U.S. Department of Health and Human Services

Cell Biochemistry Section

John A. Hanover, Ph.D., Chief

​Research Images

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TitleDescriptionImage
The Hexosamine Signaling PathwayThis image depicts the Nutrient Sensing Hexosamine signaling pathway terminating in O-GlcNAc addition and removal. This pathway may be deregulated in human diseases such as diabetes.Enlarge
Calmodulin-Dependent Nuclear ImportEnlarge
OGT isoforms are differentially targeted to nucleus and mitochondria in Hela cellsUsing an antisera to OGT (green) and mitotracker (red), OGT isoforms were shown to be present in nucleus and mitochondria.Enlarge
Structure of the TPR domain of OGT has similarities to Importin alphaEnlarge
O-GlcNAc cycling modulates insulin signaling and Dauer in C. elegansIn C. elegans, insulin-like signaling regulates longevity, stress response, and the entry into the diapause state termed dauer. Knockout of ogt-1 leads to reduced dauer formation (insulin hypersensitivity), while knockout of oga-1 results in enhanced dauer formation (insulin resistance).Enlarge
Hexosamine Signaling and TaopathyThe expression of mutated human tau (V337M) in C. elegans causes a severe uncoordinated motion (unc) phenotype associated with neuronal cell death. When this mutation is crossed to ogt-1(ok430), this phenotype is largely corrected.Enlarge
Ran and CalmodulinEnlarge