U.S. Department of Health and Human Services

Liver Diseases Branch

Tsanyang Liang, Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection. Hepatology. 2014 Feb 23; 60 (4; 2014 Feb 23; 60):1160-1169. [Full Text/Abstract]
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection. Hepatology. 2014 Feb 23; 60 (4; 2014 Feb 23; 60):1160-1169. [Full Text/Abstract]
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection. Hepatology. 2014 Feb 23; 60 (4; 2014 Feb 23; 60):1160-1169. [Full Text/Abstract]
Guay-Woodford LM, Bissler JJ, Braun MC, Bockenhauer D, Cadnapaphornchai MA, Dell KM, Kerecuk L, Liebau MC, Alonso-Peclet MH, Shneider B, Emre S, Heller T, Kamath BM, Murray KF, Moise K, Eichenwald EE, Evans J, Keller RL, Wilkins-Haug L, Bergmann C, Gunay-Aygun M, Hooper SR, Hardy KK, Hartung EA, Streisand R, Perrone R, Moxey-Mims M. Consensus expert recommendations for the diagnosis and management of autosomal recessive polycystic kidney disease: report of an international conference. J Pediatr. 2014 Sep; 165 (165; 3; 2014 Sep):611-7. [Full Text/Abstract]
Veerapu NS, Park SH, Tully DC, Allen TM, Rehermann B. Trace amounts of sporadically reappearing HCV RNA can cause infection. J Clin Invest. 2014 Aug 1; 124 (124; 8; 2014 Aug 1):3469-78. [Full Text/Abstract]
Rehermann B, Bertoletti A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology. 2014 Jul 21; (2014 Jul 21). [Full Text/Abstract]
Serti E, Werner JM, Chattergoon M, Cox AL, Lohmann V, Rehermann B. Monocytes Activate Natural Killer Cells via Inflammasome-induced Interleukin 18 in Response to Hepatitis C Virus Replication. Gastroenterology. 2014 Jul; 147 (147; 2014 Jul; 1):209-220.e3. [Full Text/Abstract]
Heller T, Rotman Y, Koh C, Clark S, Haynes-Williams V, Chang R, McBurney R, Schmid P, Albrecht J, Kleiner DE, Ghany MG, Liang TJ, Hoofnagle JH. Long-term therapy of chronic delta hepatitis with peginterferon alfa. Aliment Pharmacol Ther. 2014 Jul; 40 (40; 2014 Jul; 1):93-104. [Full Text/Abstract]
Heller T, Rotman Y, Koh C, Clark S, Haynes-Williams V, Chang R, McBurney R, Schmid P, Albrecht J, Kleiner DE, Ghany MG, Liang TJ, Hoofnagle JH. Long-term therapy of chronic delta hepatitis with peginterferon alfa. Aliment Pharmacol Ther. 2014 Jul; 40 (40; 2014 Jul; 1):93-104. [Full Text/Abstract]
Sakiani S, Koh C, Heller T. Understanding The Presence of False Positive Antibodies in Acute Hepatitis. J Infect Dis. 2014 Jun 18; 210 (2014 Jun 18; 210; 12):1886-9. [Full Text/Abstract]
Frey AG, Nandal A, Park JH, Smith PM, Yabe T, Ryu MS, Ghosh MC, Lee J, Rouault TA, Park MH, Philpott CC. Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proc Natl Acad Sci U S A. 2014 Jun 3; 111 (111; 22; 2014 Jun 3):8031-6. [Full Text/Abstract]
Liang TJ, Ghany MG. Therapy of Hepatitis C - Back to the Future. N Engl J Med. 2014 May 22; 370 (2014 May 22; 21; 370):2043-7. [Full Text/Abstract]
Li Q, Zhang YY, Chiu S, Hu Z, Lan KH, Cha H, Sodroski C, Zhang F, Hsu CS, Thomas E, Liang TJ. Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle. PLoS Pathog. 2014 May; 10 (2014 May; 10; 5):e1004163. [Full Text/Abstract]
Hu Z, Lan KH, He S, Swaroop M, Hu X, Southall N, Zheng W, Liang TJ. Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds. Antimicrob Agents Chemother. 58 (58; 5):2995. [Full Text/Abstract]
Kang W, Sung PS, Park SH, Yoon S, Chang DY, Kim S, Han KH, Kim JK, Rehermann B, Chwae YJ, Shin EC. Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8(+) t cell effector functions. Gastroenterology. 2014 May; 146 (146; 2014 May; 5):1351-1360.e4. [Full Text/Abstract]
Koh C, Liang TJ. What is the future of ribavirin therapy for hepatitis C?. Antiviral Res. 2014 Apr; 104 (104; 2014 Apr):34-9. [Full Text/Abstract]
Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014 Mar 14; 343 (6176; 343; 2014 Mar 14):1221-8. [Full Text/Abstract]
Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield MS, Boehm M, Kastner DL, Aksentijevich I. Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med. 2014 Mar 6; 370 (2014 Mar 6; 10; 370):911-20. [Full Text/Abstract]
Brownell J, Bruckner J, Wagoner J, Thomas E, Loo YM, Gale M Jr, Liang TJ, Polyak SJ. Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection. J Virol. 2014 Feb; 88 (2014 Feb; 3; 88):1582-90. [Full Text/Abstract]
Park SH, Rehermann B. Immune responses to HCV and other hepatitis viruses. Immunity. 2014 Jan 16; 40 (40; 2014 Jan 16; 1):13-24. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Demino M, Page S, Nagabhyru PR, Rehermann B, Liang TJ, Hoofnagle JH, Heller T. Sequence analysis of hepatitis C virus from patients with relapse after a sustained virological response: relapse or reinfection?. J Infect Dis. 2014 Jan 1; 209 (209; 2014 Jan 1; 1):38-45. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014 Jan; 63 (2014 Jan; 63; 1):161-9. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014 Jan; 63 (2014 Jan; 63; 1):161-9. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Demino M, Page S, Nagabhyru PR, Rehermann B, Liang TJ, Hoofnagle JH, Heller T. Sequence analysis of hepatitis C virus from patients with relapse after a sustained virological response: relapse or reinfection?. J Infect Dis. 2014 Jan 1; 209 (209; 2014 Jan 1; 1):38-45. [Full Text/Abstract]
Sugiyama N, Murayama A, Suzuki R, Watanabe N, Shiina M, Liang TJ, Wakita T, Kato T. Single strain isolation method for cell culture-adapted hepatitis C virus by end-point dilution and infection. PLoS One. 2014; 9 (2014; 9; 5):e98168. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014 Jan; 63 (2014 Jan; 63; 1):161-9. [Full Text/Abstract]
Liang TR, Shen F, Liang TJ, Yin W, Yu QZ, Yu CX. VALIDATION OF SOURCE BIASING METHOD FOR ITS USE IN CSNS BEAMLINE SHIELDING CALCULATION. Radiat Prot Dosimetry. 2013 Dec 26; (2013 Dec 26). [Full Text/Abstract]
Werner JM, Heller T, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Stevens M, Schmitt J, Rehermann B. Innate immune responses in hepatitis C virus exposed healthcare workers who do not develop acute infection. Hepatology. 2013 Nov; 58 (58; 2013 Nov; 5):1621-31. [Full Text/Abstract]
Koh C, Turner T, Zhao X, Minniti CP, Feld JJ, Simpson J, Demino M, Conrey AK, Jackson MJ, Seamon C, Kleiner DE, Kato GJ, Heller T. Liver stiffness increases acutely during sickle cell vaso-occlusive crisis. Am J Hematol. 2013 Nov; 88 (2013 Nov; 11; 88):E250-4. [Full Text/Abstract]
Heller T, Werner JM, Rahman F, Mizukoshi E, Sobao Y, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Herrine SK, Stevens M, Schmitt J, Rehermann B. Occupational Exposure to Hepatitis C Virus: Early T-Cell Responses in the Absence of Seroconversion in a Longitudinal Cohort Study. J Infect Dis. 2013 Sep; 208 (6; 2013 Sep; 208):1020-5. [Full Text/Abstract]
Alimchandani M, Lai JP, Aung PP, Khangura S, Kamal N, Gallin JI, Holland SM, Malech HL, Heller T, Miettinen M, Quezado MM. Gastrointestinal Histopathology in Chronic Granulomatous Disease: A Study of 87 Patients. Am J Surg Pathol. 2013 Sep; 37 (2013 Sep; 37; 9):1365-72. [Full Text/Abstract]
Safar Zadeh E, Lungu AO, Cochran EK, Brown RJ, Ghany MG, Heller T, Kleiner DE, Gorden P. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J Hepatol. 2013 Jul; 59 (59; 2013 Jul; 1):131-7. [Full Text/Abstract]
Leidgens S, Bullough KZ, Shi H, Li F, Shakoury-Elizeh M, Yabe T, Subramanian P, Hsu E, Natarajan N, Nandal A, Stemmler TL, Philpott CC. Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin. J Biol Chem. 2013 Jun 14; 288 (2013 Jun 14; 288; 24):17791-802. [Full Text/Abstract]
