U.S. Department of Health and Human Services

Liver Diseases Branch

T. Jake Liang, M.D., Chief


A selection of recent and significant publications can be viewed below.

Alimchandani M, Lai JP, Aung PP, Khangura S, Kamal N, Gallin JI, Holland SM, Malech HL, Heller T, Miettinen M, Quezado MM. Gastrointestinal Histopathology in Chronic Granulomatous Disease: A Study of 87 Patients.Am J Surg Pathol. 2013 Jul 24 (2013 Jul 24) . [Full Text/Abstract]
Koh C, Turner T, Zhao X, Minniti CP, Feld JJ, Simpson J, Demino M, Conrey AK, Jackson MJ, Seamon C, Kleiner DE, Kato GJ, Heller T. Liver stiffness increases acutely during sickle cell vaso-occlusive crisis.Am J Hematol. 2013 Jul 5 (2013 Jul 5) . [Full Text/Abstract]
Safar Zadeh E, Lungu AO, Cochran EK, Brown RJ, Ghany MG, Heller T, Kleiner DE, Gorden P. The liver diseases of lipodystrophy: the long-term effect of leptin treatment.J Hepatol. 2013 Jul; 59 (59; 2013 Jul; 1) :131-7. [Full Text/Abstract]
Heller T, Werner JM, Rahman F, Mizukoshi E, Sobao Y, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Herrine SK, Stevens M, Schmitt J, Rehermann B. Occupational Exposure to Hepatitis C Virus: Early T-Cell Responses in the Absence of Seroconversion in a Longitudinal Cohort Study.J Infect Dis. 2013 Jun 28 (2013 Jun 28) . [Full Text/Abstract]
Hsu AP, Sowerwine KJ, Lawrence MG, Davis J, Henderson CJ, Zarember KA, Garofalo M, Gallin JI, Kuhns DB, Heller T, Milner JD, Puck JM, Freeman AF, Holland SM. Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism.J Allergy Clin Immunol. 2013 Jun; 131 (131; 6; 2013 Jun) :1586-93. [Full Text/Abstract]
Alvarez-Downing MM, Kamal N, Inchauste SM, Khangura SK, Malech HL, Holland SM, Hughes MS, Heller T, Sherry RM. The role of surgery in the management of patients with refractory chronic granulomatous disease colitis.Dis Colon Rectum. 2013 May; 56 (56; 2013 May; 5) :609-14. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Sakiani S, Hoofnagle JH, Heller T. Important factors in reliable determination of hepatitis C virus genotype by use of the 5' untranslated region.J Clin Microbiol. 2013 May; 51 (2013 May; 5; 51) :1485-9. [Full Text/Abstract]
Fuss IJ, Friend J, Yang Z, He JP, Hooda L, Boyer J, Xi L, Raffeld M, Kleiner DE, Heller T, Strober W. Nodular regenerative hyperplasia in common variable immunodeficiency.J Clin Immunol. 2013 May; 33 (2013 May; 33; 4) :748-58. [Full Text/Abstract]
Langan RC, Sherry RM, Avital I, Heller T, Henderson C, Holland SM, Freeman AF, Rudloff U. Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm?J Gastrointest Surg. 2013 May; 17 (2013 May; 17; 5) :1009-14. [Full Text/Abstract]
Kamal N, Chen C, Ling A, O'Donnell T, Heller T. Goodness gracious great balls of fire.BMJ Case Rep. 2013 Mar 15; 2013 (2013 Mar 15; 2013) . [Full Text/Abstract]
Werner JM, Heller T, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Stevens M, Schmitt J, Rehermann B. Innate immune responses in hepatitis C virus exposed healthcare workers who do not develop acute infection.Hepatology. 2013 Mar 5 (2013 Mar 5) . [Full Text/Abstract]
Tana MM, Heller T. Autoantibodies in hepatitis C: red flag or bystander effect?J Pediatr Gastroenterol Nutr. 2013 Mar; 56 (56; 2013 Mar; 3) :243. [Full Text/Abstract]
Cyert MS, Philpott CC. Regulation of cation balance in Saccharomyces cerevisiae.Genetics. 2013 Mar; 193 (2013 Mar; 193; 3) :677-713. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C.Gut. 2013 Feb 8 (2013 Feb 8) . [Full Text/Abstract]
Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.Nat Genet. 2013 Feb; 45 (2; 2013 Feb; 45) :164-71. [Full Text/Abstract]
Oppenheimer AP, Koh C, McLaughlin M, Williamson JC, Norton TD, Laudadio J, Heller T, Kleiner DE, High KP, Morse CG. Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases.World J Gastroenterol. 2013 Jan 7; 19 (19; 2013 Jan 7; 1) :115-21. [Full Text/Abstract]
Fricker Z, Levy E, Kleiner D, Taylor JG 6th, Koh C, Holland SM, Heller T. Case series: biliary leak after transjugular liver biopsy.Am J Gastroenterol. 2013 Jan; 108 (108; 1; 2013 Jan) :145-7. [Full Text/Abstract]
Gunay-Aygun M, Font-Montgomery E, Lukose L, Tuchman Gerstein M, Piwnica-Worms K, Choyke P, Daryanani KT, Turkbey B, Fischer R, Bernardini I, Sincan M, Zhao X, Sandler NG, Roque A, Douek DC, Graf J, Huizing M, Bryant JC, Mohan P, Gahl WA, Heller T. Characteristics of congenital hepatic fibrosis in a large cohort of patients with autosomal recessive polycystic kidney disease.Gastroenterology. 2013 Jan; 144 (144; 1; 2013 Jan) :112-121.e2. [Full Text/Abstract]
Eccleston JL, Koh C, Markello TC, Gahl WA, Heller T. An apparent homozygous deletion in maltase-glucoamylase, a lesson in the evolution of SNP arrays.Mol Genet Metab. 2012 Dec; 107 (2012 Dec; 107; 4) :674-8. [Full Text/Abstract]
Park H, Serti E, Eke O, Muchmore B, Prokunina-Olsson L, Capone S, Folgori A, Rehermann B. IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection.Hepatology. 2012 Dec; 56 (2012 Dec; 56; 6) :2060-70. [Full Text/Abstract]
Park SH, Shin EC, Capone S, Caggiari L, De Re V, Nicosia A, Folgori A, Rehermann B. Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus.Gastroenterology. 2012 Oct; 143 (2012 Oct; 4; 143) :1048-60.e4. [Full Text/Abstract]
Philpott CC, Leidgens S, Frey AG. Metabolic remodeling in iron-deficient fungi.Biochim Biophys Acta. 2012 Sep; 1823 (1823; 2012 Sep; 9) :1509-20. [Full Text/Abstract]
Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.Nat Med. 2012 Jul; 18 (7; 2012 Jul; 18) :1060-8. [Full Text/Abstract]
Fan X, Upadhyaya B, Wu L, Koh C, Santín-Durán M, Pittaluga S, Uzel G, Kleiner D, Williams E, Ma CA, Bodansky A, Oliveira JB, Edmonds P, Hornung R, Wong DW, Fayer R, Fleisher T, Heller T, Prussin C, Jain A. CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome.Clin Immunol. 2012 May; 143 (2012 May; 2; 143) :152-61. [Full Text/Abstract]
Philpott CC. Coming into view: eukaryotic iron chaperones and intracellular iron delivery.J Biol Chem. 2012 Apr 20; 287 (2012 Apr 20; 17; 287) :13518-23. [Full Text/Abstract]
Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ. HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons.Gastroenterology. 2012 Apr; 142 (4; 2012 Apr; 142) :978-88. [Full Text/Abstract]
Raghuraman S, Park H, Osburn WO, Winkelstein E, Edlin BR, Rehermann B. Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion.J Infect Dis. 2012 Mar 1; 205 (205; 2012 Mar 1; 5) :763-71. [Full Text/Abstract]
Leiding JW, Freeman AF, Marciano BE, Anderson VL, Uzel G, Malech HL, DeRavin S, Wilks D, Venkatesan AM, Zerbe CS, Heller T, Holland SM. Corticosteroid therapy for liver abscess in chronic granulomatous disease.Clin Infect Dis. 2012 Mar 1; 54 (2012 Mar 1; 5; 54) :694-700. [Full Text/Abstract]