U.S. Department of Health and Human Services

Digestive Disease Branch

Stephen A. Wank, M.D., Chief

​Research Images

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Enteroendocrine cells in the organoidThe organoid was established from Nrg3-Cre x Rosa-tomato mouse. The cells producing red fluorescence were the cells that obtained endocrine cell fate following Nrg3 activation. Many endocrine cells were present in the multiple crypts surrounding the lumen-villi-like structure.Enlarge
Human adrenal glands secrete vitamin CAdrenal glands secrete vitamin C when stimulated by Adrenocorticotrophic hormone. Blood samples were obtained from both adrenals following adrenal venous catheterization. Enlarge
SVCT1 SNPs and predicted plasma vitamin C concentrationsPredicted (using a mathematical model) plasma vitamin C concentrations in subjects carrying single nucleotide polymorphisms (SNP) for the vitamin C transporter sodium vitamin C transporter 1 (SVCT1). Actual measured values for normal subjects are shown. Data on SVCT1 vitamin C transport was obtained from in vitro studies.Enlarge
Predicted plasma vitamin C concentrations following oral dosingPredicted (using a mathematical model) plasma vitamin C concentrations in normal subjects taking different doses of vitamin C until a steady state is reached. The mathematical model was constructed using dose concentration data in normal volunteers. Enlarge
Lovastatin induced apoptosis in prostate stromal cellsLovastatin (30 µmol/L) induced apoptosis in prostate stromal cells in culture. Cells were stained with acridine orange. Apoptotic cells (panels B and D) have small, bright, condensed, and fragmented nuclei with intact cell membranes. Enlarge
Octreotide increases exercise capacity in patients with acromegalyThe somatostatin analogue Octreotide increases exercise capacity in patients with acromegaly. Changes in exercise capacity [in metabolic equivalents (METS): 1 MET = energy expenditure at rest = O2 consumption of 3.5 ml. kg -1 body weight. min -1] and total exercise time at 0, 6, and 12 months are shown.Enlarge