U.S. Department of Health and Human Services

Kidney Diseases Branch

Jeffrey B. Kopp, M.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP. Mutations in the Gene That Encodes the F-Actin Binding Protein Anillin Cause FSGS. J Am Soc Nephrol. 2014 Mar 27; 25 (9):1991-2002. [Full Text/Abstract]
Street JM, Yuen PS, Star RA. Bioactive Exosomes: Possibilities for Diagnosis and Management of Bladder Cancer. J Urol. 2014 Aug; 192 (2):297-8. [Full Text/Abstract]
Street JM, Souza AC, Alvarez-Prats A, Horino T, Hu X, Yuen PS, Star RA. Automated quantification of renal fibrosis with Sirius Red and polarization contrast microscopy. Physiol Rep. 2014 Jul 1; 2 (7). [Full Text/Abstract]
Wang W, Qiu L, Howard A, Solis N, Li C, Wang X, Kopp JB, Levi M. Protective effects of aliskiren and valsartan in mice with diabetic nephropathy. J Renin Angiotensin Aldosterone Syst. 2014 Jul 16. [Full Text/Abstract]
Chawla LS, Eggers PW, Star RA, Kimmel PL. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med. 2014 Jul 3; 371 (1):58-66. [Full Text/Abstract]
Fornoni A, Merscher S, Kopp JB. Lipid biology of the podocyte--new perspectives offer new opportunities. Nat Rev Nephrol. 2014 Jul; 10 (7):379-88. [Full Text/Abstract]
Starke C, Betz H, Hickmann L, Lachmann P, Neubauer B, Kopp JB, Sequeira-Lopez ML, Gomez RA, Hohenstein B, Todorov VT, Hugo CP. Renin Lineage Cells Repopulate the Glomerular Mesangium after Injury. J Am Soc Nephrol. 2014 Jun 5. [Full Text/Abstract]
Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A. 2014 May 20; 111 (20):E2130-9. [Full Text/Abstract]
Kansy K, Mueller AA, Mücke T, Kopp JB, Koersgen F, Wolff KD, Zeilhofer HF, Hölzle F, Pradel W, Schneider M, Kolk A, Smeets R, Acero J, Hoffmann J, DÖSAK Collaborative Group for Microsurgical Reconstruction. Microsurgical reconstruction of the head and neck - Current concepts of maxillofacial surgery in Europe. J Craniomaxillofac Surg. 2014 May 11. [Full Text/Abstract]
Dobrinskikh E, Okamura K, Kopp JB, Doctor RB, Blaine J. Human podocytes perform polarized, caveolae-dependent albumin endocytosis. Am J Physiol Renal Physiol. 2014 May 1; 306 (9):F941-51. [Full Text/Abstract]
Lee H, Abe Y, Lee I, Shrivastav S, Crusan AP, Hüttemann M, Hopfer U, Felder RA, Asico LD, Armando I, Jose PA, Kopp JB. Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney Int. 2014 Mar; 85 (3):561-9. [Full Text/Abstract]
Carson JM, Okamura K, Wakashin H, McFann K, Dobrinskikh E, Kopp JB, Blaine J. Podocytes Degrade Endocytosed Albumin Primarily in Lysosomes. PLoS One. 2014; 9 (6):e99771. [Full Text/Abstract]
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ, AASK Study Investigators, CRIC Study Investigators. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med. 2013 Dec 5; 369 (23):2183-96. [Full Text/Abstract]
Huynh N, Blain D, Glaser T, Doss EL, Zein WM, Lang DM, Baker EH, Hill S, Brewer CC, Kopp JB, Bardakjian TM, Maumenee IH, Bateman BJ, Brooks BP. Systemic diagnostic testing in patients with apparently isolated uveal coloboma. Am J Ophthalmol. 2013 Dec; 156 (6):1159-1168.e4. [Full Text/Abstract]
Wang L, Teng R, Di L, Rogers H, Wu H, Kopp JB, Noguchi CT. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes. 2013 Dec; 62 (12):4122-31. [Full Text/Abstract]
