U.S. Department of Health and Human Services

Diabetes, Endocrinology, and Obesity Branch

Marc L. Reitman, M.D., Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Cypess AM, Weiner LS, Roberts-Toler C, Franquet Elía E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015 Jan 6; 21 (2015 Jan 6; 21; 1):33-8. [Full Text/Abstract]
Fernandez P, Scaffidi P, Markert E, Lee JH, Rane S, Misteli T. Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. Cell Rep. 2014 Oct 1; 9 (2014 Oct 1; 9; 1):248-60. [Full Text/Abstract]
Irving WL, Rupp D, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ. Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res. 2014 Jul 22; 110 (110; 2014 Jul 22):52-9. [Full Text/Abstract]
Rahman MM, Kim KH, Brown RJ, Bae IS, Park CG. PCDD and PCDF concentrations in a traffic tunnel environment. Sci Total Environ. 2014 Sep 15; 493 (493; 2014 Sep 15):773-80. [Full Text/Abstract]
Cypess AM, Haft CR, Laughlin MR, Hu HH. Brown fat in humans: consensus points and experimental guidelines. Cell Metab. 2014 Sep 2; 20 (20; 2014 Sep 2; 3):408-15. [Full Text/Abstract]
Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ. Lipid Regulation in Lipodystrophy Versus the Obesity-Associated Metabolic Syndrome: The Dissociation of HDL-C and Triglycerides. J Clin Endocrinol Metab. 2014 Jun 13; 99 (99; 2014 Jun 13; 9):E1676-80. [Full Text/Abstract]
Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes Cancer. 2014 Sep; 5 (9-10; 5; 2014 Sep):306-19. [Full Text/Abstract]
Srinivasa S, Wong K, Fitch KV, Wei J, Petrow E, Cypess AM, Torriani M, Grinspoon SK. Effects of lifestyle modification and metformin on irisin and FGF21 among HIV-infected subjects with the metabolic syndrome. Clin Endocrinol (Oxf). 2014 Aug 16; 82 (2014 Aug 16; 82; 5):678-85. [Full Text/Abstract]
Karunasena HC, Senadeera W, Brown RJ, Gu YT. A particle based model to simulate microscale morphological changes of plant tissues during drying. Soft Matter. 2014 Aug 7; 10 (2014 Aug 7; 10; 29):5249-68. [Full Text/Abstract]
Quétel CR, Zampella M, Brown RJ, Ent H, Horvat M, Paredes E, Tunc M. International system of units traceable results of Hg mass concentration at saturation in air from a newly developed measurement procedure. Anal Chem. 2014 Aug 5; 86 (86; 2014 Aug 5; 15):7819-27. [Full Text/Abstract]
Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5; 20 (20; 2014 Aug 5; 2):333-45. [Full Text/Abstract]
Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest. 2014 Aug 1; 124 (124; 8; 2014 Aug 1):3339-51. [Full Text/Abstract]
O'Connor MY, Thoreson CK, Ricks M, Courville AB, Thomas F, Yao J, Katzmarzyk PT, Sumner AE. Worse cardiometabolic health in African immigrant men than African American men: reconsideration of the healthy immigrant effect. Metab Syndr Relat Disord. 2014 Aug; 12 (6; 2014 Aug; 12):347-53. [Full Text/Abstract]
Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Behrendt P, Brown RJ, Ciesek S, Wedemeyer H, Sarrazin C, Kaderali L, Pietschmann T, Steinmann E. Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles. Hepatology. 2014 Aug; 60 (2; 2014 Aug; 60):508-20. [Full Text/Abstract]
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30; 6 (6; 247; 2014 Jul 30):247ra103. [Full Text/Abstract]
Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality. J Biol Chem. 2014 Jul 11; 289 (28; 2014 Jul 11; 289):19341-50. [Full Text/Abstract]
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 2014 Jul 3; 158 (158; 1; 2014 Jul 3):69-83. [Full Text/Abstract]
Brown RJ, Harris PM, Cox MG. Assessing the performance of standard methods to predict the standard uncertainty of air quality data having incomplete time coverage. Environ Sci Process Impacts. 2014 Jul; 16 (16; 7; 2014 Jul):1700-4. [Full Text/Abstract]
