U.S. Department of Health and Human Services

Translational Hepatology Unit

Theo Heller, Chief

Section Staff


Alyson Bradshaw, B.S., Postbac IRTA student
Alyson Bradshaw, B.S., Postbac IRTA student

Alyson Bradshaw attended the University of Florida where she received her BS in Biochemistry. While at the University of Florida, she participated in studies related to insects, agriculture, and chemical ecology. She then joined the Translational Hepatology Unit, LDB, NIDDK as a postbac IRTA in 2012. She is currently looking at the relationship between the microbiome and the progression of liver disease.

Jason Eccleston, B.S., Medical Scholars Research Program Fellow
Jason Eccleston, B.S., Medical Scholars Research Program Fellow

Jason Eccleston earned a B.S. from the University of Maryland College Park. He then joined the Liver Diseases Branch, NIDDK as a IRTA post-bacc research fellow focusing on the immunohistochemical analysis of liver diseases including nodular regenerative hyperplasia. This led to his interest in becoming a physician scientist and the University of Maryland School of Medicine in Baltimore where he currently pursues his Medical degree. Also, Jason joined the Translational Hepatology Unit, LDB, NIDDK in 2013 as a Medical Research Scholars Program fellow and is currently investigating microbial translocation in liver diseases.

Publications

  • Eccleston JL, Koh C, Markello TC, Gahl WA, Heller T. An apparent homozygous deletion in maltase-glucoamylase, a lesson in the evolution of SNP arrays. Molecular genetics and metabolism. 2012 Dec; 107(4): 674-8.
  • Sandler NG, Koh C, Roque A, Eccleston JL, Siegel RB, Demino M, Kleiner DE, Deeks SG, Liang TJ, Heller T, Douek DC. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology. 2011Oct; 141(4): 1220-30, 30 e1-3.

Mi Sun Moon, Ph.D., Post-Doctoral Fellow

 

Mi Sun Moon, Ph.D., Post-Doctoral Fellow

Mi Sun Moon received her Ph.D. in Microbiology and Immunology from Pennsylvania State College of Medicine, during which time she studied the effect of hepatic iron on acute and chronic liver disease using both in vitro and in vivo models. She then joined the Translational Hepatology Unit, LDB, NIDDK as a post-doctoral fellow in 2012 and currently works on a project investigating microbial translocation in liver disease.

Publications

  • Kim, D., Kim, Y. K., Moon, M. S., Lee, J. H., Im, J. O., Cho, Y. K., Hong, H. N. (2000) Coxsackievirus B4-induced neurotoxic effect in primary cultured rat neurons: Serotype specificity of enteroviral infections. Experimental Neurobiology 9, 1-6.
  • Moon, M. S., Lee, C. J., Um, S. J., Park, J. S., Yang, J. M., and Hwang, E. S. (2001) Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells, Gynecol Oncol 80, 168-175. PMID: 11161855
  • Park, Y. C., Nam, J. H., Joo, C. H., Moon, M. S., Chung, K. W., Lee, H., Cho, Y. K., Kim, Y. K. (2001) Sequence variation of 5' noncoding region of enterovirus isolated from patients with aseptic meningitis.J Bacteriol Virol 31, 85-94.
  • Joo, C. H., Yoon, H. J., Nam, J. H., Moon, M. S., Cho, Y. K., Woo, J. H., Kang, J. M., Shin, W. S., Kim, T. R., Kim, M. J., Chung, H. J., Lee, H. J., Kim, Y. K. (2001) A prospective multicenter study on the etiological analysis of community-acquired pneumonia in adult patients in Korea: detection of Mycoplasma pneumoniae and Chlamydia pneumoniae infections. Kor J Inf Dis 33, 15-24.
  • Joo, C. H., Hong, H. N., Kim, E. O., Im, J. O., Yoon, S. Y., Ye, J. S., Moon, M. S., Kim, D., Lee, H., and Kim, Y. K. (2003) Coxsackievirus B3 induces apoptosis in the early phase of murine myocarditis: a comparative analysis of cardiovirulent and noncardiovirulent strains, Intervirology 46, 135-140. PMID: 12867750
  • Kwon, T. W., Kim, D. K., Ye, J. S., Lee, W. J., Moon, M. S., Joo, C. H., Lee, H., and Kim, Y. K. (2004) Detection of enterovirus, cytomegalovirus, and Chlamydia pneumoniae in atheromas, J Microbiol 42, 299-304. PMID: 15650686
  • Lee, Y. J., Moon, M. S., Kwon, S. J., and Rhee, J. G. (2005) Hypoxia and low glucose differentially augments TRAIL-induced apoptotic death, Mol Cell Biochem 270, 89-97. PMID: 15792357
  • Moon, M. S., Joo, C. H., Hwang, I. S., Ye, J. S., Jun, E. J., Lee, H. S., Kim, D., Lee, M. J., Lee, H., and Kim, Y. K. (2005) Distribution of viral RNA in mouse tissues during acute phase of coxsackievirus B5 infection, Intervirology 48, 153-160. PMID: 15812189
  • Isom, H. C., McDevitt, E. I., and Moon, M. S. (2009) Elevated hepatic iron: a confounding factor in chronic hepatitis C, Biochim Biophys Acta 1790, 650-662. PMID: 19393721
  • Moon, M. S., Richie, J. P., and Isom, H. C. (2010) Iron potentiates Acetaminphen-Induced Oxidative Stress and Mitochondrial Dysfunction in Cultured Mouse Hepatocytes, Toxicol Sci 118 (1), 119-127. PMID: 20667997
  • Moon, M. S., Kang, B. H., Krzeminski, J., Amin, S., Aliaga, C., Zhu, J., McDevitt, E. I., Kocher, S., Richie, J. P., and Isom, H. C. (2011) 3,5,5-Trimethyl-Hexanoyl-Ferrocene Diet Protects Mice from Moderate Transient Acetaminophen-Induced Hepatotoxicity. Toxicol Sci 124 (2), 348-358. PMID: 21908766
  • Moon, M. S., McDevitt, E. I., Zhu, J., Stanley, B., Krzeminski, J., Amin, S., Aliaga, C., Miller, T., and Isom, H. C. (2012) Elevated Hepatic Iron Activates NF-E2–Related Factor 2–Regulated Pathway in a Dietary Iron Overload Mouse Model. Toxicol Sci 129 (1), 74-85. PMID: 22649188

