U.S. Department of Health and Human Services

Laboratory of Cell and Molecular Biology

John A. Hanover, Ph.D., Chief

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TitleDescriptionImage
The Hexosamine Signaling PathwayThis image depicts the Nutrient Sensing Hexosamine signaling pathway terminating in O-GlcNAc addition and removal. This pathway may be deregulated in human diseases such as diabetes.The Hexosamine Signaling PathwayEnlarge
Calmodulin-Dependent Nuclear ImportCalmodulin-Dependent Nuclear ImportEnlarge
OGT isoforms are differentially targeted to nucleus and mitochondria in Hela cellsUsing an antisera to OGT (green) and mitotracker (red), OGT isoforms were shown to be present in nucleus and mitochondria.OGT isoforms are differentially targeted to nucleus and mitochondria in Hela cellsEnlarge
Structure of the TPR domain of OGT has similarities to Importin alphaStructure of the TPR domain of OGT has similarities to Importin alphaEnlarge
O-GlcNAc cycling modulates insulin signaling and Dauer in C. elegansIn C. elegans, insulin-like signaling regulates longevity, stress response, and the entry into the diapause state termed dauer. Knockout of ogt-1 leads to reduced dauer formation (insulin hypersensitivity), while knockout of oga-1 results in enhanced dauer formation (insulin resistance).O-GlcNAc cycling modulates insulin signaling and Dauer in C. elegansEnlarge