U.S. Department of Health and Human Services

Molecular Medicine Branch

Alan Neil Schechter, M.D., Chief


A selection of recent and significant publications can be viewed below.

Park JW, Piknova B, Kurtz J, Seetharaman S, Wagner SJ, Schechter AN. Effect of storage on levels of nitric oxide metabolites in platelet preparations.Transfusion. 2013 Mar; 53 (2013 Mar; 3; 53) :637-44. [Full Text/Abstract]
Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.J. Biol. Chem. 2012 Oct 26; 287 (287; 2012 Oct 26; 44) :36720-31. [Full Text/Abstract]
Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT. GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).J. Biol. Chem. 2012 Aug 31; 287 (287; 36; 2012 Aug 31) :30157-69. [Full Text/Abstract]
Jia Y, Suzuki N, Yamamoto M, Gassmann M, Noguchi CT. Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage.FASEB J. 2012 Jul; 26 (7; 2012 Jul; 26) :2847-58. [Full Text/Abstract]
Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN. JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny.J Transl Med. 2012 Jun 7; 10 (2012 Jun 7; 10) :116. [Full Text/Abstract]
Machha A, Schechter AN. Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables?Nutr. Rev. 2012 Jun; 70 (2012 Jun; 6; 70) :367-72. [Full Text/Abstract]
Byrnes C, Terry Lee Y, Donahue RE, Miller JL. Identification of a cross-reacting, monoclonal anti-human CD233 antibody for identification and sorting of rhesus macaque erythrocytes.Cytometry A. 2012 Feb; 81 (81; 2012 Feb; 2) :165-8. [Full Text/Abstract]
Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT. Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production.Nat Commun. 2011 Nov 1; 2 (2; 2011 Nov 1) :520. [Full Text/Abstract]
Piknova B, Kocharyan A, Schechter AN, Silva AC. The role of nitrite in neurovascular coupling.Brain Res. 2011 Aug 17; 1407 (1407; 2011 Aug 17) :62-8. [Full Text/Abstract]
Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits.Eur J Nutr. 2011 Aug; 50 (50; 2011 Aug; 5) :293-303. [Full Text/Abstract]
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response.Basic Res. Cardiol. 2011 May; 106 (106; 3; 2011 May) :343-54. [Full Text/Abstract]
Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT. Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells.Cytokine. 2011 May; 54 (2; 54; 2011 May) :129-35. [Full Text/Abstract]
Tanno T, Rabel A, Alleyne M, Lee YT, Dahut WL, Gulley JL, Miller JL. Hepcidin, anaemia, and prostate cancer.BJU Int. 2011 Feb; 107 (107; 2011 Feb; 4) :678-9. [Full Text/Abstract]
Meier ER, Byrnes C, Weissman M, Noel P, Luban NL, Miller JL. Expression patterns of fetal hemoglobin in sickle cell erythrocytes are both patient- and treatment-specific during childhood.Pediatr Blood Cancer. 2011 Jan; 56 (56; 2011 Jan; 1) :103-9. [Full Text/Abstract]
Tanno T, Rabel A, Lee YT, Yau YY, Leitman SF, Miller JL. Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation.Transfusion. 2010 Jul; 50 (7; 50; 2010 Jul) :1532-5. [Full Text/Abstract]
Tanno T, Noel P, Miller JL. Growth differentiation factor 15 in erythroid health and disease.Curr. Opin. Hematol. 2010 May; 17 (17; 2010 May; 3) :184-90. [Full Text/Abstract]
Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics.Nat. Chem. Biol. 2009 Dec; 5 (12; 5; 2009 Dec) :865-9. [Full Text/Abstract]
Noh SJ, Miller SH, Lee YT, Goh SH, Marincola FM, Stroncek DF, Reed C, Wang E, Miller JL. Let-7 microRNAs are developmentally regulated in circulating human erythroid cells.J Transl Med. 2009 Nov 25; 7 (2009 Nov 25; 7) :98. [Full Text/Abstract]
Cokić VP, Beleslin-Cokić BB, Smith RD, Economou AP, Wahl LM, Noguchi CT, Schechter AN. Stimulated stromal cells induce gamma-globin gene expression in erythroid cells via nitric oxide production.Exp. Hematol. 2009 Oct; 37 (2009 Oct; 37; 10) :1230-7. [Full Text/Abstract]
Sripichai O, Kiefer CM, Bhanu NV, Tanno T, Noh SJ, Goh SH, Russell JE, Rognerud CL, Ou CN, Oneal PA, Meier ER, Gantt NM, Byrnes C, Lee YT, Dean A, Miller JL. Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming.Blood. 2009 Sep 10; 114 (2009 Sep 10; 114; 11) :2299-306. [Full Text/Abstract]
Jia Y, Warin R, Yu X, Epstein R, Noguchi CT. Erythropoietin signaling promotes transplanted progenitor cell survival.FASEB J. 2009 Sep; 23 (23; 9; 2009 Sep) :3089-99. [Full Text/Abstract]
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.Blood. 2009 Jul 2; 114 (114; 2009 Jul 2; 1) :181-6. [Full Text/Abstract]
Piknova B, Keszler A, Hogg N, Schechter AN. The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies.Nitric Oxide. 2009 Mar; 20 (20; 2; 2009 Mar) :88-94. [Full Text/Abstract]
Tamary H, Shalev H, Perez-Avraham G, Zoldan M, Levi I, Swinkels DW, Tanno T, Miller JL. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I.Blood. 2008 Dec 15; 112 (2008 Dec 15; 13; 112) :5241-4. [Full Text/Abstract]
Noguchi CT, Wang L, Rogers HM, Teng R, Jia Y. Survival and proliferative roles of erythropoietin beyond the erythroid lineage.Expert Rev Mol Med. 2008 Dec 1; 10 (2008 Dec 1; 10) :e36. [Full Text/Abstract]
Schechter AN. Hemoglobin research and the origins of molecular medicine.Blood. 2008 Nov 15; 112 (2008 Nov 15; 10; 112) :3927-38. [Full Text/Abstract]
Alleyne M, Horne MK, Miller JL. Individualized treatment for iron-deficiency anemia in adults.Am. J. Med. 2008 Nov; 121 (121; 2008 Nov; 11) :943-8. [Full Text/Abstract]
Keszler A, Piknova B, Schechter AN, Hogg N. The reaction between nitrite and oxyhemoglobin: a mechanistic study.J. Biol. Chem. 2008 Apr 11; 283 (283; 15; 2008 Apr 11) :9615-22. [Full Text/Abstract]
Sibmooh N, Piknova B, Rizzatti F, Schechter AN. Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes.Biochemistry. 2008 Mar 4; 47 (2008 Mar 4; 9; 47) :2989-96. [Full Text/Abstract]