U.S. Department of Health and Human Services

Laboratory of Genetics and Physiology

Lothar Hennighausen, Ph.D., Chief

​Resources

Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

Resource Name Description
Animal Models to Study Mammary Gland Development, Physiology, and Tumorigenesis

A guide to animal models which have been used to study molecular mechanisms of Mammary Gland Development, Physiology and Tumorigenesis.

Stat5a KO(Stat5a tm1Mam) Mouse (Mutant Mouse: Stat 5a (Signal transducer and activator of transcription))

Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis.

Prolactin induces mammary gland development and lactogenesis.  Binding of Prolactin to its receptor leads to the phosphorylation…

Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse (Mutant Mouse: Bcl2l1(Bcl2-like 1))

Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-aptoptotic Bax during embryogenesis.

Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which…

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse (Mutant Mouse: Stat5a/b)

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.

The signal transducer and activator of transcription (STAT…

Tg(MMTV-Cre)#Mam Mouse (Mutant Mouse: MMTV-Cre (Mammary tumor virus long terminal repeat-Cre recombinase))

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues.

The Cre recombinase from bacteriophage…

Tg(Wap-cre)11738Mam Mouse (Mutant Mouse: WAP-Cre (whey acidic protein promoter directs Cre recombinase))

Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development.

The Cre recombinase from…

Stat1LoxP (Stat1 tm1Mam) Mouse (Mutant Mouse: Stat1)

Selective inactivation of Stat 1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.

STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by…

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Clinical Trials

Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.

Study Title
There are no associated clinical trials.
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