U.S. Department of Health and Human Services
Labs & Branches

​About the Lab/Branch

Current research in the Laboratory of Chemical Physics is primarily concerned with experimental, theoretical, and computational problems in the structure, dynamics, and function of biological macromolecules.​

​Current Research

Scientists in the lab study diverse topics in chemical physics. These include:

  • fundamental aspects of the mechanism of protein folding;
  • new techniques and approaches for determining the structure and dynamics of bioactive molecules;
  • the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional NMR spectroscopy;
  • solid-state NMR methods for structural studies of biopolymers;
  • the gap between theory and experiment; and
  • the relationships between protein structure, dynamics, and function using ultrafast time-resolved laser spectroscopy and X-ray crystallography.

Experimental techniques include solution and solid-state nuclear magnetic resonance spectroscopy (NMR), time-resolved X-ray crystallography and optical spectroscopy, rapid kinetics methods, and single molecule spectroscopy. The development of fundamental aspects of experimental and theoretical techniques is an active area in the laboratory. ​