U.S. Department of Health and Human Services

Diabetes, Endocrinology, and Obesity Branch

Marc L. Reitman, M.D., Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Brychta RJ, Arnardottir NY, Johannsson E, Wright EC, Eiriksdottir G, Gudnason V, Marinac CR, Davis M, Koster A, Caserotti P, Sveinsson T, Harris T, Chen KY. Influence of Day Length and Physical Activity on Sleep Patterns in Older Icelandic Men and Women. J Clin Sleep Med. 2015 Sep 14; (2015 Sep 14). [Full Text/Abstract]
Arnardottir NY, Koster A, Domelen DR, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Sigurdsson S, Johannsson E, Chen KY, Gudnason V, Harris TB, Launer LJ, Sveinsson T. Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Behav Brain Res. 2015 Sep 10; 296 (296; 2015 Sep 10):118-24. [Full Text/Abstract]
Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV 3rd, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metab. 2015 Sep 1; 22 (3; 22; 2015 Sep 1):427-36. [Full Text/Abstract]
Belcher BR, Berrigan D, Papachristopoulou A, Brady SM, Bernstein SB, Brychta RJ, Hattenbach JD, Tigner IL Jr, Courville AB, Drinkard BE, Smith KP, Rosing DR, Wolters PL, Chen KY, Yanovski JA. Effects of Interrupting Children's Sedentary Behaviors With Activity on Metabolic Function: A Randomized Trial. J Clin Endocrinol Metab. 2015 Aug 27; 100 (100; 10; 2015 Aug 27):3735-3743. [Full Text/Abstract]
Xiao C, Goldgof M, Gavrilova O, Reitman ML. Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C. Obesity (Silver Spring). 2015 Jun 5; 23 (2015 Jun 5; 23; 7):1450-1459. [Full Text/Abstract]
Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML. Integration of body temperature into the analysis of energy expenditure in the mouse. Mol Metab. 2015 Jun; 4 (6; 4; 2015 Jun):461-70. [Full Text/Abstract]
Tiano JP, Springer DA, Rane SG. SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. J Biol Chem. 2015 May 1; 290 (2015 May 1; 18; 290):11431. [Full Text/Abstract]
Sasai H, Brychta RJ, Wood RP, Rothney MP, Zhao X, Skarulis MC, Chen KY. Does Visceral Fat Estimated by Dual-Energy X-ray Absorptiometry Independently Predict Cardiometabolic Risks in Adults?. J Diabetes Sci Technol. 2015 Mar 23; 9 (2015 Mar 23; 4; 9):917-24. [Full Text/Abstract]
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC. RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals. J Clin Endocrinol Metab. 2015 Feb 12; 100 (100; 2015 Feb 12; 4):1639-1645. [Full Text/Abstract]
Cypess AM, Weiner LS, Roberts-Toler C, Franquet Elía E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015 Jan 6; 21 (2015 Jan 6; 21; 1):33-8. [Full Text/Abstract]
Fernandez P, Scaffidi P, Markert E, Lee JH, Rane S, Misteli T. Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. Cell Rep. 2014 Oct 1; 9 (2014 Oct 1; 9; 1):248-60. [Full Text/Abstract]
Irving WL, Rupp D, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ. Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res. 2014 Jul 22; 110 (110; 2014 Jul 22):52-9. [Full Text/Abstract]
Cypess AM, Haft CR, Laughlin MR, Hu HH. Brown fat in humans: consensus points and experimental guidelines. Cell Metab. 2014 Sep 2; 20 (20; 2014 Sep 2; 3):408-15. [Full Text/Abstract]
Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ. Lipid Regulation in Lipodystrophy Versus the Obesity-Associated Metabolic Syndrome: The Dissociation of HDL-C and Triglycerides. J Clin Endocrinol Metab. 2014 Jun 13; 99 (99; 2014 Jun 13; 9):E1676-80. [Full Text/Abstract]
Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes Cancer. 2014 Sep; 5 (9-10; 5; 2014 Sep):306-19. [Full Text/Abstract]
