U.S. Department of Health and Human Services

Molecular Medicine Branch

Alan Neil Schechter, M.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Glushakova S, Balaban A, McQueen PG, Coutinho R, Miller JL, Nossal R, Fairhurst RM, Zimmerberg J. Hemoglobinopathic erythrocytes affect the intraerythrocytic multiplication of Plasmodium falciparum in vitro. J Infect Dis. 2014 May 5; 210 (210; 7; 2014 May 5):1100-9. [Full Text/Abstract]
Meier ER, Wright EC, Miller JL. Reticulocytosis and anemia are associated with an increased risk of death and stroke in the newborn cohort of the Cooperative Study of Sickle Cell Disease. Am J Hematol. 2014 Sep; 89 (9; 2014 Sep; 89):904-6. [Full Text/Abstract]
Wang L, Di L, Noguchi CT. AMPK is Involved in Mediation of Erythropoietin Influence on Metabolic Activity and Reactive Oxygen Species Production in White Adipocytes. Int J Biochem Cell Biol. 2014 Jun 19; 54 (2014 Jun 19; 54):1-9. [Full Text/Abstract]
Park JW, Piknova B, Nghiem K, Lozier JN, Schechter AN. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide. 2014 Aug 31; 40 (40; 2014 Aug 31):45-51. [Full Text/Abstract]
Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ. Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor. Blood. 2014 Aug 7; 124 (124; 6; 2014 Aug 7):946-54. [Full Text/Abstract]
Alnaeeli M, Raaka BM, Gavrilova O, Teng R, Chanturiya T, Noguchi CT. Erythropoietin signaling: A novel regulator of white adipose tissue inflammation during diet-induced obesity. Diabetes. 2014 Jul; 63 (7; 63; 2014 Jul):2415-31. [Full Text/Abstract]
Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT. Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism. Int J Mol Sci. 2014 Jun 10; 15 (6; 15; 2014 Jun 10):10296-10333. [Full Text/Abstract]
Cokic BB, Cokic VP, Suresh S, Wirt S, Noguchi CT. Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells. Microvasc Res. 2014 Mar; 92 (2014 Mar; 92):34-40. [Full Text/Abstract]
Lee YT, de Vasconcellos JF, Yuan J, Byrnes C, Noh SJ, Meier ER, Kim KS, Rabel A, Kaushal M, Muljo SA, Miller JL. LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. Blood. 2013 Aug 8; 122 (122; 6; 2013 Aug 8):1034-41. [Full Text/Abstract]
Lee YT, Kim KS, Byrnes C, de Vasconcellos JF, Noh SJ, Rabel A, Meier ER, Miller JL. A Synthetic Model of Human Beta-Thalassemia Erythropoiesis Using CD34+ Cells from Healthy Adult Donors. PLoS One. 2013; 8 (8; 7; 2013):e68307. [Full Text/Abstract]
Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med. 2013 Jul 1; 3 (7; 3; 2013 Jul 1). [Full Text/Abstract]
Byrnes C, Lee YT, Meier ER, Rabel A, Sacks DB, Miller JL. Iron dose-dependent differentiation and enucleation of human erythroblasts in serum-free medium. J Tissue Eng Regen Med. 2013 Apr 18; (2013 Apr 18). [Full Text/Abstract]
Park JW, Piknova B, Kurtz J, Seetharaman S, Wagner SJ, Schechter AN. Effect of storage on levels of nitric oxide metabolites in platelet preparations. Transfusion. 2013 Mar; 53 (2013 Mar; 3; 53):637-44. [Full Text/Abstract]
Meier ER, Byrnes C, Lee YT, Wright EC, Schechter AN, Luban NL, Miller JL. Increased Reticulocytosis during Infancy Is Associated with Increased Hospitalizations in Sickle Cell Anemia Patients during the First Three Years of Life. PLoS One. 2013; 8 (8; 2013):e70794. [Full Text/Abstract]
Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem. 2012 Oct 26; 287 (287; 2012 Oct 26; 44):36720-31. [Full Text/Abstract]
Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT. GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1). J Biol Chem. 2012 Aug 31; 287 (287; 36; 2012 Aug 31):30157-69. [Full Text/Abstract]
Jia Y, Suzuki N, Yamamoto M, Gassmann M, Noguchi CT. Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage. FASEB J. 2012 Jul; 26 (7; 2012 Jul; 26):2847-58. [Full Text/Abstract]
Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN. JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. J Transl Med. 2012 Jun 7; 10 (2012 Jun 7; 10):116. [Full Text/Abstract]
Machha A, Schechter AN. Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables?. Nutr Rev. 2012 Jun; 70 (2012 Jun; 6; 70):367-72. [Full Text/Abstract]
Meier ER, Miller JL. Sickle cell disease in children. Drugs. 2012 May 7; 72 (72; 7; 2012 May 7):895-906. [Full Text/Abstract]
Byrnes C, Terry Lee Y, Donahue RE, Miller JL. Identification of a cross-reacting, monoclonal anti-human CD233 antibody for identification and sorting of rhesus macaque erythrocytes. Cytometry A. 2012 Feb; 81 (81; 2012 Feb; 2):165-8. [Full Text/Abstract]
Srihirun S, Sriwantana T, Unchern S, Kittikool D, Noulsri E, Pattanapanyasat K, Fucharoen S, Piknova B, Schechter AN, Sibmooh N. Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation. PLoS One. 2012; 7 (2012; 7; 1):e30380. [Full Text/Abstract]
Kiefer CM, Lee J, Hou C, Dale RK, Lee YT, Meier ER, Miller JL, Dean A. Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood. 2011 Dec 1; 118 (118; 23; 2011 Dec 1):6200-8. [Full Text/Abstract]
