U.S. Department of Health and Human Services

Kidney Diseases Branch

Jeffrey B. Kopp, M.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Kopp JB. Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder.Curr. Opin. Nephrol. Hypertens. 2013 Mar 10 (2013 Mar 10) . [Full Text/Abstract]
Chandra P, Kopp JB. Viruses and collapsing glomerulopathy: a brief critical review.Clin Kidney J. 2013 Feb; 6 (6; 2013 Feb; 1) :1-5. [Full Text/Abstract]
Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB, SK Investigators. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.Kidney Int. 2013 Jan; 83 (83; 1; 2013 Jan) :114-20. [Full Text/Abstract]
Zafrani L, Gerotziafas G, Byrnes C, Hu X, Perez J, Lévi C, Placier S, Letavernier E, Leelahavanichkul A, Haymann JP, Elalamy I, Miller JL, Star RA, Yuen PS, Baud L. Calpastatin controls polymicrobial sepsis by limiting procoagulant microparticle release.Am. J. Respir. Crit. Care Med. 2012 Apr 1; 185 (2012 Apr 1; 7; 185) :744-55. [Full Text/Abstract]
Leelahavanichkul A, Bocharov AV, Kurlander R, Baranova IN, Vishnyakova TG, Souza AC, Hu X, Doi K, Vaisman B, Amar M, Sviridov D, Chen Z, Remaley AT, Csako G, Patterson AP, Yuen PS, Star RA, Eggerman TL. Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice.J. Immunol. 2012 Mar 15; 188 (2012 Mar 15; 188; 6) :2749-58. [Full Text/Abstract]
Balow JE. Glomerular disease: perspectives on maintenance therapy in lupus nephritis.Nat Rev Nephrol. 2012 Feb 7; 8 (8; 2012 Feb 7; 3) :136-8. [Full Text/Abstract]
Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T. A missense mutation in PKD1 attenuates the severity of renal disease.Kidney Int. 2012 Feb; 81 (81; 2012 Feb; 4) :412-7. [Full Text/Abstract]
Leelahavanichkul A, Huang Y, Hu X, Zhou H, Tsuji T, Chen R, Kopp JB, Schnermann J, Yuen PS, Star RA. Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1.Kidney Int. 2011 Dec; 80 (80; 2011 Dec; 11) :1198-211. [Full Text/Abstract]
Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.J. Am. Soc. Nephrol. 2011 Nov; 22 (2011 Nov; 22; 11) :2129-37. [Full Text/Abstract]
Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.J. Neurosci. 2011 Aug 24; 31 (2011 Aug 24; 34; 31) :12241-50. [Full Text/Abstract]
Ferreira FM, Oliveira LC, Germino GG, Onuchic JN, Onuchic LF. Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain.Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 14; 108 (108; 2011 Jun 14; 24) :9833-8. [Full Text/Abstract]
Leelahavanichkul A, Yan Q, Hu X, Eisner C, Huang Y, Chen R, Mizel D, Zhou H, Wright EC, Kopp JB, Schnermann J, Yuen PS, Star RA. Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model.Kidney Int. 2010 Dec; 78 (2010 Dec; 78; 11) :1136-53. [Full Text/Abstract]
Boumpas DT, Bertsias GK, Balow JE. A decade of mycophenolate mofetil for lupus nephritis: is the glass half-empty or half-full?Ann. Rheum. Dis. 2010 Dec; 69 (69; 2010 Dec; 12) :2059-61. [Full Text/Abstract]
Watnick T, Germino GG. mTOR inhibitors in polycystic kidney disease.N. Engl. J. Med. 2010 Aug 26; 363 (2010 Aug 26; 363; 9) :879-81. [Full Text/Abstract]
Shillingford JM, Piontek KB, Germino GG, Weimbs T. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.J. Am. Soc. Nephrol. 2010 Mar; 21 (21; 3; 2010 Mar) :489-97. [Full Text/Abstract]
Illei GG, Shirota Y, Yarboro CH, Daruwalla J, Tackey E, Takada K, Fleisher T, Balow JE, Lipsky PE. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study.Arthritis Rheum. 2010 Feb; 62 (2; 2010 Feb; 62) :542-52. [Full Text/Abstract]
