U.S. Department of Health and Human Services

Kidney Diseases Branch

Jeffrey B. Kopp, M.D., Chief

​Research Images

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PCA trajectoriesThe principal component analysis of cDNA microarray data depicted demonstrates that global gene expression patterns are distinct for two different types of acute kidney injury. The trajectories reflect time-dependent divergence from the normal state.Enlarge
Telemetry blood pressureMiniaturized pressure transducers were catheterized into mouse carotid arteries, blood pressure was monitored in conscious, freely moving mice, and data was collected by radiotelemetry. Baseline mean arterial pressure was measured over several days, revealing diurnal variation. Mouse strains C57BL/6, 129S3, and CD-1 exhibit substantial differences in baseline blood pressure.Enlarge
Microparticles and fibrin deposition in sepsisCalpastatin-overexpressing transgenic mice, which are protected from sepsis-induced microparticle release and mortality, have restored susceptibility to fibrin deposition in liver and lung blood vessels when microparticles are reconstituted.Enlarge
Normal adult mouse kidneyTop: Normal adult mouse kidney stained with markers that distinguish proximal (green) and distal tubules (red). The image highlights the complex tubular structure of the kidney. (Cover, Nat Med Vol. 13, December 2007; Piontek et al, same issue 1490-1495). Bottom: Immunofluorescent image of a cystic mouse kidney stained for tubular markers.Enlarge
Human cystic kidneyA human cystic kidney removed from an individual with autosomal dominant polycystic kidney disease is depicted. For comparison, a normal adult kidney is approximately the size of a human fist.Enlarge