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Sandy Page, Ph.D., Post-Doctoral Fellow

Sandy Page earned a B.A. from the University of Delaware and a Masters in Biology from George Mason University. She worked professionally as a biologist for the federal government; however, an interest in biomarker research led to her to North Carolina State University, where she earned a second Masters degree focusing on functional genomics and biomarker development. She subsequently worked for a breast cancer researcher and gained experience in applying molecular techniques to human health studies. In 2011 she completed a Ph.D. in Biosciences, with a concentration in Functional Genomics, from George Mason University. Her doctoral research involved the identification and validation of biomarkers of non-alcoholic fatty liver disease. She joined the Translational Hepatology Unit, LDB, NIDDK, in 2012 as a post-doctoral fellow. She is currently investigating whether genetic polymorphisms influence disease progression in patients with hepatitis C.

Publications

  • Page S, Birerdinc A, Estep M, Stepanova M, Afendy A, Petricoin E, Younossi Z, Chandhoke V, Baranova A. Knowledge-Based Identification of Soluble Biomarkers: Hepatic Fibrosis in NAFLD as an Example. PloS One. Accepted.
  • Page S. Novel Biomarkers for Non-Alcoholic Fatty Liver Disease and Associated Symptoms. George Mason University. 2011
  • Gerber L, Page S, Price J, Baranova A, Winter P, Younossi Z. Association of Serum Biomarkers with Fatigue in Patients with Chronic Liver Disease. Gastroenterology. 2011. May; 140(5):S-461.
  • Younossi ZM, Page S, Rafiq N, Birerdinc A, Stepanova M, Hossain N, Afendy A, Younoszai Z, Goodman Z, Baranova A. A biomarker panel for non-alcoholic steatohepatitis (NASH) and NASH-related fibrosis. Obes Surg. 2011 Apr;21(4):431-9.
  • Page S, Chandhoke V, Baranova A. Melanin and melanogenesis in adipose tissue: possible mechanisms for abating oxidative stress and inflammation? Obes Rev. 2011 May;12(5):e21-31. Review.
  • Younossi ZM, Baranova A, Stepanova M, Page S, Calvert VS, Afendy A, Goodman Z, Chandhoke V, Liotta L, Petricoin E. Phosphoproteomic biomarkers predicting histologic nonalcoholic steatohepatitis and fibrosis. J Proteome Res. 2010 Jun 4;9(6):3218-24.
  • Biderman B, Marakhonov A, Skoblov M, Birerdinc A, Nohelty E, Page S, Khomenkov V, Chandhoke V, Sudarikov A, Nikitin E, Baranova A. Inhibition of potassium currents as a pharmacologic target for investigation in chronic lymphocytic leukemia. Drug News Perspect. 2010 Dec;23(10):625-31. Review.
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