U.S. Department of Health and Human Services

Laboratory of Chemical Physics

William A. Eaton, M.D., Ph.D., Chief

​Research Images

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TitleDescriptionImage
Single molecule folding and unfolding trajectoryTrajectory of a single protein molecule folding and unfolding monitored by fluorescence resonance energy transfer from green-emitting donor dye to red-emitting acceptor dye.Enlarge
Electron microscope images of amyloid fibrilsElectron microscope images of amyloid fibrils formed by the 40-residue beta-amyloid peptide are depicted, with either "twisted" or "striated ribbon" morphologies (left). Corresponding molecular structural models, based on data from solid-state NMR and electron microscopy are shown (right).Enlarge
Custom-built apparatus for solid state NMR at low temperatures with dynamic nuclear polarization (DNP)A custom-built apparatus for solid-state NMR at low temperatures with dynamic nuclear polarization (DNP) is depicted (left). A carbon-13 NMR spectrum of an isotopically labeled peptide in frozen solution at 25 K, with and without signal enhancement from DNP is shown (right).Enlarge
Structural model for a pentameric assembly of transmembrane segments of the HIV-1 VpuproteinStructural model for a pentameric assembly of transmembrane segments of the HIV-1 Vpu protein, based on solid-state NMR and photochemical crosslinking data.Enlarge
NMR MagnetNuclear magnetic resonance magnet (9.4 Tesla = 400 MHz, wide bore).Enlarge