Specific scientific interests of the Branch’s investigators include: (1) glucose homeostasis, beta cell function and growth, insulin resistance, and the abnormalities that are found in type 1 and type 2 diabetes; (2) energy homeostasis, fat cell development and function, and the abnormalities that are found in obesity; (3) immune-tolerance induction in the context of autoimmune (type 1) diabetes; (4) thyroid-hormone physiology in normal and disease states; (5) developing and validating animal models to study endocrinology and glucose and energy homeostasis; (6) neurological function (and dysfunction) associated with food consumption, metabolism, and energy homeostasis; and (7) endocrinology, neuroendocrinology, and metabolism assessed through physiologic and observational studies and pharmacologic intervention trials conducted with healthy volunteers and individuals with diseases of interest. In addition, the Branch is deeply committed to training physicians in the subspecialties of endocrinology, diabetes, and metabolism, and the conduct of clinical research.
The goal of this increased understanding is to advance the treatment of diabetes, obesity, and other endocrine diseases.
Diabetes, obesity, and other endocrine diseases are major public health problems that cause significant morbidity, mortality, and health costs. Advances in our understanding of these diseases and treatments will benefit a large fraction of the population of the United States and the world.
The Diabetes, Endocrinology, and Obesity Branch also supports research through the Metabolic Clinical Research Unit (MCRU).