Srinivasa S, Wong K, Fitch KV, Wei J, Petrow E, Cypess AM, Torriani M, Grinspoon SK. Effects of lifestyle modification and metformin on irisin and FGF21 among HIV-infected subjects with the metabolic syndrome. Clin Endocrinol (Oxf). 2014 Aug 16; 82 (2014 Aug 16; 82; 5):678-85. [Full Text/Abstract]
Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5; 20 (20; 2014 Aug 5; 2):333-45. [Full Text/Abstract]
O'Connor MY, Thoreson CK, Ricks M, Courville AB, Thomas F, Yao J, Katzmarzyk PT, Sumner AE. Worse cardiometabolic health in African immigrant men than African American men: reconsideration of the healthy immigrant effect. Metab Syndr Relat Disord. 2014 Aug; 12 (6; 2014 Aug; 12):347-53. [Full Text/Abstract]
Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest. 2014 Aug 1; 124 (124; 8; 2014 Aug 1):3339-51. [Full Text/Abstract]
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30; 6 (6; 247; 2014 Jul 30):247ra103. [Full Text/Abstract]
Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality. J Biol Chem. 2014 Jul 11; 289 (28; 2014 Jul 11; 289):19341-50. [Full Text/Abstract]
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 2014 Jul 3; 158 (158; 1; 2014 Jul 3):69-83. [Full Text/Abstract]
Troiano RP, McClain JJ, Brychta RJ, Chen KY. Evolution of accelerometer methods for physical activity research. Br J Sports Med. 2014 Jul; (2014 Jul). [Full Text/Abstract]
Martin KR, Koster A, Murphy RA, Van Domelen DR, Hung MY, Brychta RJ, Chen KY, Harris TB. Changes in Daily Activity Patterns with Age in U.S. Men and Women: National Health and Nutrition Examination Survey 2003-04 and 2005-06. J Am Geriatr Soc. 2014 Jul; 62 (7; 62; 2014 Jul):1263-71. [Full Text/Abstract]
Guerrero AD, Dong MB, Zhao Y, Lau-Kilby A, Tarbell KV. Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors. Immunology. 2014 Jun 23; 143 (2014 Jun 23; 4; 143):640-50. [Full Text/Abstract]
Lee P, Smith S, Linderman J, Courville AB, Brychta RJ, Dieckmann W, Werner CD, Chen KY, Celi FS. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes. 2014 Jun 22; 63 (2014 Jun 22; 63; 11):3686-98. [Full Text/Abstract]
Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc Natl Acad Sci U S A. 2014 Jun 17; (2014 Jun 17). [Full Text/Abstract]
Friend DM, Kravitz AV. Working together: basal ganglia pathways in action selection. Trends Neurosci. 2014 Jun; 37 (6; 37; 2014 Jun):301-3. [Full Text/Abstract]
Krull AC, Shearer JK, Gorden PJ, Cooper VL, Phillips GJ, Plummer PJ. Deep Sequencing Analysis Reveals the Temporal Microbiota Changes Associated with the Development of Bovine Digital Dermatitis. Infect Immun. [Full Text/Abstract]
Nayeri A, Upah NC, Sucu E, Sanz-Fernandez MV, Defrain JM, Gorden PJ, Baumgard LH. Effect of zinc amino acid complex-to-zinc sulfate ratio on the performance of Holstein cows. J Dairy Sci. [Full Text/Abstract]
Brown RJ, Yanovski JA. Estimation of insulin sensitivity in children: methods, measures and controversies. Pediatr Diabetes. 2014 May; 15 (2014 May; 15; 3):151-61. [Full Text/Abstract]
Cizza G, de Jonge L, Piaggi P, Mattingly M, Zhao X, Lucassen E, Rother KI, Sumner AE, Csako G. Neck circumference is a predictor of metabolic syndrome and obstructive sleep apnea in short-sleeping obese men and women. Metab Syndr Relat Disord. 2014 May; 12 (2014 May; 4; 12):231-41. [Full Text/Abstract]
Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P. Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy. Diabetes Care. 2014 Apr; 37 (37; 4; 2014 Apr):1101-7. [Full Text/Abstract]
Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13; 507 (7491; 507; 2014 Mar 13):238-42. [Full Text/Abstract]
