U.S. Department of Health and Human Services

Laboratory of Cell and Molecular Biology

John A. Hanover, Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Adihe Lokanga R, Zhao XN, Entezam A, Usdin K. X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion. Hum Mol Genet. 2014 Sep 15; 23 (23; 2014 Sep 15; 18):4985-94. [Full Text/Abstract]
Abd-Elmoniem KZ, Bakalov VK, Matta JR, Muldoon N, Hanover JA, Bondy CA, Gharib AM. X Chromosome Parental Origin and Aortic Stiffness in Turner Syndrome. Clin Endocrinol (Oxf). 2014 Sep; 81 (81; 3; 2014 Sep):467-70. [Full Text/Abstract]
Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE. A dynamin mutant defines a superconstricted prefission state. Cell Rep. 2014 Aug 7; 8 (8; 2014 Aug 7; 3):734-42. [Full Text/Abstract]
Chen Q, Boulanger A, Hinton DM, Stibitz S. Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in Bordetella pertussis. Mol Microbiol. 2014 Aug; 93 (93; 2014 Aug; 4):748-58. [Full Text/Abstract]
Kumari D, Usdin K. Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription. Hum Mol Genet. 2014 Jul 23; 23 (23; 2014 Jul 23; 24):6575-83. [Full Text/Abstract]
Prinz WA. Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics. J Cell Biol. 2014 Jun 23; 205 (2014 Jun 23; 6; 205):759-69. [Full Text/Abstract]
Stichelen SO, Abramowitz LK, Hanover JA. X Marks the Spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?. Biochem Biophys Res Commun. 2014 Jun 21; 453 (453; 2; 2014 Jun 21):201-207. [Full Text/Abstract]
Kim EJ, Abramowitz LK, Bond MR, Love DC, Ahn JS, Kang DW, Leucke HF, Kang DW, Hanover JA. Versatile O-GlcNAc Transferase Assay for High-throughput Identification of Enzyme Variants, Substrates, and Inhibitors. Bioconjug Chem. 2014 Jun 18; 25 (25; 6; 2014 Jun 18):1025-30. [Full Text/Abstract]
Yudkin D, Hayward BE, Aladjem MI, Kumari D, Usdin K. Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome. Hum Mol Genet. 2014 Jun 1; 23 (2014 Jun 1; 23; 11):2940-52. [Full Text/Abstract]
Harwood KR, Hanover JA. Nutrient-driven O-GlcNAc cycling - think globally but act locally. J Cell Sci. 2014 May 1; 127 (127; 2014 May 1; Pt 9):1857-67. [Full Text/Abstract]
Chen J, Miller BF, Furano AV. Repair of naturally occurring mismatches can induce mutations in flanking DNA. Elife. 2014 Apr 29; 3 (3; 2014 Apr 29):e02001. [Full Text/Abstract]
Zhao XN, Usdin K. Gender and Cell-Type Specific Effects of the Transcription Coupled Repair Protein, ERCC6/CSB, on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders. Hum Mutat. 2014 Mar; 35 (2014 Mar; 35; 3):341-9. [Full Text/Abstract]
Rahman MM, Rosu S, Joseph-Strauss D, Cohen-Fix O. Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2014 Feb 18; 111 (2014 Feb 18; 7; 111):2602-7. [Full Text/Abstract]
Heald R, Cohen-Fix O. Morphology and function of membrane-bound organelles. Curr Opin Cell Biol. 2014 Feb; 26 (2014 Feb; 26):79-86. [Full Text/Abstract]
Prinz WA. The lipid trade. Nat Rev Mol Cell Biol. 2014 Feb; 15 (2; 15; 2014 Feb):79. [Full Text/Abstract]
Lokanga RA, Zhao XN, Usdin K. The mismatch repair protein MSH2 is rate limiting for repeat expansion in a fragile X premutation mouse model. Hum Mutat. 2014 Jan; 35 (35; 2014 Jan; 1):129-36. [Full Text/Abstract]
Sarker MM, Zhou M, Rameshwar P, Hanover JA. Functions and Roles of Proteins: Diabetes as a Paradigm. Prog Biophys Mol Biol. 2014 Jan; 114 (2014 Jan; 114; 1):2-7. [Full Text/Abstract]
Sundborger AC, Hinshaw JE. Regulating dynamin dynamics during endocytosis. F1000Prime Rep. 2014; 6 (6; 2014):85. [Full Text/Abstract]
Hsieh ML, James TD, Knipling L, Waddell MB, White S, Hinton DM. Architecture of the Bacteriophage T4 Activator MotA/Promoter DNA Interaction During Sigma Appropriation. J Biol Chem. 2013 Sep 20; 288 (38; 288; 2013 Sep 20):27607-18. [Full Text/Abstract]
Boulanger A, Chen Q, Hinton DM, Stibitz S. In vivo phosphorylation dynamics of the Bordetella pertussis virulence-controlling response regulator BvgA. Mol Microbiol. 2013 Apr; 88 (2013 Apr; 1; 88):156-72. [Full Text/Abstract]
Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum Mol Genet. 2013 Mar 15; 22 (2013 Mar 15; 6; 22):1180-92. [Full Text/Abstract]
Lokanga RA, Entezam A, Kumari D, Yudkin D, Qin M, Smith CB, Usdin K. Somatic expansion in mouse and human carriers of fragile X premutation alleles. Hum Mutat. 2013 Jan; 34 (34; 1; 2013 Jan):157-66. [Full Text/Abstract]
Decker KB, Hinton DM. Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases. Annu Rev Microbiol. 2013; 67 (67; 2013):113-39. [Full Text/Abstract]
Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci. 2012 Oct 15; 125 (2012 Oct 15; Pt 20; 125):4791-9. [Full Text/Abstract]
