U.S. Department of Health and Human Services

Digestive Disease Branch

Stephen A. Wank, M.D., Chief

​Research Images

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Enteroendocrine cells in the organoidThe organoid was established from Nrg3-Cre x Rosa-tomato mouse. The cells producing red fluorescence were the cells that obtained endocrine cell fate following Nrg3 activation. Many endocrine cells were present in the multiple crypts surrounding the lumen-villi-like structure.Enlarge
Human adrenal glands secrete vitamin CAdrenal glands secrete vitamin C when stimulated by Adrenocorticotrophic hormone. Blood samples were obtained from both adrenals following adrenal venous catheterization. Enlarge
SVCT1 SNPs and predicted plasma vitamin C concentrationsPredicted (using a mathematical model) plasma vitamin C concentrations in subjects carrying single nucleotide polymorphisms (SNP) for the vitamin C transporter sodium vitamin C transporter 1 (SVCT1). Actual measured values for normal subjects are shown. Data on SVCT1 vitamin C transport was obtained from in vitro studies.Enlarge
Predicted plasma vitamin C concentrations following oral dosingPredicted (using a mathematical model) plasma vitamin C concentrations in normal subjects taking different doses of vitamin C until a steady state is reached. The mathematical model was constructed using dose concentration data in normal volunteers. Enlarge
Lovastatin induced apoptosis in prostate stromal cellsLovastatin (30 µmol/L) induced apoptosis in prostate stromal cells in culture. Cells were stained with acridine orange. Apoptotic cells (panels B and D) have small, bright, condensed, and fragmented nuclei with intact cell membranes. Enlarge