U.S. Department of Health and Human Services

Laboratory of Cell and Molecular Biology

John A. Hanover, Ph.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Adihe Lokanga R, Zhao XN, Entezam A, Usdin K. X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion. Hum Mol Genet. 2014 Sep 15; 23 (18):4985-94. [Full Text/Abstract]
Abd-Elmoniem KZ, Bakalov VK, Matta JR, Muldoon N, Hanover JA, Bondy CA, Gharib AM. X Chromosome Parental Origin and Aortic Stiffness in Turner Syndrome. Clin Endocrinol (Oxf). 2014 Sep; 81 (3):467-70. [Full Text/Abstract]
Chen Q, Boulanger A, Hinton DM, Stibitz S. Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in Bordetella pertussis. Mol Microbiol. 2014 Aug; 93 (4):748-58. [Full Text/Abstract]
Kumari D, Usdin K. Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription. Hum Mol Genet. 2014 Jul 23. [Full Text/Abstract]
Prinz WA. Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics. J Cell Biol. 2014 Jun 23; 205 (6):759-69. [Full Text/Abstract]
Stichelen SO, Abramowitz LK, Hanover JA. X Marks the Spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?. Biochem Biophys Res Commun. 2014 Jun 21. [Full Text/Abstract]
Kim EJ, Abramowitz LK, Bond MR, Love DC, Ahn JS, Kang DW, Leucke HF, Kang DW, Hanover JA. Versatile O-GlcNAc Transferase Assay for High-throughput Identification of Enzyme Variants, Substrates, and Inhibitors. Bioconjug Chem. 2014 Jun 18; 25 (6):1025-30. [Full Text/Abstract]
Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE. A dynamin mutant defines a super-constricted pre-fission state. Cell Reports, in press. June 12, 2014. [Full Text/Abstract]
Yudkin D, Hayward BE, Aladjem MI, Kumari D, Usdin K. Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome. Hum Mol Genet. 2014 Jun 1; 23 (11):2940-52. [Full Text/Abstract]
Palencia ER, Mitchell TR, Snook ME, Glenn AE, Gold S, Hinton DM, Riley RT, Bacon CW. Analyses of Black Aspergillus Species of Peanut and Maize for Ochratoxins and Fumonisins. J Food Prot. 2014 May; 77 (5):805-813. [Full Text/Abstract]
Harwood KR, Hanover JA. Nutrient-driven O-GlcNAc cycling - think globally but act locally. J Cell Sci. 2014 May 1; 127 (Pt 9):1857-67. [Full Text/Abstract]
Chen J, Miller BF, Furano AV. Repair of naturally occurring mismatches can induce mutations in flanking DNA. Elife. 2014 Apr 29; 3 :e02001. [Full Text/Abstract]
Zhao XN, Usdin K. Gender and Cell-Type Specific Effects of the Transcription Coupled Repair Protein, ERCC6/CSB, on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders. Hum Mutat. 2014 Mar; 35 (3):341-9. [Full Text/Abstract]
Rahman MM, Rosu S, Joseph-Strauss D, Cohen-Fix O. Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2014 Feb 18; 111 (7):2602-7. [Full Text/Abstract]
Heald R, Cohen-Fix O. Morphology and function of membrane-bound organelles. Curr Opin Cell Biol. 2014 Feb; 26 :79-86. [Full Text/Abstract]
Prinz WA. The lipid trade. Nat Rev Mol Cell Biol. 2014 Feb; 15 (2):79. [Full Text/Abstract]
Lokanga RA, Zhao XN, Usdin K. The mismatch repair protein MSH2 is rate limiting for repeat expansion in a fragile X premutation mouse model. Hum Mutat. 2014 Jan; 35 (1):129-36. [Full Text/Abstract]
Sarker MM, Zhou M, Rameshwar P, Hanover JA. Functions and Roles of Proteins: Diabetes as a Paradigm. Prog Biophys Mol Biol. 2014 Jan; 114 (1):2-7. [Full Text/Abstract]
Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum Mol Genet. 2013 Mar 15; 22 (6):1180-92. [Full Text/Abstract]
Lokanga RA, Entezam A, Kumari D, Yudkin D, Qin M, Smith CB, Usdin K. Somatic expansion in mouse and human carriers of fragile X premutation alleles. Hum Mutat. 2013 Jan; 34 (1):157-66. [Full Text/Abstract]
Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci. 2012 Oct 15; 125 (Pt 20):4791-9. [Full Text/Abstract]
Walters AD, Bommakanti A, Cohen-Fix O. Shaping the nucleus: factors and forces. J Cell Biochem. 2012 Sep; 113 (9):2813-21. [Full Text/Abstract]
Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem. 2012 Jul 6; 287 (28):23549-61. [Full Text/Abstract]
Decker KB, James TD, Stibitz S, Hinton DM. The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA. Microbiology. 2012 Jul; 158 (Pt 7):1665-76. [Full Text/Abstract]
Kumari D, Lokanga R, Yudkin D, Zhao XN, Usdin K. Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia. Biochim Biophys Acta. 2012 Jul; 1819 (7):802-10. [Full Text/Abstract]
Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, Cohen-Fix O. The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. Curr Biol. 2012 Jun 19; 22 (12):1128-33. [Full Text/Abstract]
Hoffman GE, Le WW, Entezam A, Otsuka N, Tong ZB, Nelson L, Flaws JA, McDonald JH, Jafar S, Usdin K. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. J Histochem Cytochem. 2012 Jun; 60 (6):439-56. [Full Text/Abstract]
Dolezal D, Jones CE, Lai X, Brister JR, Mueser TC, Nossal NG, Hinton DM. Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA. J Biol Chem. 2012 May 25; 287 (22):18596-607. [Full Text/Abstract]
Joseph-Strauss D, Gorjánácz M, Santarella-Mellwig R, Voronina E, Audhya A, Cohen-Fix O. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Dev Biol. 2012 May 15; 365 (2):445-57. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol. 2012 Apr 23; 13 (5):312-21. [Full Text/Abstract]