JAMA Intern Med. 2014 Jun; 174 (6; 174; 2014 Jun):972-81. [Full Text/Abstract]
Kong AP, Yang X, So WY, Luk A, Ma RC, Ozaki R, Cheung K, Lee HM, Yu L, Xu G, Chow CC, Chan JC. Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes. BMC Med. 2014 May 13; 12 (12; 1; 2014 May 13):76. [Full Text/Abstract]
Wang X, Chow CC, Yao X, Ko GT, Cockram CS, Kwok HK, Zhang J, Tang NL. The predisposition to thyrotoxic periodic paralysis (TPP) is due to a genetic variant in the inward-rectifying potassium channel, KCNJ2. Clin Endocrinol (Oxf). 2014 May; 80 (80; 2014 May; 5):770-1. [Full Text/Abstract]
Periwal V, Gaillard JR, Needleman L, Doria C. Mathematical model of liver regeneration in human live donors. J Cell Physiol. 2014 May; 229 (229; 2014 May; 5):599-606. [Full Text/Abstract]
Kong AP, Yang X, Luk A, Ma RC, So WY, Ozaki R, Ting R, Cheung K, Ho CS, Chan MH, Chow CC, Chan JC. Severe hypoglycemia identifies vulnerable patients with type 2 diabetes at risk for premature death and all-site cancer: the Hong Kong diabetes registry. Diabetes Care. 2014 Apr; 37 (37; 4; 2014 Apr):1024-31. [Full Text/Abstract]
Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr. A kinase-independent activity of cdk9 modulates glucocorticoid receptor-mediated gene induction. Biochemistry. 2014 Mar 25; 53 (2014 Mar 25; 53; 11):1753-67. [Full Text/Abstract]
Simmons WK, Rapuano KM, Ingeholm JE, Avery J, Kallman S, Hall KD, Martin A. The ventral pallidum and orbitofrontal cortex support food pleasantness inferences. Brain Struct Funct. 2014 Mar; 219 (2014 Mar; 219; 2):473-83. [Full Text/Abstract]
Shreif Z, Periwal V. A network characteristic that correlates environmental and genetic robustness. PLoS Comput Biol. 2014 Feb; 10 (2; 2014 Feb; 10):e1003474. [Full Text/Abstract]
Ma RC, So WY, Tam CH, Luk AO, Ho JS, Wang Y, Lam VK, Lee HM, Kong AP, Tong PC, Xu G, Chow CC, Ng MC, Yang XL, Chan JC. Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes. Diabetes Res Clin Pract. 2014 Feb; 103 (2; 2014 Feb; 103):328-37. [Full Text/Abstract]
Hall KD, Chow CC. Why is the 3500 kcal per pound weight loss rule wrong?. Int J Obes (Lond). 2013 Dec; 37 (2013 Dec; 37; 12):1614. [Full Text/Abstract]
Simmons WK, Rapuano KM, Kallman SJ, Ingeholm JE, Miller B, Gotts SJ, Avery JA, Hall KD, Martin A. Category-specific integration of homeostatic signals in caudal but not rostral human insula. Nat Neurosci. 2013 Nov; 16 (16; 2013 Nov; 11):1551-2. [Full Text/Abstract]
Hall KD, Butte NF, Swinburn BA, Chow CC. Dynamics of childhood growth and obesity: development and validation of a quantitative mathematical model. Lancet Diabetes Endocrinol. 2013 Oct; 1 (2013 Oct; 2; 1):97-105. [Full Text/Abstract]
Wang X, Misawa R, Zielinski MC, Cowen P, Jo J, Periwal V, Ricordi C, Khan A, Szust J, Shen J, Millis JM, Witkowski P, Hara M. Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One. 2013; 8 (6; 8; 2013):e67454. [Full Text/Abstract]
Jo J, Hörnblad A, Kilimnik G, Hara M, Ahlgren U, Periwal V. The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model. Phys Biol. 2013 Jun; 10 (10; 3; 2013 Jun):036009. [Full Text/Abstract]
Hall KD. Diet versus exercise in "the biggest loser" weight loss competition. Obesity (Silver Spring). 2013 May; 21 (2013 May; 21; 5):957-9. [Full Text/Abstract]
Adler-Wailes DC, Periwal V, Ali AH, Brady SM, McDuffie JR, Uwaifo GI, Tanofsky-Kraff M, Salaita CG, Hubbard VS, Reynolds JC, Chow CC, Sumner AE, Yanovski JA. Sex-associated differences in free fatty acid flux of obese adolescents. J Clin Endocrinol Metab. 2013 Apr; 98 (98; 4; 2013 Apr):1676-84. [Full Text/Abstract]
Li Y, Periwal V. Synergy in free radical generation is blunted by high-fat diet induced alterations in skeletal muscle mitochondrial metabolism. Biophys J. 2013 Mar 5; 104 (104; 5; 2013 Mar 5):1127-41. [Full Text/Abstract]
Hall KD. Metabolism of mice and men: mathematical modeling of body weight dynamics. Curr Opin Clin Nutr Metab Care. 2012 Sep; 15 (2012 Sep; 15; 5):418-23. [Full Text/Abstract]
Hall KD. Modeling metabolic adaptations and energy regulation in humans. Annu Rev Nutr. 2012 Aug 21; 32 (32; 2012 Aug 21):35-54. [Full Text/Abstract]
Osinga HM, Sherman A, Tsaneva-Atanasova K. CROSS-CURRENTS BETWEEN BIOLOGY AND MATHEMATICS: THE CODIMENSION OF PSEUDO-PLATEAU BURSTING. Discrete Contin Dyn Syst Ser A. 2012 Aug; 32 (2012 Aug; 32; 8):2853-2877. [Full Text/Abstract]