Hsu AP, Sowerwine KJ, Lawrence MG, Davis J, Henderson CJ, Zarember KA, Garofalo M, Gallin JI, Kuhns DB, Heller T, Milner JD, Puck JM, Freeman AF, Holland SM. Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism. J Allergy Clin Immunol. 2013 Jun; 131 (131; 6; 2013 Jun):1586-93. [Full Text/Abstract]
Alvarez-Downing MM, Kamal N, Inchauste SM, Khangura SK, Malech HL, Holland SM, Hughes MS, Heller T, Sherry RM. The role of surgery in the management of patients with refractory chronic granulomatous disease colitis. Dis Colon Rectum. 2013 May; 56 (56; 2013 May; 5):609-14. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Sakiani S, Hoofnagle JH, Heller T. Important factors in reliable determination of hepatitis C virus genotype by use of the 5' untranslated region. J Clin Microbiol. 2013 May; 51 (2013 May; 5; 51):1485-9. [Full Text/Abstract]
Fuss IJ, Friend J, Yang Z, He JP, Hooda L, Boyer J, Xi L, Raffeld M, Kleiner DE, Heller T, Strober W. Nodular regenerative hyperplasia in common variable immunodeficiency. J Clin Immunol. 2013 May; 33 (2013 May; 33; 4):748-58. [Full Text/Abstract]
Langan RC, Sherry RM, Avital I, Heller T, Henderson C, Holland SM, Freeman AF, Rudloff U. Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm?. J Gastrointest Surg. 2013 May; 17 (2013 May; 17; 5):1009-14. [Full Text/Abstract]
Kamal N, Chen C, Ling A, O'Donnell T, Heller T. Goodness gracious great balls of fire. BMJ Case Rep. 2013 Mar 15; 2013 (2013 Mar 15; 2013). [Full Text/Abstract]
Tana MM, Heller T. Autoantibodies in hepatitis C: red flag or bystander effect?. J Pediatr Gastroenterol Nutr. 2013 Mar; 56 (56; 2013 Mar; 3):243. [Full Text/Abstract]
Cyert MS, Philpott CC. Regulation of cation balance in Saccharomyces cerevisiae. Genetics. 2013 Mar; 193 (2013 Mar; 193; 3):677-713. [Full Text/Abstract]
Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet. 2013 Feb; 45 (2; 2013 Feb; 45):164-71. [Full Text/Abstract]
Oppenheimer AP, Koh C, McLaughlin M, Williamson JC, Norton TD, Laudadio J, Heller T, Kleiner DE, High KP, Morse CG. Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases. World J Gastroenterol. 2013 Jan 7; 19 (19; 2013 Jan 7; 1):115-21. [Full Text/Abstract]
Fricker Z, Levy E, Kleiner D, Taylor JG 6th, Koh C, Holland SM, Heller T. Case series: biliary leak after transjugular liver biopsy. Am J Gastroenterol. 2013 Jan; 108 (108; 1; 2013 Jan):145-7. [Full Text/Abstract]
Gunay-Aygun M, Font-Montgomery E, Lukose L, Tuchman Gerstein M, Piwnica-Worms K, Choyke P, Daryanani KT, Turkbey B, Fischer R, Bernardini I, Sincan M, Zhao X, Sandler NG, Roque A, Douek DC, Graf J, Huizing M, Bryant JC, Mohan P, Gahl WA, Heller T. Characteristics of congenital hepatic fibrosis in a large cohort of patients with autosomal recessive polycystic kidney disease. Gastroenterology. 2013 Jan; 144 (144; 1; 2013 Jan):112-121.e2. [Full Text/Abstract]
Eccleston JL, Koh C, Markello TC, Gahl WA, Heller T. An apparent homozygous deletion in maltase-glucoamylase, a lesson in the evolution of SNP arrays. Mol Genet Metab. 2012 Dec; 107 (2012 Dec; 107; 4):674-8. [Full Text/Abstract]
Park H, Serti E, Eke O, Muchmore B, Prokunina-Olsson L, Capone S, Folgori A, Rehermann B. IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection. Hepatology. 2012 Dec; 56 (2012 Dec; 56; 6):2060-70. [Full Text/Abstract]
Park SH, Shin EC, Capone S, Caggiari L, De Re V, Nicosia A, Folgori A, Rehermann B. Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus. Gastroenterology. 2012 Oct; 143 (2012 Oct; 4; 143):1048-60.e4. [Full Text/Abstract]
Philpott CC, Leidgens S, Frey AG. Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta. 2012 Sep; 1823 (1823; 2012 Sep; 9):1509-20. [Full Text/Abstract]
Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul; 18 (7; 2012 Jul; 18):1060-8. [Full Text/Abstract]