Doi K, Leelahavanichkul A, Yuen PS, Star RA. Animal models of sepsis and sepsis-induced kidney injury.J. Clin. Invest. 2009 Oct; 119 (2009 Oct; 119; 10) :2868-78. [Full Text/Abstract]
Marasà M, Kopp JB. Monoclonal antibodies for podocytopathies: rationale and clinical responses.Nat Rev Nephrol. 2009 Jun; 5 (6; 2009 Jun; 5) :337-48. [Full Text/Abstract]
Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG, Pandolfi PP, Boletta A. Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.Mol. Cell. Biol. 2009 May; 29 (9; 29; 2009 May) :2359-71. [Full Text/Abstract]
Austin HA 3rd, Illei GG, Braun MJ, Balow JE. Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy.J. Am. Soc. Nephrol. 2009 Apr; 20 (2009 Apr; 20; 4) :901-11. [Full Text/Abstract]
Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, McKenzie LM, Kajiyama H, Ahuja TS, Berns JS, Briggs W, Cho ME, Dart RA, Kimmel PL, Korbet SM, Michel DM, Mokrzycki MH, Schelling JR, Simon E, Trachtman H, Vlahov D, Winkler CA. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.Nat. Genet. 2008 Oct; 40 (40; 2008 Oct; 10) :1175-84. [Full Text/Abstract]
Doi K, Leelahavanichkul A, Hu X, Sidransky KL, Zhou H, Qin Y, Eisner C, Schnermann J, Yuen PS, Star RA. Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome.Kidney Int. 2008 Oct; 74 (74; 8; 2008 Oct) :1017-25. [Full Text/Abstract]
Zhou H, Cheruvanky A, Hu X, Matsumoto T, Hiramatsu N, Cho ME, Berger A, Leelahavanichkul A, Doi K, Chawla LS, Illei GG, Kopp JB, Balow JE, Austin HA 3rd, Yuen PS, Star RA. Urinary exosomal transcription factors, a new class of biomarkers for renal disease.Kidney Int. 2008 Sep; 74 (74; 5; 2008 Sep) :613-21. [Full Text/Abstract]
Zhou H, Cheruvanky A, Hu X, Matsumoto T, Hiramatsu N, Cho ME, Berger A, Leelahavanichkul A, Doi K, Chawla LS, Illei GG, Kopp JB, Balow JE, Austin HA 3rd, Yuen PS, Star RA. Urinary exosomal transcription factors, a new class of biomarkers for renal disease.Kidney Int. 2008 Sep; 74 (74; 5; 2008 Sep) :613-21. [Full Text/Abstract]
Petri M, Kasitanon N, Lee SS, Link K, Magder L, Bae SC, Hanly JG, Isenberg DA, Nived O, Sturfelt G, van Vollenhoven R, Wallace DJ, Alarcón GS, Adu D, Avila-Casado C, Bernatsky SR, Bruce IN, Clarke AE, Contreras G, Fine DM, Gladman DD, Gordon C, Kalunian KC, Madaio MP, Rovin BH, Sanchez-Guerrero J, Steinsson K, Aranow C, Balow JE, Buyon JP, Ginzler EM, Khamashta MA, Urowitz MB, Dooley MA, Merrill JT, Ramsey-Goldman R, Font J, Tumlin J, Stoll T, Zoma A, Systemic Lupus International Collaborating Clinics. Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index.Arthritis Rheum. 2008 Jun; 58 (6; 2008 Jun; 58) :1784-8. [Full Text/Abstract]
Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP, Kopp JB. Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy.Mol. Endocrinol. 2008 Feb; 22 (2; 22; 2008 Feb) :234-47. [Full Text/Abstract]
Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.Nat. Med. 2007 Dec; 13 (2007 Dec; 12; 13) :1490-5. [Full Text/Abstract]
Cho ME, Smith DC, Branton MH, Penzak SR, Kopp JB. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis.Clin J Am Soc Nephrol. 2007 Sep; 2 (2; 5; 2007 Sep) :906-13. [Full Text/Abstract]
Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.Hum. Mol. Genet. 2007 Aug 15; 16 (2007 Aug 15; 16) :1940-50. [Full Text/Abstract]
Kaimori JY, Nagasawa Y, Menezes LF, Garcia-Gonzalez MA, Deng J, Imai E, Onuchic LF, Guay-Woodford LM, Germino GG. Polyductin undergoes notch-like processing and regulated release from primary cilia.Hum. Mol. Genet. 2007 Apr 15; 16 (8; 16; 2007 Apr 15) :942-56. [Full Text/Abstract]