Johannsen DL, Knuth ND, Huizenga R, Rood JC, Ravussin E, Hall KD. Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab. 2012 Jul; 97 (7; 97; 2012 Jul):2489-96. [Full Text/Abstract]
Khadra A, Yan Z, Coddou C, Tomić M, Sherman A, Stojilkovic SS. Gating properties of the P2X2a and P2X2b receptor channels: experiments and mathematical modeling. J Gen Physiol. 2012 May; 139 (2012 May; 139; 5):333-48. [Full Text/Abstract]
Hall KD, Heymsfield SB, Kemnitz JW, Klein S, Schoeller DA, Speakman JR. Energy balance and its components: implications for body weight regulation. Am J Clin Nutr. 2012 Apr; 95 (95; 4; 2012 Apr):989-94. [Full Text/Abstract]
Heuett WJ, Miller BV 3rd, Racette SB, Holloszy JO, Chow CC, Periwal V. Bayesian functional integral method for inferring continuous data from discrete measurements. Biophys J. 2012 Feb 8; 102 (102; 2012 Feb 8; 3):399-406. [Full Text/Abstract]
Vattikuti S, Guo J, Chow CC. Heritability and genetic correlations explained by common SNPs for metabolic syndrome traits. PLoS Genet. 2012; 8 (2012; 8; 3):e1002637. [Full Text/Abstract]
Gotts SJ, Chow CC, Martin A. Repetition Priming and Repetition Suppression: A Case for Enhanced Efficiency Through Neural Synchronization. Cogn Neurosci. 2012; 3 (3-4; 2012; 3):227-237. [Full Text/Abstract]
Dougherty EJ, Guo C, Simons SS Jr, Chow CC. Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification. PLoS One. 2012; 7 (2012; 7; 1):e30225. [Full Text/Abstract]
Lin BH, Smith TA, Lee JY, Hall KD. Measuring weight outcomes for obesity intervention strategies: the case of a sugar-sweetened beverage tax. Econ Hum Biol. 2011 Dec; 9 (4; 2011 Dec; 9):329-41. [Full Text/Abstract]
Buice MA, Chow CC. Effective stochastic behavior in dynamical systems with incomplete information. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov; 84 (2011 Nov; 5 Pt 1; 84):051120. [Full Text/Abstract]
Seely J, Chow CC. Role of mutual inhibition in binocular rivalry. J Neurophysiol. 2011 Nov; 106 (106; 2011 Nov; 5):2136-50. [Full Text/Abstract]
Hall KD, Sacks G, Chandramohan D, Chow CC, Wang YC, Gortmaker SL, Swinburn BA. Quantification of the effect of energy imbalance on bodyweight. Lancet. 2011 Aug 27; 378 (378; 2011 Aug 27; 9793):826-37. [Full Text/Abstract]
Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, Gortmaker SL. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011 Aug 27; 378 (378; 2011 Aug 27; 9793):804-14. [Full Text/Abstract]
Jo J, Kilimnik G, Kim A, Guo C, Periwal V, Hara M. Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures. Biophys J. 2011 Aug 3; 101 (2011 Aug 3; 101; 3):565-74. [Full Text/Abstract]
Chow CC, Periwal V, Csako G, Ricks M, Courville AB, Miller BV 3rd, Vega GL, Sumner AE. Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. J Clin Endocrinol Metab. 2011 Aug; 96 (8; 2011 Aug; 96):2456-63. [Full Text/Abstract]
Hall KD, Chow CC. Estimating changes in free-living energy intake and its confidence interval. Am J Clin Nutr. 2011 Jul; 94 (94; 2011 Jul; 1):66-74. [Full Text/Abstract]
Khadra A, Pietropaolo M, Nepom GT, Sherman A. Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction. PLoS One. 2011 May 10; 6 (6; 2011 May 10; 5):e14796. [Full Text/Abstract]
Guo J, Hall KD. Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice. PLoS One. 2011 Jan 5; 6 (2011 Jan 5; 6; 1):e15961. [Full Text/Abstract]
Fatakia SN, Costanzi S, Chow CC. Molecular evolution of the transmembrane domains of G protein-coupled receptors. PLoS One. 2011; 6 (2011; 6; 11):e27813. [Full Text/Abstract]
Yan Z, Khadra A, Li S, Tomic M, Sherman A, Stojilkovic SS. Experimental characterization and mathematical modeling of P2X7 receptor channel gating. J Neurosci. 2010 Oct 20; 30 (30; 2010 Oct 20; 42):14213-24. [Full Text/Abstract]
Peercy BE, Sherman AS. How pancreatic beta-cells discriminate long and short timescale cAMP signals. Biophys J. 2010 Jul 21; 99 (2010 Jul 21; 2; 99):398-406. [Full Text/Abstract]
Merrins MJ, Fendler B, Zhang M, Sherman A, Bertram R, Satin LS. Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations. Biophys J. 2010 Jul 7; 99 (2010 Jul 7; 99; 1):76-84. [Full Text/Abstract]
Ong KM, Blackford JA Jr, Kagan BL, Simons SS Jr, Chow CC. A theoretical framework for gene induction and experimental comparisons. Proc Natl Acad Sci U S A. 2010 Apr 13; 107 (107; 2010 Apr 13; 15):7107-12. [Full Text/Abstract]