U.S. Department of Health and Human Services

Clinical Research Section

T. Jake Liang, M.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C.Gut. 2013 Feb 8 (2013 Feb 8) . [Full Text/Abstract]
Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.Nat Med. 2012 Jul; 18 (7; 2012 Jul; 18) :1060-8. [Full Text/Abstract]
Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ. HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons.Gastroenterology. 2012 Apr; 142 (4; 2012 Apr; 142) :978-88. [Full Text/Abstract]
Edlich B, Ahlenstiel G, Zabaleta Azpiroz A, Stoltzfus J, Noureddin M, Serti E, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients.Hepatology. 2012 Jan; 55 (55; 1; 2012 Jan) :39-48. [Full Text/Abstract]
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM, Alcohol Genome-wide Association (AlcGen) Consortium, Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Global Lipids Genetics Consortium, Genetics of Liver Disease (GOLD) Consortium, International Consortium for Blood Pressure (ICBP-GWAS), Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.Nat Genet. 2011 Oct 16; 43 (43; 11; 2011 Oct 16) :1131-8. [Full Text/Abstract]
Sandler NG, Koh C, Roque A, Eccleston JL, Siegel RB, Demino M, Kleiner DE, Deeks SG, Liang TJ, Heller T, Douek DC. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection.Gastroenterology. 2011 Oct; 141 (4; 141; 2011 Oct) :1220-30, 1230.e1-3. [Full Text/Abstract]
Barth H, Rybczynska J, Patient R, Choi Y, Sapp RK, Baumert TF, Krawczynski K, Liang TJ. Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees.Hepatology. 2011 Oct; 54 (4; 2011 Oct; 54) :1135-48. [Full Text/Abstract]
Ahlenstiel G, Edlich B, Hogdal LJ, Rotman Y, Noureddin M, Feld JJ, Holz LE, Titerence RH, Liang TJ, Rehermann B. Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C.Gastroenterology. 2011 Oct; 141 (4; 141; 2011 Oct) :1231-9, 1239.e1-2. [Full Text/Abstract]
Feld JJ, Modi AA, El-Diwany R, Rotman Y, Thomas E, Ahlenstiel G, Titerence R, Koh C, Cherepanov V, Heller T, Ghany MG, Park Y, Hoofnagle JH, Liang TJ. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders.Gastroenterology. 2011 Mar; 140 (2011 Mar; 140; 3) :830-9. [Full Text/Abstract]
Thomas E, Feld JJ, Li Q, Hu Z, Fried MW, Liang TJ. Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models.Hepatology. 2011 Jan; 53 (2011 Jan; 53; 1) :32-41. [Full Text/Abstract]
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, NASH CRN. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease.Hepatology. 2010 Sep; 52 (2010 Sep; 3; 52) :894-903. [Full Text/Abstract]
Zhang Z, Sun E, Ou JH, Liang TJ. Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo.J Virol. 2010 Sep; 84 (2010 Sep; 18; 84) :9326-31. [Full Text/Abstract]
Feld JJ, Lutchman GA, Heller T, Hara K, Pfeiffer JK, Leff RD, Meek C, Rivera M, Ko M, Koh C, Rotman Y, Ghany MG, Haynes-Williams V, Neumann AU, Liang TJ, Hoofnagle JH. Ribavirin improves early responses to peginterferon through improved interferon signaling.Gastroenterology. 2010 Jul; 139 (2010 Jul; 139; 1) :154-62.e4. [Full Text/Abstract]
de Mochel NS, Seronello S, Wang SH, Ito C, Zheng JX, Liang TJ, Lambeth JD, Choi J. Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection.Hepatology. 2010 Jul; 52 (2010 Jul; 52; 1) :47-59. [Full Text/Abstract]
He XS, Nanda S, Ji X, Calderon-Rodriguez GM, Greenberg HB, Liang TJ. Differential transcriptional responses to interferon-alpha and interferon-gamma in primary human hepatocytes.J Interferon Cytokine Res. 2010 May; 30 (30; 2010 May; 5) :311-20. [Full Text/Abstract]
Ahlenstiel G, Titerence RH, Koh C, Edlich B, Feld JJ, Rotman Y, Ghany MG, Hoofnagle JH, Liang TJ, Heller T, Rehermann B. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner.Gastroenterology. 2010 Jan; 138 (138; 2010 Jan; 1) :325-35.e1-2. [Full Text/Abstract]
Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ. A genome-wide genetic screen for host factors required for hepatitis C virus propagation.Proc Natl Acad Sci U S A. 2009 Sep 22; 106 (106; 2009 Sep 22; 38) :16410-5. [Full Text/Abstract]
Rotman Y, Liang TJ. Coinfection with hepatitis C virus and human immunodeficiency virus: virological, immunological, and clinical outcomes.J Virol. 2009 Aug; 83 (83; 2009 Aug; 15) :7366-74. [Full Text/Abstract]
Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ. Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry.Gastroenterology. 2009 Aug; 137 (2009 Aug; 2; 137) :673-81. [Full Text/Abstract]
Yee LJ, Im K, Borg B, Yang H, Liang TJ, Virahep-C Study. Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.Genes Immun. 2009 Jun; 10 (4; 10; 2009 Jun) :365-72. [Full Text/Abstract]
Rotman Y, Brown TA, Hoofnagle JH. Evaluation of the patient with hepatitis B.Hepatology. 2009 May; 49 (49; 5 Suppl; 2009 May) :S22-7. [Full Text/Abstract]
von Rosenvinge EC, Koh C, Rotman Y, Lim RM. Electronic clinical challenges and images in GI. Gastrointestinal malignant melanoma.Gastroenterology. 2008 Jul; 135 (2008 Jul; 135; 1) :e5-6. [Full Text/Abstract]
Schmilovitz-Weiss H, Niv Y, Pappo O, Halpern M, Sulkes J, Braun M, Barak N, Rotman Y, Cohen M, Waked A, Tur-Kaspa R, Ben-Ari Z. The 13C-caffeine breath test detects significant fibrosis in patients with nonalcoholic steatohepatitis.J Clin Gastroenterol. 2008 Apr; 42 (2008 Apr; 42; 4) :408-12. [Full Text/Abstract]
Cohen M, Bachmatov L, Ben-Ari Z, Rotman Y, Tur-Kaspa R, Zemel R. Development of specific antibodies to an ARF protein in treated patients with chronic HCV infection.Dig Dis Sci. 2007 Sep; 52 (9; 2007 Sep; 52) :2427-32. [Full Text/Abstract]
Elmowalid GA, Qiao M, Jeong SH, Borg BB, Baumert TF, Sapp RK, Hu Z, Murthy K, Liang TJ. Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees.Proc Natl Acad Sci U S A. 2007 May 15; 104 (20; 104; 2007 May 15) :8427-32. [Full Text/Abstract]
Huang Y, Feld JJ, Sapp RK, Nanda S, Lin JH, Blatt LM, Fried MW, Murthy K, Liang TJ. Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C.Gastroenterology. 2007 Feb; 132 (2; 132; 2007 Feb) :733-44. [Full Text/Abstract]