Troiano RP, McClain JJ, Brychta RJ, Chen KY. Evolution of accelerometer methods for physical activity research. Br J Sports Med. 2014 Jul; (2014 Jul). [Full Text/Abstract]
Martin KR, Koster A, Murphy RA, Van Domelen DR, Hung MY, Brychta RJ, Chen KY, Harris TB. Changes in Daily Activity Patterns with Age in U.S. Men and Women: National Health and Nutrition Examination Survey 2003-04 and 2005-06. J Am Geriatr Soc. 2014 Jul; 62 (7; 62; 2014 Jul):1263-71. [Full Text/Abstract]
van der Berg JD, Bosma H, Caserotti P, Eiriksdottir G, Arnardottir NY, Martin KR, Brychta RJ, Chen KY, Sveinsson T, Johannsson E, Launer LJ, Gudnason V, Jonsson PV, Stehouwer CD, Harris TB, Koster A. Midlife Determinants Associated with Sedentary Behavior in Old Age. Med Sci Sports Exerc. 2014 Jul; 46 (46; 7; 2014 Jul):1359-65. [Full Text/Abstract]
Guerrero AD, Dong MB, Zhao Y, Lau-Kilby A, Tarbell KV. Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors. Immunology. 2014 Jun 23; 143 (2014 Jun 23; 4; 143):640-50. [Full Text/Abstract]
Lee P, Smith S, Linderman J, Courville AB, Brychta RJ, Dieckmann W, Werner CD, Chen KY, Celi FS. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes. 2014 Jun 22; 63 (2014 Jun 22; 63; 11):3686-98. [Full Text/Abstract]
Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc Natl Acad Sci U S A. 2014 Jun 17; 111 (111; 2014 Jun 17; 24):8901-6. [Full Text/Abstract]
Kim YH, Kim KH, Szulejko JE, Bae MS, Brown RJ. Experimental validation of an effective carbon number-based approach for the gas chromatography-mass spectrometry quantification of 'compounds lacking authentic standards or surrogates. Anal Chim Acta. 2014 Jun 9; 830C (830C; 2014 Jun 9):32-41. [Full Text/Abstract]
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. Lipidomic Analyses of Female Mice Lacking Hepatic Lipase and Endothelial Lipase Indicate Selective Modulation of Plasma Lipid Species. Lipids. 2014 Jun; 49 (6; 49; 2014 Jun):505-15. [Full Text/Abstract]
Friend DM, Kravitz AV. Working together: basal ganglia pathways in action selection. Trends Neurosci. 2014 Jun; 37 (6; 37; 2014 Jun):301-3. [Full Text/Abstract]
Krull AC, Shearer JK, Gorden PJ, Cooper VL, Phillips GJ, Plummer PJ. Deep Sequencing Analysis Reveals the Temporal Microbiota Changes Associated with the Development of Bovine Digital Dermatitis. Infect Immun. [Full Text/Abstract]
Nayeri A, Upah NC, Sucu E, Sanz-Fernandez MV, Defrain JM, Gorden PJ, Baumgard LH. Effect of zinc amino acid complex-to-zinc sulfate ratio on the performance of Holstein cows. J Dairy Sci. [Full Text/Abstract]
Brown RJ, Webb WR, Goddard SL. Observation of a physical matrix effect during cold vapour generation measurement of mercury in emissions samples. Anal Chim Acta. 2014 May 1; 823 (2014 May 1; 823):20-4. [Full Text/Abstract]
Brown RJ, Mustoe CL. Demonstration of a standard dilution technique for standard addition calibration. Talanta. 2014 May; 122 (122; 2014 May):97-100. [Full Text/Abstract]
Basch E, Snyder C, McNiff K, Brown R, Maddux S, Smith ML, Atkinson TM, Howell D, Chiang A, Wood W, Levitan N, Wu AW, Krzyzanowska M. Patient-Reported Outcome Performance Measures in Oncology. J Oncol Pract. 2014 May; 10 (2014 May; 10; 3):209-11. [Full Text/Abstract]
Brown RJ, Yanovski JA. Estimation of insulin sensitivity in children: methods, measures and controversies. Pediatr Diabetes. 2014 May; 15 (2014 May; 15; 3):151-61. [Full Text/Abstract]
Borresen EC, Gundlach KA, Wdowik M, Rao S, Brown RJ, Ryan EP. Feasibility of Increased Navy Bean Powder Consumption for Primary and Secondary Colorectal Cancer Prevention. Curr Nutr Food Sci. 2014 May; 10 (2; 2014 May; 10):112-119. [Full Text/Abstract]
