U.S. Department of Health and Human Services

Laboratory of Endocrinology and Receptor Biology

Marvin C. Gershengorn, M.D., Chief


A selection of recent and significant publications can be viewed below.

Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L, Chu A, Palii CG, Liu C, Camellato B, Brand M, Ge K, Dilworth FJ. UTX demethylase activity is required for satellite cell-mediated muscle regeneration. J Clin Invest. 2016 Mar 21; 126 (126; 4; 2016 Mar 21):1555-1565. [Full Text/Abstract]
Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, Pflumio F, Hébert J, Couture JF, Perkins TJ, Ge K, Dilworth FJ, Brand M. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. Genes Dev. 2016 Mar 1; 30 (30; 5; 2016 Mar 1):508-21. [Full Text/Abstract]
Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG. KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1; 143 (5; 143; 2016 Mar 1):810-21. [Full Text/Abstract]
Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, Yuan J, Ge K, Montoya G, Nussenzweig A, Choudhary C, Daniel JA. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev. 2016 Jan 7; 30 (2016 Jan 7; 30; 2):149-163. [Full Text/Abstract]
Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L. Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nat Med. 2015 Sep 14; 21 (2015 Sep 14; 21; 10):1190-8. [Full Text/Abstract]
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nat Med. 2015 Sep 14; 21 (2015 Sep 14; 21; 10):1199-208. [Full Text/Abstract]
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014 Nov 5; 5 (2014 Nov 5; 5):5425. [Full Text/Abstract]
Fu Y, Liu H, Ng L, Kim JW, Hao H, Swaroop A, Forrest D. Feedback Induction of a Photoreceptor-specific Isoform of Retinoid-related Orphan Nuclear Receptor β by the Rod Transcription Factor NRL. J Biol Chem. 2014 Oct 7; 289 (289; 2014 Oct 7; 47):32469-80. [Full Text/Abstract]
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 2014 Jul 27; 514 (514; 7520; 2014 Jul 27):107-111. [Full Text/Abstract]
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY. Gcn5 and PCAF Regulate PPARγ and Prdm16 Expression To Facilitate Brown Adipogenesis. Mol Cell Biol. 2014 Jul 28; 34 (19; 2014 Jul 28; 34):3746-53. [Full Text/Abstract]
Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K. Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1. EMBO Rep. 2014 Sep 30; 15 (2014 Sep 30; 15; 11):1192-201. [Full Text/Abstract]
Katz LS, Geras-Raaka E, Gershengorn MC. Heritability of fat accumulation in white adipocytes. Am J Physiol Endocrinol Metab. 2014 Aug 1; 307 (307; 2014 Aug 1; 3):E335-44. [Full Text/Abstract]
Boutin A, Eliseeva E, Gershengorn MC, Neumann S. β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. FASEB J. 2014 Aug; 28 (28; 8; 2014 Aug):3446-55. [Full Text/Abstract]
Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr. Research Resource: Modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Mol Endocrinol. 2014 Jul; 28 (28; 7; 2014 Jul):me20141069. [Full Text/Abstract]
Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul; 243 (243; 7; 2014 Jul):937-47. [Full Text/Abstract]
Hiram-Bab S, Katz LS, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol. 2014 Jun; 229 (229; 6; 2014 Jun):743-51. [Full Text/Abstract]
Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr. A kinase-independent activity of cdk9 modulates glucocorticoid receptor-mediated gene induction. Biochemistry. 2014 Mar 25; 53 (2014 Mar 25; 53; 11):1753-67. [Full Text/Abstract]
Krieger CC, Gershengorn MC. A modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cells. Endocrinology. 2014 Feb; 155 (155; 2; 2014 Feb):627-34. [Full Text/Abstract]
Simons SS Jr, Edwards DP, Kumar R. Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges. Mol Endocrinol. 2014 Feb; 28 (28; 2; 2014 Feb):173-82. [Full Text/Abstract]
Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan; 155 (155; 2014 Jan; 1):310-4. [Full Text/Abstract]
Xu S, Grullon S, Ge K, Peng W. Spatial Clustering for Identification of ChIP-Enriched Regions (SICER) to Map Regions of Histone Methylation Patterns in Embryonic Stem Cells. Methods Mol Biol. 2014; 1150 (1150; 2014):97-111. [Full Text/Abstract]
Lee JE, Ge K. Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis. Cell Biosci. 2014; 4 (2014; 4):29. [Full Text/Abstract]
Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013 Dec 24; 2 (0; 2; 2013 Dec 24):e01503. [Full Text/Abstract]
Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons SS Jr. A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties. J Biol Chem. 2013 Nov 22; 288 (288; 2013 Nov 22; 47):34055-72. [Full Text/Abstract]
Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB. A Multifunctional Protein, EWS, Is Essential for Early Brown Fat Lineage Determination. Dev Cell. 2013 Aug 26; 26 (4; 2013 Aug 26; 26):393-404. [Full Text/Abstract]
Simons SS Jr, Kumar R. Variable steroid receptor responses: Intrinsically disordered AF1 is the key. Mol Cell Endocrinol. 2013 Aug 25; 376 (376; 2013 Aug 25; 1-2):81-4. [Full Text/Abstract]
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 6; 153 (153; 6; 2013 Jun 6):1266-80. [Full Text/Abstract]
Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA Jr, Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. J Biol Chem. 2013 May 24; 288 (2013 May 24; 288; 21):15167-80. [Full Text/Abstract]
Ng L, Kelley MW, Forrest D. Making sense with thyroid hormone--the role of T(3) in auditory development. Nat Rev Endocrinol. 2013 May; 9 (2013 May; 9; 5):296-307. [Full Text/Abstract]
Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V. The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. EMBO J. 2013 Apr 17; 32 (2013 Apr 17; 32; 8):1075-86. [Full Text/Abstract]
Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K. H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2013 Feb 7; 12 (2013 Feb 7; 2; 12):180-92. [Full Text/Abstract]
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis. EMBO J. 2013 Jan 9; 32 (32; 2013 Jan 9; 1):45-59. [Full Text/Abstract]
Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. J Biol Chem. 2013 Jan 4; 288 (2013 Jan 4; 288; 1):42-58. [Full Text/Abstract]
Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D. Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1. Endocrinology. 2013 Jan; 154 (1; 2013 Jan; 154):550-61. [Full Text/Abstract]
Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D. An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013; 4 (4; 2013):1813. [Full Text/Abstract]
Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R. Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations. J Biol Chem. 2012 Dec 28; 287 (2012 Dec 28; 287; 53):44546-60. [Full Text/Abstract]
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. Immunity. 2012 Dec 14; 37 (6; 37; 2012 Dec 14):971-85. [Full Text/Abstract]
Blackford JA Jr, Guo C, Zhu R, Dougherty EJ, Chow CC, Simons SS Jr. Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation. J Biol Chem. 2012 Nov 30; 287 (2012 Nov 30; 49; 287):40982-95. [Full Text/Abstract]
Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109 (109; 43; 2012 Oct 23):17603-8. [Full Text/Abstract]
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18; 109 (38; 109; 2012 Sep 18):15324-9. [Full Text/Abstract]
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. Thyroid. 2012 Aug; 22 (2012 Aug; 8; 22):839-43. [Full Text/Abstract]
Boutin A, Allen MD, Neumann S, Gershengorn MC. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB J. 2012 Aug; 26 (2012 Aug; 8; 26):3473-82. [Full Text/Abstract]
Ge K. Epigenetic regulation of adipogenesis by histone methylation. Biochim Biophys Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819):727-32. [Full Text/Abstract]
Forrest D, Swaroop A. Minireview: the role of nuclear receptors in photoreceptor differentiation and disease. Mol Endocrinol. 2012 Jun; 26 (2012 Jun; 6; 26):905-15. [Full Text/Abstract]
Awasthi S, Simons SS Jr. Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction. Mol Cell Endocrinol. 2012 May 15; 355 (2012 May 15; 355; 1):121-34. [Full Text/Abstract]
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D. Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones. Endocrinology. 2012 Mar; 153 (153; 2012 Mar; 3):1548-60. [Full Text/Abstract]
Simons SS Jr, Chow CC. The road less traveled: new views of steroid receptor action from the path of dose-response curves. Mol Cell Endocrinol. 2012 Jan 30; 348 (348; 2; 2012 Jan 30):373-82. [Full Text/Abstract]
Cho YW, Hong S, Ge K. Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex. Methods Mol Biol. 2012; 809 (2012; 809):465-72. [Full Text/Abstract]
Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res. 2012 Jan 1; 72 (72; 1; 2012 Jan 1):315-24. [Full Text/Abstract]
Dougherty EJ, Guo C, Simons SS Jr, Chow CC. Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification. PLoS One. 2012; 7 (2012; 7; 1):e30225. [Full Text/Abstract]