U.S. Department of Health and Human Services

Laboratory of Cell and Molecular Biology

John A. Hanover, Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice.Hum. Mol. Genet. 2013 Mar 15; 22 (2013 Mar 15; 6; 22) :1180-92. [Full Text/Abstract]
Lokanga RA, Entezam A, Kumari D, Yudkin D, Qin M, Smith CB, Usdin K. Somatic expansion in mouse and human carriers of fragile X premutation alleles.Hum. Mutat. 2013 Jan; 34 (34; 1; 2013 Jan) :157-66. [Full Text/Abstract]
Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae.J. Cell. Sci. 2012 Oct 15; 125 (2012 Oct 15; Pt 20; 125) :4791-9. [Full Text/Abstract]
Walters AD, Bommakanti A, Cohen-Fix O. Shaping the nucleus: factors and forces.J. Cell. Biochem. 2012 Sep; 113 (113; 2012 Sep; 9) :2813-21. [Full Text/Abstract]
Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo.J. Biol. Chem. 2012 Jul 6; 287 (28; 287; 2012 Jul 6) :23549-61. [Full Text/Abstract]
Decker KB, James TD, Stibitz S, Hinton DM. The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA.Microbiology (Reading, Engl.). 2012 Jul; 158 (Pt 7; 2012 Jul; 158) :1665-76. [Full Text/Abstract]
Kumari D, Lokanga R, Yudkin D, Zhao XN, Usdin K. Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.Biochim. Biophys. Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819) :802-10. [Full Text/Abstract]
Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, Cohen-Fix O. The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay.Curr. Biol. 2012 Jun 19; 22 (2012 Jun 19; 12; 22) :1128-33. [Full Text/Abstract]
Hoffman GE, Le WW, Entezam A, Otsuka N, Tong ZB, Nelson L, Flaws JA, McDonald JH, Jafar S, Usdin K. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency.J. Histochem. Cytochem. 2012 Jun; 60 (2012 Jun; 6; 60) :439-56. [Full Text/Abstract]
Dolezal D, Jones CE, Lai X, Brister JR, Mueser TC, Nossal NG, Hinton DM. Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA.J. Biol. Chem. 2012 May 25; 287 (2012 May 25; 287; 22) :18596-607. [Full Text/Abstract]
Joseph-Strauss D, Gorjánácz M, Santarella-Mellwig R, Voronina E, Audhya A, Cohen-Fix O. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos.Dev. Biol. 2012 May 15; 365 (2012 May 15; 2; 365) :445-57. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation.Nat. Rev. Mol. Cell Biol. 2012 Apr 23; 13 (2012 Apr 23; 13; 5) :312-21. [Full Text/Abstract]
Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA. The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.J. Cell Biol. 2012 Apr 16; 197 (2012 Apr 16; 197; 2) :209-17. [Full Text/Abstract]
Cohen-Fix O. Orna Cohen-Fix: playing with nuclear morphology. Interview by Caitlin Sedwick.J. Cell Biol. 2012 Mar 5; 196 (2012 Mar 5; 196; 5) :550-1. [Full Text/Abstract]
Kumari D, Usdin K. Is Friedreich ataxia an epigenetic disorder?Clin Epigenetics. 2012 Jan 30; 4 (4; 2012 Jan 30; 1) :2. [Full Text/Abstract]
Callahan KE, Hickman AB, Jones CE, Ghirlando R, Furano AV. Polymerization and nucleic acid-binding properties of human L1 ORF1 protein.Nucleic Acids Res. 2012 Jan; 40 (40; 2; 2012 Jan) :813-27. [Full Text/Abstract]
Toulmay A, Prinz WA. A conserved membrane-binding domain targets proteins to organelle contact sites.J. Cell. Sci. 2012 Jan 1; 125 (Pt 1; 125; 2012 Jan 1) :49-58. [Full Text/Abstract]
Bonocora RP, Decker PK, Glass S, Knipling L, Hinton DM. Bacteriophage T4 MotA activator and the β-flap tip of RNA polymerase target the same set of σ70 carboxyl-terminal residues.J. Biol. Chem. 2011 Nov 11; 286 (2011 Nov 11; 45; 286) :39290-6. [Full Text/Abstract]
Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.Cell. 2011 Sep 30; 147 (147; 2011 Sep 30; 1) :209-22. [Full Text/Abstract]
Keembiyehetty CN, Krzeslak A, Love DC, Hanover JA. A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome.J. Cell. Sci. 2011 Aug 15; 124 (124; 2011 Aug 15; Pt 16) :2851-60. [Full Text/Abstract]
Toulmay A, Prinz WA. Lipid transfer and signaling at organelle contact sites: the tip of the iceberg.Curr. Opin. Cell Biol. 2011 Aug; 23 (23; 4; 2011 Aug) :458-63. [Full Text/Abstract]
Decker KB, Chen Q, Hsieh ML, Boucher P, Stibitz S, Hinton DM. Different requirements for σ Region 4 in BvgA activation of the Bordetella pertussis promoters P(fim3) and P(fhaB).J. Mol. Biol. 2011 Jun 24; 409 (2011 Jun 24; 409; 5) :692-709. [Full Text/Abstract]
Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW. O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.Genetics. 2011 Jun; 188 (188; 2; 2011 Jun) :369-82. [Full Text/Abstract]
Qin M, Entezam A, Usdin K, Huang T, Liu ZH, Hoffman GE, Smith CB. A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis.Neurobiol. Dis. 2011 Apr; 42 (2011 Apr; 42; 1) :85-98. [Full Text/Abstract]
Kumari D, Biacsi RE, Usdin K. Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells.J. Biol. Chem. 2011 Feb 11; 286 (6; 2011 Feb 11; 286) :4209-15. [Full Text/Abstract]
Hanover JA. A versatile sugar transferase makes the cut.Cell. 2011 Feb 4; 144 (144; 3; 2011 Feb 4) :321-3. [Full Text/Abstract]
Sundborger A, Soderblom C, Vorontsova O, Evergren E, Hinshaw JE, Shupliakov O. An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling.J. Cell. Sci. 2011 Jan 1; 124 (124; Pt 1; 2011 Jan 1) :133-43. [Full Text/Abstract]
Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission.Nat. Struct. Mol. Biol. 2011 Jan; 18 (2011 Jan; 1; 18) :20-6. [Full Text/Abstract]
Hanover JA. Epigenetics gets sweeter: O-GlcNAc joins the "histone code".Chem. Biol. 2010 Dec 22; 17 (17; 12; 2010 Dec 22) :1272-4. [Full Text/Abstract]
Webster MT, McCaffery JM, Cohen-Fix O. Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation.J. Cell Biol. 2010 Dec 13; 191 (6; 2010 Dec 13; 191) :1079-88. [Full Text/Abstract]