Abraham B, Hicks W, Jia Y, Baek JH, Miller JL, Alayash AI. Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions. Biochemistry. 2011 Nov 15; 50 (50; 45; 2011 Nov 15):9752-66. [Full Text/Abstract]
Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT. Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production. Nat Commun. 2011 Nov 1; 2 (2; 2011 Nov 1):520. [Full Text/Abstract]
Piknova B, Kocharyan A, Schechter AN, Silva AC. The role of nitrite in neurovascular coupling. Brain Res. 2011 Aug 17; 1407 (1407; 2011 Aug 17):62-8. [Full Text/Abstract]
Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr. 2011 Aug; 50 (50; 2011 Aug; 5):293-303. [Full Text/Abstract]
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Res Cardiol. 2011 May; 106 (106; 3; 2011 May):343-54. [Full Text/Abstract]
Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT. Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells. Cytokine. 2011 May; 54 (2; 54; 2011 May):129-35. [Full Text/Abstract]
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Res Cardiol. 2011 May; 106 (106; 3; 2011 May):343-54. [Full Text/Abstract]
Tanno T, Rabel A, Alleyne M, Lee YT, Dahut WL, Gulley JL, Miller JL. Hepcidin, anaemia, and prostate cancer. BJU Int. 2011 Feb; 107 (107; 2011 Feb; 4):678-9. [Full Text/Abstract]
Piknova B, Schechter AN. Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay. Methods Mol Biol. 2011; 704 (704; 2011):39-56. [Full Text/Abstract]
Meier ER, Byrnes C, Weissman M, Noel P, Luban NL, Miller JL. Expression patterns of fetal hemoglobin in sickle cell erythrocytes are both patient- and treatment-specific during childhood. Pediatr Blood Cancer. 2011 Jan; 56 (56; 2011 Jan; 1):103-9. [Full Text/Abstract]
Noh SJ, Lee YT, Byrnes C, Miller JL. A transcriptome-based examination of blood group expression. Transfus Clin Biol. 2010 Sep; 17 (17; 2010 Sep; 3):120-5. [Full Text/Abstract]
Tanno T, Rabel A, Lee YT, Yau YY, Leitman SF, Miller JL. Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation. Transfusion. 2010 Jul; 50 (7; 50; 2010 Jul):1532-5. [Full Text/Abstract]
Tanno T, Noel P, Miller JL. Growth differentiation factor 15 in erythroid health and disease. Curr Opin Hematol. 2010 May; 17 (17; 2010 May; 3):184-90. [Full Text/Abstract]
Tanno T, Miller JL. Iron Loading and Overloading due to Ineffective Erythropoiesis. Adv Hematol. 2010; 2010 (2010):358283. [Full Text/Abstract]
Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 2009 Dec; 5 (12; 5; 2009 Dec):865-9. [Full Text/Abstract]
Noh SJ, Miller SH, Lee YT, Goh SH, Marincola FM, Stroncek DF, Reed C, Wang E, Miller JL. Let-7 microRNAs are developmentally regulated in circulating human erythroid cells. J Transl Med. 2009 Nov 25; 7 (2009 Nov 25; 7):98. [Full Text/Abstract]
Cokić VP, Beleslin-Cokić BB, Smith RD, Economou AP, Wahl LM, Noguchi CT, Schechter AN. Stimulated stromal cells induce gamma-globin gene expression in erythroid cells via nitric oxide production. Exp Hematol. 2009 Oct; 37 (2009 Oct; 37; 10):1230-7. [Full Text/Abstract]
Sripichai O, Kiefer CM, Bhanu NV, Tanno T, Noh SJ, Goh SH, Russell JE, Rognerud CL, Ou CN, Oneal PA, Meier ER, Gantt NM, Byrnes C, Lee YT, Dean A, Miller JL. Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood. 2009 Sep 10; 114 (2009 Sep 10; 114; 11):2299-306. [Full Text/Abstract]
Jia Y, Warin R, Yu X, Epstein R, Noguchi CT. Erythropoietin signaling promotes transplanted progenitor cell survival. FASEB J. 2009 Sep; 23 (23; 9; 2009 Sep):3089-99. [Full Text/Abstract]
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009 Jul 2; 114 (114; 2009 Jul 2; 1):181-6. [Full Text/Abstract]
Piknova B, Keszler A, Hogg N, Schechter AN. The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide. 2009 Mar; 20 (20; 2; 2009 Mar):88-94. [Full Text/Abstract]
Tamary H, Shalev H, Perez-Avraham G, Zoldan M, Levi I, Swinkels DW, Tanno T, Miller JL. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood. 2008 Dec 15; 112 (2008 Dec 15; 13; 112):5241-4. [Full Text/Abstract]
Noguchi CT, Wang L, Rogers HM, Teng R, Jia Y. Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev Mol Med. 2008 Dec 1; 10 (2008 Dec 1; 10):e36. [Full Text/Abstract]
Schechter AN. Hemoglobin research and the origins of molecular medicine. Blood. 2008 Nov 15; 112 (2008 Nov 15; 10; 112):3927-38. [Full Text/Abstract]
Alleyne M, Horne MK, Miller JL. Individualized treatment for iron-deficiency anemia in adults. Am J Med. 2008 Nov; 121 (121; 2008 Nov; 11):943-8. [Full Text/Abstract]
Keszler A, Piknova B, Schechter AN, Hogg N. The reaction between nitrite and oxyhemoglobin: a mechanistic study. J Biol Chem. 2008 Apr 11; 283 (283; 15; 2008 Apr 11):9615-22. [Full Text/Abstract]
Sibmooh N, Piknova B, Rizzatti F, Schechter AN. Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes. Biochemistry. 2008 Mar 4; 47 (2008 Mar 4; 9; 47):2989-96. [Full Text/Abstract]