U.S. Department of Health and Human Services

Laboratory of Genetics and Physiology

Lothar Hennighausen, Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Bae WK, Yoo KH, Lee JS, Kim Y, Chung IJ, Park MH, Yoon JH, Furth PA, Hennighausen L. The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers. Mol Carcinog. 2014 Jul 7; (2014 Jul 7). [Full Text/Abstract]
Robinson GW, Kang K, Yoo KH, Tang Y, Zhu BM, Yamaji D, Colditz V, Jang SJ, Gronostajski RM, Hennighausen L. Co-regulation of genetic programs by the transcription factors NFIB and STAT5. Mol Endocrinol. 2014 May; 28 (28; 2014 May; 5):me20121387. [Full Text/Abstract]
Kang K, Yamaji D, Yoo KH, Robinson GW, Hennighausen L. Mammary-specific gene activation is defined by progressive recruitment of STAT5 during pregnancy and the establishment of H3K4me3 marks. Mol Cell Biol. 2014 Feb; 34 (2014 Feb; 3; 34):464-73. [Full Text/Abstract]
Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S. Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast. J Exp Med. 2014 Jan 13; 211 (211; 2014 Jan 13; 1):153-63. [Full Text/Abstract]
Feuermann Y, Kang K, Gavrilova O, Haetscher N, Jang SJ, Yoo KH, Jiang C, Gonzalez FJ, Robinson GW, Hennighausen L. MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse. RNA Biol. 2013 Dec 1; 10 (2013 Dec 1; 12; 10):1807-14. [Full Text/Abstract]
Yamaji D, Kang K, Robinson GW, Hennighausen L. Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration. Nucleic Acids Res. 2013 Feb 1; 41 (2013 Feb 1; 41; 3):1622-36. [Full Text/Abstract]
Kang K, Robinson GW, Hennighausen L. Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules. BMC Genomics. 2013 Jan 16; 14 (14; 2013 Jan 16):4. [Full Text/Abstract]
Yu JH, Zhu BM, Riedlinger G, Kang K, Hennighausen L. The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. Hepatology. 2012 Dec; 56 (2012 Dec; 56; 6):2375-86. [Full Text/Abstract]
Zhu BM, Kang K, Yu JH, Chen W, Smith HE, Lee D, Sun HW, Wei L, Hennighausen L. Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes. Nucleic Acids Res. 2012 May; 40 (40; 2012 May; 10):4461-72. [Full Text/Abstract]
Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, Hennighausen L. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia. 2010 Nov; 12 (2010 Nov; 12; 11):899-905. [Full Text/Abstract]
Yu JH, Zhu BM, Wickre M, Riedlinger G, Chen W, Hosui A, Robinson GW, Hennighausen L. The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. Hepatology. 2010 Nov; 52 (2010 Nov; 5; 52):1808-18. [Full Text/Abstract]
Kimura A, Martin C, Robinson GW, Simone JM, Chen W, Wickre MC, O'Shea JJ, Hennighausen L. The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B. J Biol Chem. 2010 Oct 22; 285 (2010 Oct 22; 43; 285):32704-9. [Full Text/Abstract]
Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson GW, Hennighausen L. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev. 2009 Oct 15; 23 (2009 Oct 15; 20; 23):2382-7. [Full Text/Abstract]
Zhu BM, McLaughlin SK, Na R, Liu J, Cui Y, Martin C, Kimura A, Robinson GW, Andrews NC, Hennighausen L. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008 Sep 1; 112 (5; 112; 2008 Sep 1):2071-80. [Full Text/Abstract]
Hennighausen L, Robinson GW. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev. 2008 Mar 15; 22 (6; 2008 Mar 15; 22):711-21. [Full Text/Abstract]
Cui Y, Hosui A, Sun R, Shen K, Gavrilova O, Chen W, Cam MC, Gao B, Robinson GW, Hennighausen L. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology. 2007 Aug; 46 (46; 2007 Aug; 2):504-13. [Full Text/Abstract]
Hennighausen L, Robinson GW. Information networks in the mammary gland. Nat Rev Mol Cell Biol. 2005 Sep; 6 (6; 9; 2005 Sep):715-25. [Full Text/Abstract]
Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX, Robinson GW, Hennighausen L. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004 Sep; 24 (24; 18; 2004 Sep):8037-47. [Full Text/Abstract]
Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K, Hennighausen L. Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol Endocrinol. 2002 Mar; 16 (16; 2002 Mar; 3):563-70. [Full Text/Abstract]