U.S. Department of Health and Human Services

Laboratory of Endocrinology and Receptor Biology

Marvin C. Gershengorn, M.D., Chief

​Research Images

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PTIPPTIP associates with histone H3K4 methyltransferases MLL3/MLL4 and H3K27 demethylase UTXPTIPEnlarge
TSH receptor model with ligand binding sitesComposite 3-dimensional homology model of the TSH receptor (magenta) with the amino-terminal ectodomain above and transmembrane helical domain below illustrates distinct binding sites for TSH (gray) and a small molecule agonist (orange). A 140-amino acid sequence of unknown structure is represented by a dotted line.TSH receptor model with ligand binding sitesEnlarge
Ligand binding to thyroid-stimulating hormone (TSH) receptorThe thyroid-stimulating hormone (TSH), autoantibodies (TSAbs), and small molecule drug-like ligands (SMLs) bind to the TSH receptor at different sites. TSH and TSAbs bind primarily to the large ectodomain, whereas SMLs bind to a pocket within the transmembrane domain. Ectodomain is in red while the Transmembrane domain’s individual helices are ribbons in different colors.Ligand binding to thyroid-stimulating hormone (TSH) receptorEnlarge
Internalization of thyroid-stimulating hormone (TSH) receptorsThyroid-stimulating hormone (TSH) receptors (TSHRs) are stimulated to internalize by TSH in a β-arrestin-2-mediated pathway. Internalization of TSHRs (Control cells) are internalized to a greater extent when β-arrestin-2 is co-expressed with TSHRs (β-arrestin-2). The punctate spots are clusters of internalized TSHRs.Internalization of thyroid-stimulating hormone (TSH) receptorsEnlarge
The ossicles of the mouse middle earThe ossicles consist of three bones, the malleus, incus, and stapes (blue, immature cartilage; red, calcified bone). The ossicles in the middle ear relay the mechanical energy of sound from the outer ear to the inner ear. The development of the the ossicles is influenced by thyroid hormone. Picture by Emily CordasThe ossicles of the mouse middle earEnlarge