U.S. Department of Health and Human Services

Laboratory of Endocrinology and Receptor Biology

Marvin C. Gershengorn, M.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY. Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol. 2014 Jul 28; 34 (19):3746-53. [Full Text/Abstract]
Katz LS, Geras-Raaka E, Gershengorn MC. Heritability of fat accumulation in white adipocytes. Am J Physiol Endocrinol Metab. 2014 Aug 1; 307 (3):E335-44. [Full Text/Abstract]
Boutin A, Eliseeva E, Gershengorn MC, Neumann S. β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. FASEB J. 2014 Aug; 28 (8):3446-55. [Full Text/Abstract]
Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr. Research Resource: Modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Mol Endocrinol. 2014 Jul; 28 (7):me20141069. [Full Text/Abstract]
Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul; 243 (7):937-47. [Full Text/Abstract]
Hiram-Bab S, Katz LS, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol. 2014 Jun; 229 (6):743-51. [Full Text/Abstract]
Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr. A kinase-independent activity of cdk9 modulates glucocorticoid receptor-mediated gene induction. Biochemistry. 2014 Mar 25; 53 (11):1753-67. [Full Text/Abstract]
Krieger CC, Gershengorn MC. A modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cells. Endocrinology. 2014 Feb; 155 (2):627-34. [Full Text/Abstract]
Simons SS Jr, Edwards DP, Kumar R. Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges. Mol Endocrinol. 2014 Feb; 28 (2):173-82. [Full Text/Abstract]
Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan; 155 (1):310-4. [Full Text/Abstract]
Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013 Dec 24; 2 (0):e01503. [Full Text/Abstract]
Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons SS Jr. A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties. J Biol Chem. 2013 Nov 22; 288 (47):34055-72. [Full Text/Abstract]
Simons SS Jr, Kumar R. Variable steroid receptor responses: Intrinsically disordered AF1 is the key. Mol Cell Endocrinol. 2013 Aug 25; 376 (1-2):81-4. [Full Text/Abstract]
Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA Jr, Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. J Biol Chem. 2013 May 24; 288 (21):15167-80. [Full Text/Abstract]
Ng L, Kelley MW, Forrest D. Making sense with thyroid hormone--the role of T(3) in auditory development. Nat Rev Endocrinol. 2013 May; 9 (5):296-307. [Full Text/Abstract]
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis. EMBO J. 2013 Jan 9; 32 (1):45-59. [Full Text/Abstract]
Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. J Biol Chem. 2013 Jan 4; 288 (1):42-58. [Full Text/Abstract]
Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D. Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1. Endocrinology. 2013 Jan; 154 (1):550-61. [Full Text/Abstract]
Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D. An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013; 4 :1813. [Full Text/Abstract]
Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R. Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations. J Biol Chem. 2012 Dec 28; 287 (53):44546-60. [Full Text/Abstract]
Blackford JA Jr, Guo C, Zhu R, Dougherty EJ, Chow CC, Simons SS Jr. Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation. J Biol Chem. 2012 Nov 30; 287 (49):40982-95. [Full Text/Abstract]
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18; 109 (38):15324-9. [Full Text/Abstract]
Boutin A, Allen MD, Neumann S, Gershengorn MC. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB J. 2012 Aug; 26 (8):3473-82. [Full Text/Abstract]
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. Thyroid. 2012 Aug; 22 (8):839-43. [Full Text/Abstract]
Ge K. Epigenetic regulation of adipogenesis by histone methylation. Biochim Biophys Acta. 2012 Jul; 1819 (7):727-32. [Full Text/Abstract]
Forrest D, Swaroop A. Minireview: the role of nuclear receptors in photoreceptor differentiation and disease. Mol Endocrinol. 2012 Jun; 26 (6):905-15. [Full Text/Abstract]
Awasthi S, Simons SS Jr. Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction. Mol Cell Endocrinol. 2012 May 15; 355 (1):121-34. [Full Text/Abstract]
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D. Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones. Endocrinology. 2012 Mar; 153 (3):1548-60. [Full Text/Abstract]
Simons SS Jr, Chow CC. The road less traveled: new views of steroid receptor action from the path of dose-response curves. Mol Cell Endocrinol. 2012 Jan 30; 348 (2):373-82. [Full Text/Abstract]
Cho YW, Hong S, Ge K. Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex. Methods Mol Biol. 2012; 809 :465-72. [Full Text/Abstract]