U.S. Department of Health and Human Services

Laboratory of Molecular Biology

Susan K. Buchanan, Ph.D., Chief

​About the Lab/Branch

The Laboratory of Molecular Biology brings together scientists with a broad range of expertise in biological structure and function. In this environment, geneticists, biochemists, and developmental biologists interact with physical chemists and structural biologists to address problems of mutual interest.

​Current Research

Scientists in the lab study diverse topics in biology. These include:

  • the transcriptional regulation of cell fate determination during metazoan development;
  • the mechanisms underlying cellular processes that impact the genomic structure and the heritance of the genomic material;
  • DNA recombination, repair, and replication;
  • the rearrangement of immunoglobulin and T-cell receptor genes (known as V(D)J recombination);
  • mechanistic aspects of retroviral DNA integration;
  • the structure and function of several types of proteins;
  • the structure determination of integral membrane proteins by x-ray crystallography and functional analysis of these proteins using biophysical, biochemical, and cell biological techniques; and
  • determining the structure of integral membrane proteins.