U.S. Department of Health and Human Services

Laboratory of Endocrinology and Receptor Biology

Marvin C. Gershengorn, M.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014 Nov 5; 5 (2014 Nov 5; 5):5425. [Full Text/Abstract]
Fu Y, Liu H, Ng L, Kim JW, Hao H, Swaroop A, Forrest D. Feedback Induction of a Photoreceptor-specific Isoform of Retinoid-related Orphan Nuclear Receptor β by the Rod Transcription Factor NRL. J Biol Chem. 2014 Oct 7; 289 (289; 2014 Oct 7; 47):32469-80. [Full Text/Abstract]
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 2014 Jul 27; 514 (514; 7520; 2014 Jul 27):107-111. [Full Text/Abstract]
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY. Gcn5 and PCAF Regulate PPARγ and Prdm16 Expression To Facilitate Brown Adipogenesis. Mol Cell Biol. 2014 Jul 28; 34 (19; 2014 Jul 28; 34):3746-53. [Full Text/Abstract]
Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K. Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1. EMBO Rep. 2014 Sep 30; 15 (2014 Sep 30; 15; 11):1192-201. [Full Text/Abstract]
Boutin A, Eliseeva E, Gershengorn MC, Neumann S. β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. FASEB J. 2014 Aug; 28 (28; 8; 2014 Aug):3446-55. [Full Text/Abstract]
Katz LS, Geras-Raaka E, Gershengorn MC. Heritability of fat accumulation in white adipocytes. Am J Physiol Endocrinol Metab. 2014 Aug 1; 307 (307; 2014 Aug 1; 3):E335-44. [Full Text/Abstract]
Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul; 243 (243; 7; 2014 Jul):937-47. [Full Text/Abstract]
Hiram-Bab S, Katz LS, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol. 2014 Jun; 229 (229; 6; 2014 Jun):743-51. [Full Text/Abstract]
Krieger CC, Gershengorn MC. A modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cells. Endocrinology. 2014 Feb; 155 (155; 2; 2014 Feb):627-34. [Full Text/Abstract]
Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan; 155 (155; 2014 Jan; 1):310-4. [Full Text/Abstract]
Lee JE, Ge K. Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis. Cell Biosci. 2014; 4 (2014; 4):29. [Full Text/Abstract]
Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013 Dec 24; 2 (0; 2; 2013 Dec 24):e01503. [Full Text/Abstract]
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 6; 153 (153; 6; 2013 Jun 6):1266-80. [Full Text/Abstract]
Ng L, Kelley MW, Forrest D. Making sense with thyroid hormone--the role of T(3) in auditory development. Nat Rev Endocrinol. 2013 May; 9 (2013 May; 9; 5):296-307. [Full Text/Abstract]
Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K. H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2013 Feb 7; 12 (2013 Feb 7; 2; 12):180-92. [Full Text/Abstract]
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis. EMBO J. 2013 Jan 9; 32 (32; 2013 Jan 9; 1):45-59. [Full Text/Abstract]
Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D. Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1. Endocrinology. 2013 Jan; 154 (1; 2013 Jan; 154):550-61. [Full Text/Abstract]
Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D. An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013; 4 (4; 2013):1813. [Full Text/Abstract]
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18; 109 (38; 109; 2012 Sep 18):15324-9. [Full Text/Abstract]
Boutin A, Allen MD, Neumann S, Gershengorn MC. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB J. 2012 Aug; 26 (2012 Aug; 8; 26):3473-82. [Full Text/Abstract]
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. Thyroid. 2012 Aug; 22 (2012 Aug; 8; 22):839-43. [Full Text/Abstract]
Ge K. Epigenetic regulation of adipogenesis by histone methylation. Biochim Biophys Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819):727-32. [Full Text/Abstract]
Forrest D, Swaroop A. Minireview: the role of nuclear receptors in photoreceptor differentiation and disease. Mol Endocrinol. 2012 Jun; 26 (2012 Jun; 6; 26):905-15. [Full Text/Abstract]
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D. Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones. Endocrinology. 2012 Mar; 153 (153; 2012 Mar; 3):1548-60. [Full Text/Abstract]
Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res. 2012 Jan 1; 72 (72; 1; 2012 Jan 1):315-24. [Full Text/Abstract]
Cho YW, Hong S, Ge K. Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex. Methods Mol Biol. 2012; 809 (2012; 809):465-72. [Full Text/Abstract]
Sharlin DS, Visser TJ, Forrest D. Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. Endocrinology. 2011 Dec; 152 (152; 12; 2011 Dec):5053-64. [Full Text/Abstract]
Alberobello AT, Congedo V, Liu H, Cochran C, Skarulis MC, Forrest D, Celi FS. An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone. J Transl Med. 2011 Aug 26; 9 (2011 Aug 26; 9):144. [Full Text/Abstract]
Ng L, Lu A, Swaroop A, Sharlin DS, Swaroop A, Forrest D. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. J Neurosci. 2011 Aug 3; 31 (2011 Aug 3; 31):11118-25. [Full Text/Abstract]
Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence. Thyroid. 2011 Aug; 21 (8; 21; 2011 Aug):907-12. [Full Text/Abstract]
Boutin A, Allen MD, Geras-Raaka E, Huang W, Neumann S, Gershengorn MC. Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. Mol Pharmacol. 2011 Aug; 80 (2; 80; 2011 Aug):240-6. [Full Text/Abstract]
Monga V, Meena CL, Rajput S, Pawar C, Sharma SS, Lu X, Gershengorn MC, Jain R. Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues. ChemMedChem. 2011 Mar 7; 6 (6; 2011 Mar 7; 3):531-43. [Full Text/Abstract]
Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb; 96 (2; 2011 Feb; 96):548-54. [Full Text/Abstract]
Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011 Jan 19; 30 (30; 2; 2011 Jan 19):249-62. [Full Text/Abstract]
Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G. Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. Cell Mol Life Sci. 2011 Jan; 68 (68; 2011 Jan; 1):159-67. [Full Text/Abstract]
Neumann S, Geras-Raaka E, Marcus-Samuels B, Gershengorn MC. Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization. FASEB J. 2010 Oct; 24 (2010 Oct; 10; 24):3992-9. [Full Text/Abstract]
Swaroop A, Kim D, Forrest D. Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina. Nat Rev Neurosci. 2010 Aug; 11 (8; 2010 Aug; 11):563-76. [Full Text/Abstract]
Neumann S, Huang W, Eliseeva E, Titus S, Thomas CJ, Gershengorn MC. A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Endocrinology. 2010 Jul; 151 (7; 2010 Jul; 151):3454-9. [Full Text/Abstract]
Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G. Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. FASEB J. 2010 Jul; 24 (7; 2010 Jul; 24):2347-54. [Full Text/Abstract]
Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, Hong S, Blais A, Brand M, Ge K, Dilworth FJ. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J. 2010 Apr 21; 29 (8; 29; 2010 Apr 21):1401-11. [Full Text/Abstract]
Wang L, Jin Q, Lee JE, Su IH, Ge K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107 (2010 Apr 20; 107; 16):7317-22. [Full Text/Abstract]
Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN Jr, Forrest D. Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci. 2010 Mar 3; 30 (2010 Mar 3; 30; 9):3347-57. [Full Text/Abstract]
Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009 Oct 13; 106 (106; 2009 Oct 13; 41):17534-9. [Full Text/Abstract]
Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28; 106 (106; 2009 Jul 28; 30):12471-6. [Full Text/Abstract]
Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab. 2009 Jul; 10 (2009 Jul; 10; 1):27-39. [Full Text/Abstract]
Sun Y, Zupan B, Raaka BM, Toth M, Gershengorn MC. TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes. Neuropsychopharmacology. 2009 May; 34 (6; 34; 2009 May):1601-8. [Full Text/Abstract]
Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, Forrest D. A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function. Endocrinology. 2009 Apr; 150 (2009 Apr; 150; 4):1952-60. [Full Text/Abstract]
Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem. 2009 Mar 13; 284 (284; 2009 Mar 13; 11):7284-93. [Full Text/Abstract]
Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol. 2008 Feb; 28 (28; 3; 2008 Feb):1081-91. [Full Text/Abstract]