The Laboratory investigates developmentally programmed gene expression, functional genomics, chromatin and epigenetic modifications, particularly as they relate to cellular differentiation and organismal development. These processes regulate gene expression, signal transduction in multi-cellular organisms, chemotaxis, sex determination, fertilization, and early development.
Scientists within the laboratory utilize a variety of simple and multicellular model systems, including cultured cells, Dictyostelium, Drosophila, and mice. Studies exploit modern cell and molecular experimental techniques including genetic mutation, transgenesis, state-of-the-art imaging, and computational analysis of genome-wide datasets that include gene expression profiling and analysis of chromatin organization.
The primary goal of the research conducted in the Laboratory is to gain insight into the molecular mechanisms of normal biology, disruption of which leads to abnormal cell differentiation and development. Basic research into molecular mechanisms of development holds the promise of discovering new avenues for therapeutic intervention in disruptions of human biology that cause disease.