Lateef DM, Abreu-Vieira G, Xiao C, Reitman ML. Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3. Am J Physiol Endocrinol Metab. 2014 Mar; 306 (2014 Mar; 6; 306):E681-7. [Full Text/Abstract]
Sarkar G, Alattar M, Brown RJ, Quon MJ, Harlan DM, Rother KI. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes Care. 2014 Mar; 37 (2014 Mar; 37; 3):666-70. [Full Text/Abstract]
Nguyen TT, Jayadeva V, Cizza G, Brown RJ, Nandagopal R, Rodriguez LM, Rother KI. Challenging recruitment of youth with type 2 diabetes into clinical trials. J Adolesc Health. 2014 Mar; 54 (2014 Mar; 3; 54):247-54. [Full Text/Abstract]
Zhang Z, Cypess AM, Miao Q, Ye H, Liew CW, Zhang Q, Xue R, Zhang S, Zuo C, Xu Z, Tang Q, Hu R, Guan Y, Li Y. The prevalence and predictors of active brown adipose tissue in Chinese adults. Eur J Endocrinol. 2014 Mar; 170 (2014 Mar; 170; 3):359-66. [Full Text/Abstract]
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 2014 Feb 4; 19 (19; 2; 2014 Feb 4):302-9. [Full Text/Abstract]
Price JD, Beauchamp NM, Rahir G, Zhao Y, Rieger CC, Lau-Kilby AW, Tarbell KV. CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L. J Leukoc Biol. 2014 Feb; 95 (95; 2; 2014 Feb):325-36. [Full Text/Abstract]
Tracy DJ, Xu Z, Choi L, Acra S, Chen KY, Buchowski MS. Separating bedtime rest from activity using waist or wrist-worn accelerometers in youth. PLoS One. 2014; 9 (2014; 4; 9):e92512. [Full Text/Abstract]
Ravussin Y, Xiao C, Gavrilova O, Reitman ML. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One. 2014; 9 (2014; 9; 1):e85876. [Full Text/Abstract]
Carnie A, Lin J, Aicher B, Leon B, Courville AB, Sebring NG, de Jesus J, Dellavalle DM, Fitzpatrick BD, Zalos G, Powell-Wiley TM, Chen KY, Cannon RO 3rd. Randomized trial of nutrition education added to internet-based information and exercise at the work place for weight loss in a racially diverse population of overweight women. Nutr Diabetes. 2013 Dec 23; 3 (2013 Dec 23; 3):e98. [Full Text/Abstract]
Lee P, Linderman J, Smith S, Brychta RJ, Perron R, Idelson C, Werner CD, Chen KY, Celi FS. Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?. Osteoporos Int. 2013 Dec; 24 (2013 Dec; 12; 24):3053-7. [Full Text/Abstract]
Leon B, Jenkins S, Pepin K, Chaudhry H, Smith K, Zalos G, Miller BV 3rd, Chen KY, Remaley AT, Waclawiw MA, Sumner AE, Cannon RO 3rd. Insulin and extremity muscle mass in overweight and obese women. Int J Obes (Lond). 2013 Dec; 37 (2013 Dec; 37; 12):1560-4. [Full Text/Abstract]
Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, Dilorenzo TP. DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1. Int Immunol. 2013 Nov; 25 (25; 2013 Nov; 11):651-60. [Full Text/Abstract]
Muniyappa R, Warren MA, Zhao X, Aney SC, Courville AB, Chen KY, Brychta RJ, Germain-Lee EL, Weinstein LS, Skarulis MC. Reduced Insulin Sensitivity in Adults with Pseudohypoparathyroidism Type 1a. J Clin Endocrinol Metab. 2013 Nov; 98 (98; 2013 Nov; 11):E1796-801. [Full Text/Abstract]
Hall BE, Wankhade UD, Konkel JE, Cherukuri K, Nagineni CN, Flanders KC, Arany PR, Chen W, Rane SG, Kulkarni AB. TGF-β3 knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance. J Biol Chem. 2013 Nov 1; 288 (2013 Nov 1; 288; 44):32074-92. [Full Text/Abstract]
Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL 3rd, Kolodny GM. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nucl Med. 2013 Nov; 54 (2013 Nov; 54; 11):1896-901. [Full Text/Abstract]
Price JD, Linder G, Li WP, Zimmermann B, Rother KI, Malek R, Alattar M, Tarbell KV. Effects of Short-Term Sitagliptin Treatment on Immune Parameters in Healthy Individuals, A Randomized Placebo-Controlled Study. Clin Exp Immunol. 2013 Oct; 174 (2013 Oct; 174; 1):120-8. [Full Text/Abstract]