Kopp JB. JC viruria and kidney disease in APOL1 risk genotype individuals: is this a clue to a gene × environment interaction?. Kidney Int. 2013 Dec; 84 (6):1069-72. [Full Text/Abstract]
Kruszka PS, Manoli I, Sloan JL, Kopp JB, Venditti CP. Renal growth in isolated methylmalonic acidemia. Genet Med. 2013 Dec; 15 (12):990-6. [Full Text/Abstract]
Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013 Nov 27; 5 (213):213ra164. [Full Text/Abstract]
Abe Y, Sakairi T, Beeson C, Kopp JB. TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway. Am J Physiol Renal Physiol. 2013 Nov 15; 305 (10):F1477-90. [Full Text/Abstract]
Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013 Nov; 24 (11):1901-12. [Full Text/Abstract]
Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, de Vries U, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R. LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys. J Am Soc Nephrol. 2013 Nov; 24 (11):1830-48. [Full Text/Abstract]
Gasser DL, Winkler CA, Peng M, An P, McKenzie LA, Kirk GD, Shi Y, Xie LX, Marbois BN, Clarke CF, Kopp JB. Focal Segmental Glomerulosclerosis Is Associated With a PDSS2 Haplotype and Independently, With a Decreased Content of Coenzyme Q10. Am J Physiol Renal Physiol. 2013 Oct 15; 305 (8):F1228-38. [Full Text/Abstract]
Shrivastav S, Zhang L, Okamoto K, Lee H, Lagranha C, Abe Y, Balasubramanyam A, Lopaschuk GD, Kino T, Kopp JB. HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression and reduces PDC activity. Mol Endocrinol. 2013 Sep; 27 (9):1564-76. [Full Text/Abstract]
Bonventre JV, Basile D, Liu KD, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA, on behalf of the Kidney Research National Dialogue (KRND). AKI: A Path Forward. Clin J Am Soc Nephrol. 2013 Sep; 8 (9):1606-8. [Full Text/Abstract]
Zhou H, Kajiyama H, Tsuji T, Hu X, Leelahavanichkul A, Vento S, Frank R, Kopp JB, Trachtman H, Star RA, Yuen PS. Urinary exosomal Wilms tumor-1 as a potential biomarker for podocyte injury. Am J Physiol Renal Physiol. 2013 Aug 15; 305 (4):F553-9. [Full Text/Abstract]
Zhou H, Kajiyama H, Tsuji T, Hu X, Leelahavanichkul A, Vento S, Frank R, Kopp JB, Trachtman H, Star RA, Yuen PS. Urinary exosomal Wilms tumor-1 as a potential biomarker for podocyte injury. Am J Physiol Renal Physiol. 2013 Aug 15; 305 (4):F553-9. [Full Text/Abstract]
Barisoni L, Nast CC, Jennette JC, Hodgin JB, Herzenberg AM, Lemley KV, Conway CM, Kopp JB, Kretzler M, Lienczewski C, Avila-Casado C, Bagnasco S, Sethi S, Tomaszewski J, Gasim AH, Hewitt SM. Digital Pathology Evaluation in the Multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin J Am Soc Nephrol. 2013 Aug; 8 (8):1449-59. [Full Text/Abstract]
Kopp JB. An Expanding Universe of FSGS Genes and Phenotypes: LMX1B Mutations Cause Familial Autosomal Dominant FSGS Lacking Extrarenal Manifestations. J Am Soc Nephrol. 2013 Jul; 24 (8):1183-5. [Full Text/Abstract]
Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp JB, Yamamoto M, Noguchi CT. Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation. Int J Biochem Cell Biol. 2013 Jul; 45 (7):1155-64. [Full Text/Abstract]
Zhou H, Hasni SA, Perez P, Tandon M, Jang SI, Zheng C, Kopp JB, Austin H 3rd, Balow JE, Alevizos I, Illei GG. miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1. J Am Soc Nephrol. 2013 Jun; 24 (7):1073-87. [Full Text/Abstract]