U.S. Department of Health and Human Services

Digestive Disease Branch

Stephen A. Wank, M.D., Chief


A selection of recent and significant publications can be viewed below.

Parrow NL, Leshin JA, Levine M. Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics.Antioxid Redox Signal. 2013 Apr 28 (2013 Apr 28) . [Full Text/Abstract]
Corpe CP, Eck P, Wang J, Al-Hasani H, Levine M. Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.J Biol Chem. 2013 Mar 29; 288 (288; 13; 2013 Mar 29) :9092-101. [Full Text/Abstract]
Di Florio A, Sancho V, Moreno P, Delle Fave G, Jensen RT. Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor.Biochim. Biophys. Acta. 2013 Mar; 1833 (2013 Mar; 1833; 3) :573-82. [Full Text/Abstract]
Welsh JL, Wagner BA, van't Erve TJ, Zehr PS, Berg DJ, Halfdanarson TR, Yee NS, Bodeker KL, Du J, Roberts LJ 2nd, Drisko J, Levine M, Buettner GR, Cullen JJ. Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.Cancer Chemother Pharmacol. 2013 Mar; 71 (2013 Mar; 71; 3) :765-75. [Full Text/Abstract]
Uehara H, Hocart SJ, González N, Mantey SA, Nakagawa T, Katsuno T, Coy DH, Jensen RT. The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members.Biochem. Pharmacol. 2012 Oct 1; 84 (7; 2012 Oct 1; 84) :936-48. [Full Text/Abstract]
Norton JA, Fraker DL, Alexander HR, Jensen RT. Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.Ann. Surg. 2012 Sep; 256 (2012 Sep; 256; 3) :509-17. [Full Text/Abstract]
Li H, Tu H, Wang Y, Levine M. Vitamin C in mouse and human red blood cells: an HPLC assay.Anal Biochem. 2012 Jul 15; 426 (2; 2012 Jul 15; 426) :109-17. [Full Text/Abstract]
Moody TW, Osefo N, Nuche-Berenguer B, Ridnour L, Wink D, Jensen RT. Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells.J. Pharmacol. Exp. Ther. 2012 Jun; 341 (2012 Jun; 341; 3) :873-81. [Full Text/Abstract]
Monti DA, Mitchell E, Bazzan AJ, Littman S, Zabrecky G, Yeo CJ, Pillai MV, Newberg AB, Deshmukh S, Levine M. Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer.PLoS One. 2012 Jan; 7 (7; 1; 2012 Jan) :e29794. [Full Text/Abstract]
Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, Levine M, Chen Q. Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer.Free Radic Biol Med. 2011 Jun 1; 50 (2011 Jun 1; 50; 11) :1610-9. [Full Text/Abstract]
Levine M, Padayatty SJ, Espey MG. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.Adv Nutr. 2011 Mar; 2 (2; 2011 Mar) :78-88. [Full Text/Abstract]
Kulke MH, Anthony LB, Bushnell DL, de Herder WW, Goldsmith SJ, Klimstra DS, Marx SJ, Pasieka JL, Pommier RF, Yao JC, Jensen RT, North American Neuroendocrine Tumor Society (NANETS). NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas.Pancreas. 2010 Aug; 39 (6; 39; 2010 Aug) :735-52. [Full Text/Abstract]
Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.PLoS One. 2010 Jul 7; 5 (2010 Jul 7; 7; 5) :e11414. [Full Text/Abstract]
Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.J Clin Invest. 2010 Apr; 120 (120; 4; 2010 Apr) :1069-83. [Full Text/Abstract]
González N, Nakagawa T, Mantey SA, Sancho V, Uehara H, Katsuno T, Jensen RT. Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor.J. Pharmacol. Exp. Ther. 2009 Oct; 331 (2009 Oct; 1; 331) :265-76. [Full Text/Abstract]
Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, Rousseau C, Robitaille L, Miller WH Jr. Phase I clinical trial of i.v. ascorbic acid in advanced malignancy.Ann Oncol. 2008 Nov; 19 (19; 2008 Nov; 11) :1969-74. [Full Text/Abstract]
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.Proc Natl Acad Sci U S A. 2008 Aug 12; 105 (105; 32; 2008 Aug 12) :11105-9. [Full Text/Abstract]
Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M. Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone.Am J Clin Nutr. 2007 Jul; 86 (86; 2007 Jul; 1) :145-9. [Full Text/Abstract]
Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.Proc Natl Acad Sci U S A. 2007 May 22; 104 (104; 21; 2007 May 22) :8749-54. [Full Text/Abstract]
Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M, Levine M. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.FASEB J. 2007 Feb; 21 (2; 21; 2007 Feb) :366-77. [Full Text/Abstract]
Hoffmann KM, Tapia JA, Berna MJ, Thill M, Braunschweig T, Mantey SA, Moody TW, Jensen RT. Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism.J. Biol. Chem. 2006 Dec 8; 281 (281; 2006 Dec 8; 49) :37705-19. [Full Text/Abstract]
Norton JA, Fraker DL, Alexander HR, Gibril F, Liewehr DJ, Venzon DJ, Jensen RT. Surgery increases survival in patients with gastrinoma.Ann. Surg. 2006 Sep; 244 (244; 2006 Sep; 3) :410-9. [Full Text/Abstract]
Moody TW, Sun LC, Mantey SA, Pradhan T, Mackey LV, Gonzales N, Fuselier JA, Coy DH, Jensen RT. In vitro and in vivo antitumor effects of cytotoxic camptothecin-bombesin conjugates are mediated by specific interaction with cellular bombesin receptors.J. Pharmacol. Exp. Ther. 2006 Sep; 318 (318; 2006 Sep; 3) :1265-72. [Full Text/Abstract]
Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.Proc Natl Acad Sci U S A. 2005 Sep 20; 102 (38; 2005 Sep 20; 102) :13604-9. [Full Text/Abstract]
Corpe CP, Lee JH, Kwon O, Eck P, Narayanan J, Kirk KL, Levine M. 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways.J Biol Chem. 2005 Feb 18; 280 (280; 7; 2005 Feb 18) :5211-20. [Full Text/Abstract]
Eck P, Erichsen HC, Taylor JG, Yeager M, Hughes AL, Levine M, Chanock S. Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2.Hum Genet. 2004 Sep; 115 (115; 4; 2004 Sep) :285-94. [Full Text/Abstract]
Mantey SA, Coy DH, Entsuah LK, Jensen RT. Development of bombesin analogs with conformationally restricted amino acid substitutions with enhanced selectivity for the orphan receptor human bombesin receptor subtype 3.J. Pharmacol. Exp. Ther. 2004 Sep; 310 (310; 3; 2004 Sep) :1161-70. [Full Text/Abstract]
Moody TW, Mantey SA, Pradhan TK, Schumann M, Nakagawa T, Martinez A, Fuselier J, Coy DH, Jensen RT. Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin receptor-containing tumor cells.J. Biol. Chem. 2004 May 28; 279 (2004 May 28; 279; 22) :23580-9. [Full Text/Abstract]
Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M. Vitamin C pharmacokinetics: implications for oral and intravenous use.Ann Intern Med. 2004 Apr 6; 140 (7; 140; 2004 Apr 6) :533-7. [Full Text/Abstract]
Tapia JA, García-Marin LJ, Jensen RT. Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells.J. Biol. Chem. 2003 Sep 12; 278 (278; 37; 2003 Sep 12) :35220-30. [Full Text/Abstract]