Walters AD, Bommakanti A, Cohen-Fix O. Shaping the nucleus: factors and forces. J Cell Biochem. 2012 Sep; 113 (113; 2012 Sep; 9):2813-21. [Full Text/Abstract]
Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem. 2012 Jul 6; 287 (28; 287; 2012 Jul 6):23549-61. [Full Text/Abstract]
Decker KB, James TD, Stibitz S, Hinton DM. The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA. Microbiology. 2012 Jul; 158 (Pt 7; 2012 Jul; 158):1665-76. [Full Text/Abstract]
Kumari D, Lokanga R, Yudkin D, Zhao XN, Usdin K. Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia. Biochim Biophys Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819):802-10. [Full Text/Abstract]
Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, Cohen-Fix O. The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. Curr Biol. 2012 Jun 19; 22 (2012 Jun 19; 12; 22):1128-33. [Full Text/Abstract]
Hoffman GE, Le WW, Entezam A, Otsuka N, Tong ZB, Nelson L, Flaws JA, McDonald JH, Jafar S, Usdin K. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. J Histochem Cytochem. 2012 Jun; 60 (2012 Jun; 6; 60):439-56. [Full Text/Abstract]
Dolezal D, Jones CE, Lai X, Brister JR, Mueser TC, Nossal NG, Hinton DM. Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA. J Biol Chem. 2012 May 25; 287 (2012 May 25; 287; 22):18596-607. [Full Text/Abstract]
Joseph-Strauss D, Gorjánácz M, Santarella-Mellwig R, Voronina E, Audhya A, Cohen-Fix O. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Dev Biol. 2012 May 15; 365 (2012 May 15; 2; 365):445-57. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol. 2012 Apr 23; 13 (2012 Apr 23; 13; 5):312-21. [Full Text/Abstract]
Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA. The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol. 2012 Apr 16; 197 (2012 Apr 16; 197; 2):209-17. [Full Text/Abstract]
Cohen-Fix O. Orna Cohen-Fix: playing with nuclear morphology. Interview by Caitlin Sedwick. J Cell Biol. 2012 Mar 5; 196 (2012 Mar 5; 196; 5):550-1. [Full Text/Abstract]
Kumari D, Usdin K. Is Friedreich ataxia an epigenetic disorder?. Clin Epigenetics. 2012 Jan 30; 4 (4; 2012 Jan 30; 1):2. [Full Text/Abstract]
Callahan KE, Hickman AB, Jones CE, Ghirlando R, Furano AV. Polymerization and nucleic acid-binding properties of human L1 ORF1 protein. Nucleic Acids Res. 2012 Jan; 40 (40; 2; 2012 Jan):813-27. [Full Text/Abstract]
Toulmay A, Prinz WA. A conserved membrane-binding domain targets proteins to organelle contact sites. J Cell Sci. 2012 Jan 1; 125 (Pt 1; 125; 2012 Jan 1):49-58. [Full Text/Abstract]
Bonocora RP, Decker PK, Glass S, Knipling L, Hinton DM. Bacteriophage T4 MotA activator and the β-flap tip of RNA polymerase target the same set of σ70 carboxyl-terminal residues. J Biol Chem. 2011 Nov 11; 286 (2011 Nov 11; 45; 286):39290-6. [Full Text/Abstract]
Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 2011 Sep 30; 147 (147; 2011 Sep 30; 1):209-22. [Full Text/Abstract]
Keembiyehetty CN, Krzeslak A, Love DC, Hanover JA. A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. J Cell Sci. 2011 Aug 15; 124 (124; 2011 Aug 15; Pt 16):2851-60. [Full Text/Abstract]
Toulmay A, Prinz WA. Lipid transfer and signaling at organelle contact sites: the tip of the iceberg. Curr Opin Cell Biol. 2011 Aug; 23 (23; 4; 2011 Aug):458-63. [Full Text/Abstract]
Decker KB, Chen Q, Hsieh ML, Boucher P, Stibitz S, Hinton DM. Different requirements for σ Region 4 in BvgA activation of the Bordetella pertussis promoters P(fim3) and P(fhaB). J Mol Biol. 2011 Jun 24; 409 (2011 Jun 24; 409; 5):692-709. [Full Text/Abstract]
Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW. O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics. 2011 Jun; 188 (188; 2; 2011 Jun):369-82. [Full Text/Abstract]
Qin M, Entezam A, Usdin K, Huang T, Liu ZH, Hoffman GE, Smith CB. A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis. Neurobiol Dis. 2011 Apr; 42 (2011 Apr; 42; 1):85-98. [Full Text/Abstract]
Kumari D, Biacsi RE, Usdin K. Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells. J Biol Chem. 2011 Feb 11; 286 (6; 2011 Feb 11; 286):4209-15. [Full Text/Abstract]
Hanover JA. A versatile sugar transferase makes the cut. Cell. 2011 Feb 4; 144 (144; 3; 2011 Feb 4):321-3. [Full Text/Abstract]
Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol. 2011 Jan; 18 (2011 Jan; 1; 18):20-6. [Full Text/Abstract]
Sundborger A, Soderblom C, Vorontsova O, Evergren E, Hinshaw JE, Shupliakov O. An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling. J Cell Sci. 2011 Jan 1; 124 (124; Pt 1; 2011 Jan 1):133-43. [Full Text/Abstract]
Hanover JA. Epigenetics gets sweeter: O-GlcNAc joins the "histone code". Chem Biol. 2010 Dec 22; 17 (17; 12; 2010 Dec 22):1272-4. [Full Text/Abstract]