U.S. Department of Health and Human Services

Genetics and Metabolism Section

Caroline C. Philpott, M.D., Chief


A selection of recent and significant publications can be viewed below.

Frey AG, Nandal A, Park JH, Smith PM, Yabe T, Ryu MS, Ghosh MC, Lee J, Rouault TA, Park MH, Philpott CC. Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proc Natl Acad Sci U S A. 2014 Jun 3; 111 (22):8031-6. [Full Text/Abstract]
Leidgens S, Bullough KZ, Shi H, Li F, Shakoury-Elizeh M, Yabe T, Subramanian P, Hsu E, Natarajan N, Nandal A, Stemmler TL, Philpott CC. Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin. J Biol Chem. 2013 Jun 14; 288 (24):17791-802. [Full Text/Abstract]
Cyert MS, Philpott CC. Regulation of cation balance in Saccharomyces cerevisiae. Genetics. 2013 Mar; 193 (3):677-713. [Full Text/Abstract]
Philpott CC, Leidgens S, Frey AG. Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta. 2012 Sep; 1823 (9):1509-20. [Full Text/Abstract]
Philpott CC. Coming into view: eukaryotic iron chaperones and intracellular iron delivery. J Biol Chem. 2012 Apr 20; 287 (17):13518-23. [Full Text/Abstract]
Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab. 2011 Nov 2; 14 (5):647-57. [Full Text/Abstract]
Guo Y, Au WC, Shakoury-Elizeh M, Protchenko O, Basrai M, Prinz WA, Philpott CC. Phosphatidylserine is involved in the ferrichrome-induced plasma membrane trafficking of Arn1 in Saccharomyces cerevisiae. J Biol Chem. 2010 Dec 10; 285 (50):39564-73. [Full Text/Abstract]
Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott CC. Metabolic response to iron deficiency in Saccharomyces cerevisiae. J Biol Chem. 2010 May 7; 285 (19):14823-33. [Full Text/Abstract]
Deng Y, Guo Y, Watson H, Au WC, Shakoury-Elizeh M, Basrai MA, Bonifacino JS, Philpott CC. Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole. J Biol Chem. 2009 Aug 28; 284 (35):23830-41. [Full Text/Abstract]
Shi H, Bencze KZ, Stemmler TL, Philpott CC. A cytosolic iron chaperone that delivers iron to ferritin. Science. 2008 May 30; 320 (5880):1207-10. [Full Text/Abstract]
Protchenko O, Shakoury-Elizeh M, Keane P, Storey J, Androphy R, Philpott CC. Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae. Eukaryot Cell. 2008 May; 7 (5):859-71. [Full Text/Abstract]
Philpott CC, Protchenko O. Response to iron deprivation in Saccharomyces cerevisiae. Eukaryot Cell. 2008 Jan; 7 (1):20-7. [Full Text/Abstract]
Kim Y, Deng Y, Philpott CC. GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae. Mol Biol Cell. 2007 May; 18 (5):1790-802. [Full Text/Abstract]
Protchenko O, Rodriguez-Suarez R, Androphy R, Bussey H, Philpott CC. A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. J Biol Chem. 2006 Jul 28; 281 (30):21445-57. [Full Text/Abstract]
Philpott CC. Iron uptake in fungi: a system for every source. Biochim Biophys Acta. 2006 Jul; 1763 (7):636-45. [Full Text/Abstract]
Kim Y, Lampert SM, Philpott CC. A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1. EMBO J. 2005 Mar 9; 24 (5):952-62. [Full Text/Abstract]
Shakoury-Elizeh M, Tiedeman J, Rashford J, Ferea T, Demeter J, Garcia E, Rolfes R, Brown PO, Botstein D, Philpott CC. Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Mol Biol Cell. 2004 Mar; 15 (3):1233-43. [Full Text/Abstract]
Protchenko O, Philpott CC. Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem. 2003 Sep 19; 278 (38):36582-7. [Full Text/Abstract]
Pelletier B, Beaudoin J, Philpott CC, Labbé S. Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res. 2003 Aug 1; 31 (15):4332-44. [Full Text/Abstract]
Moore RE, Kim Y, Philpott CC. The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2003 May 13; 100 (10):5664-9. [Full Text/Abstract]
Kim Y, Yun CW, Philpott CC. Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome transporter, Arn1p, in Saccharomyces cerevisiae. EMBO J. 2002 Jul 15; 21 (14):3632-42. [Full Text/Abstract]