U.S. Department of Health and Human Services

Laboratory of Biological Modeling

Arthur Sherman, Ph.D., Chief

​Research Images

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TitleDescriptionImage
Pancreatic Beta Cell Signaling PathwaysThis schematic provides an illustration of some of the pathways included in our models. See Sherman, Mathematical Biosci. 227:12-19, 2007 for details.Pancreatic Beta Cell Signaling PathwaysEnlarge
Sliding barsThis schematic model depicts changes in islet activity due to step increases in glucose concentration. A sliding threshold representation of the dual oscillator model dynamics is depicted left, with measured islet Ca2+ concentration and corresponding model simulations, right. The models are from Bertram et al, Am. J. Physiol. Endocrinol. Metab. 293:890-900. Sliding barsEnlarge
Cover Art, J. Gen. Physiol., July, 2011The image depicts bifurcation diagrams and time courses of four types of bursting oscillations made by varying parameters in a simplified Chay-Keizer model. Clockwise from top left the diagrams depict a plateau without spikes, a square-wave bursting (beta cell pattern), a pseudo-plateau bursting (pituitary somatotroph pattern), and a parabolic bursting (like R-15 neuron of Aplysia).Cover Art, J. Gen. Physiol., July, 2011Enlarge