Cizza G, de Jonge L, Piaggi P, Mattingly M, Zhao X, Lucassen E, Rother KI, Sumner AE, Csako G. Neck circumference is a predictor of metabolic syndrome and obstructive sleep apnea in short-sleeping obese men and women. Metab Syndr Relat Disord. 2014 May; 12 (2014 May; 4; 12):231-41. [Full Text/Abstract]
Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P. Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy. Diabetes Care. 2014 Apr; 37 (37; 4; 2014 Apr):1101-7. [Full Text/Abstract]
Fox M, Ohlauson C, Sharpe AD, Brown RJ. The use of a Corophium volutator chronic sediment study to support the risk assessment of medetomidine for marine environments. Environ Toxicol Chem. 2014 Apr; 33 (33; 4; 2014 Apr):937-42. [Full Text/Abstract]
Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13; 507 (7491; 507; 2014 Mar 13):238-42. [Full Text/Abstract]
Lateef DM, Abreu-Vieira G, Xiao C, Reitman ML. Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3. Am J Physiol Endocrinol Metab. 2014 Mar; 306 (2014 Mar; 6; 306):E681-7. [Full Text/Abstract]
Sarkar G, Alattar M, Brown RJ, Quon MJ, Harlan DM, Rother KI. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes Care. 2014 Mar; 37 (2014 Mar; 37; 3):666-70. [Full Text/Abstract]
Nguyen TT, Jayadeva V, Cizza G, Brown RJ, Nandagopal R, Rodriguez LM, Rother KI. Challenging recruitment of youth with type 2 diabetes into clinical trials. J Adolesc Health. 2014 Mar; 54 (2014 Mar; 3; 54):247-54. [Full Text/Abstract]
Van Domelen DR, Caserotti P, Brychta RJ, Harris TB, Patel KV, Chen KY, Arnardottir NY, Eirikdottir G, Launer LJ, Gudnason V, Sveinsson T, Jóhannsson E, Koster A. Is there a sex difference in accelerometer counts during walking in older adults?. J Phys Act Health. 11 (3; 11):626-37. [Full Text/Abstract]
Demian WL, Jahouh FM, Stansbury D, Randell E, Brown RJ, Banoub JH. Characterizing changes in snow crab (Chionoecetes opilio) cryptocyanin protein during molting using matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry. Rapid Commun Mass Spectrom. 2014 Feb 28; 28 (2014 Feb 28; 28; 4):355-69. [Full Text/Abstract]
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 2014 Feb 4; 19 (19; 2; 2014 Feb 4):302-9. [Full Text/Abstract]
Brewer PJ, Brown RJ, Miller MN, Miñarro MD, Murugan A, Milton MJ, Rhoderick GC. Preparation and validation of fully synthetic standard gas mixtures with atmospheric isotopic composition for global CO2 and CH4 monitoring. Anal Chem. 2014 Feb 4; 86 (86; 3; 2014 Feb 4):1887-93. [Full Text/Abstract]
Zhang Z, Cypess AM, Miao Q, Ye H, Liew CW, Zhang Q, Xue R, Zhang S, Zuo C, Xu Z, Tang Q, Hu R, Guan Y, Li Y. The prevalence and predictors of active brown adipose tissue in Chinese adults. Eur J Endocrinol. 2014 Mar; 170 (2014 Mar; 170; 3):359-66. [Full Text/Abstract]
Fairclough G, Fox J, Mercer G, Reuber M, Brown RJ. Understanding the perceived treatment needs of patients with psychogenic nonepileptic seizures. Epilepsy Behav. 2014 Feb; 31 (2014 Feb; 31):295-303. [Full Text/Abstract]
Price JD, Beauchamp NM, Rahir G, Zhao Y, Rieger CC, Lau-Kilby AW, Tarbell KV. CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L. J Leukoc Biol. 2014 Feb; 95 (95; 2; 2014 Feb):325-36. [Full Text/Abstract]
Ravussin Y, Xiao C, Gavrilova O, Reitman ML. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One. 2014; 9 (2014; 9; 1):e85876. [Full Text/Abstract]
Brown RJ, Koutsoudakis G, Urbanowicz RA, Mirza D, Ginkel C, Riebesehl N, Calland N, Albecka A, Price L, Hudson N, Descamps V, Backx M, McClure CP, Duverlie G, Pecheur EI, Dubuisson J, Perez-del-Pulgar S, Forns X, Steinmann E, Tarr AW, Pietschmann T, Ball JK. Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution. J Virol. 2014 Jan; 88 (2014 Jan; 1; 88):667-78. [Full Text/Abstract]