U.S. Department of Health and Human Services

Laboratory of Endocrinology and Receptor Biology

Marvin C. Gershengorn, M.D., Chief


A selection of recent and significant publications can be viewed below.

Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.Elife (Cambridge). 2013; 2 (0; 2; 2013) :e01503. [Full Text/Abstract]
Simons SS Jr, Edwards DP, Kumar R. Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges.Mol Endocrinol. 2013 Nov 27 (2013 Nov 27) . [Full Text/Abstract]
Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons SS Jr. A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties.J Biol Chem. 2013 Nov 22; 288 (288; 2013 Nov 22; 47) :34055-72. [Full Text/Abstract]
Simons SS Jr, Kumar R. Variable steroid receptor responses: Intrinsically disordered AF1 is the key.Mol Cell Endocrinol. 2013 Aug 25; 376 (376; 2013 Aug 25; 1-2) :81-4. [Full Text/Abstract]
Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D. An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons.Nat Commun. 2013; 4 (4; 2013) :1813. [Full Text/Abstract]
Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA Jr, Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.J Biol Chem. 2013 May 24; 288 (2013 May 24; 288; 21) :15167-80. [Full Text/Abstract]
Ng L, Kelley MW, Forrest D. Making sense with thyroid hormone--the role of T(3) in auditory development.Nat Rev Endocrinol. 2013 May; 9 (2013 May; 9; 5) :296-307. [Full Text/Abstract]
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.EMBO J. 2013 Jan 9; 32 (32; 2013 Jan 9; 1) :45-59. [Full Text/Abstract]
Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.J Biol Chem. 2013 Jan 4; 288 (2013 Jan 4; 288; 1) :42-58. [Full Text/Abstract]
Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D. Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1.Endocrinology. 2013 Jan; 154 (1; 2013 Jan; 154) :550-61. [Full Text/Abstract]
Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R. Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations.J Biol Chem. 2012 Dec 28; 287 (2012 Dec 28; 287; 53) :44546-60. [Full Text/Abstract]
Blackford JA Jr, Guo C, Zhu R, Dougherty EJ, Chow CC, Simons SS Jr. Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.J Biol Chem. 2012 Nov 30; 287 (2012 Nov 30; 49; 287) :40982-95. [Full Text/Abstract]
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.Proc Natl Acad Sci U S A. 2012 Sep 18; 109 (38; 109; 2012 Sep 18) :15324-9. [Full Text/Abstract]
Boutin A, Allen MD, Neumann S, Gershengorn MC. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.FASEB J. 2012 Aug; 26 (2012 Aug; 8; 26) :3473-82. [Full Text/Abstract]
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.Thyroid. 2012 Aug; 22 (2012 Aug; 8; 22) :839-43. [Full Text/Abstract]
Ge K. Epigenetic regulation of adipogenesis by histone methylation.Biochim Biophys Acta. 2012 Jul; 1819 (7; 2012 Jul; 1819) :727-32. [Full Text/Abstract]
Forrest D, Swaroop A. Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.Mol Endocrinol. 2012 Jun; 26 (2012 Jun; 6; 26) :905-15. [Full Text/Abstract]
Awasthi S, Simons SS Jr. Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction.Mol Cell Endocrinol. 2012 May 15; 355 (2012 May 15; 355; 1) :121-34. [Full Text/Abstract]
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D. Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones.Endocrinology. 2012 Mar; 153 (153; 2012 Mar; 3) :1548-60. [Full Text/Abstract]
Simons SS Jr, Chow CC. The road less traveled: new views of steroid receptor action from the path of dose-response curves.Mol Cell Endocrinol. 2012 Jan 30; 348 (348; 2; 2012 Jan 30) :373-82. [Full Text/Abstract]
Sharlin DS, Visser TJ, Forrest D. Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.Endocrinology. 2011 Dec; 152 (152; 12; 2011 Dec) :5053-64. [Full Text/Abstract]
Alberobello AT, Congedo V, Liu H, Cochran C, Skarulis MC, Forrest D, Celi FS. An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone.J Transl Med. 2011 Aug 26; 9 (2011 Aug 26; 9) :144. [Full Text/Abstract]
Ng L, Lu A, Swaroop A, Sharlin DS, Swaroop A, Forrest D. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.J Neurosci. 2011 Aug 3; 31 (2011 Aug 3; 31) :11118-25. [Full Text/Abstract]
Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence.Thyroid. 2011 Aug; 21 (8; 21; 2011 Aug) :907-12. [Full Text/Abstract]
Boutin A, Allen MD, Geras-Raaka E, Huang W, Neumann S, Gershengorn MC. Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling.Mol Pharmacol. 2011 Aug; 80 (2; 80; 2011 Aug) :240-6. [Full Text/Abstract]
Monga V, Meena CL, Rajput S, Pawar C, Sharma SS, Lu X, Gershengorn MC, Jain R. Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues.ChemMedChem. 2011 Mar 7; 6 (6; 2011 Mar 7; 3) :531-43. [Full Text/Abstract]
Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.J Clin Endocrinol Metab. 2011 Feb; 96 (2; 2011 Feb; 96) :548-54. [Full Text/Abstract]
Lee GS, Simons SS Jr. Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors.Biochemistry. 2011 Jan 25; 50 (50; 2011 Jan 25; 3) :356-66. [Full Text/Abstract]
Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.EMBO J. 2011 Jan 19; 30 (30; 2; 2011 Jan 19) :249-62. [Full Text/Abstract]
Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G. Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.Cell Mol Life Sci. 2011 Jan; 68 (68; 2011 Jan; 1) :159-67. [Full Text/Abstract]