U.S. Department of Health and Human Services

Kidney Diseases Branch

Jeffrey B. Kopp, M.D., Chief

​Resources

Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

Resource Name Description
Pkd mutations and evaluation of same (U.S. Patent Number 20100047785 A1)

The present invention relates to methods of detecting novel mutations in a PKD1 and/or PKD2 gene that have been determined to be associated with autosomal dominant polycystic kidney disease (ADPKD) in order to detect or predict the occurrence of…

Podocin-rtTA (Tg(NPHS2-rtTA2*M2)1Jbk Mouse (Mutant Mouse: The tet transactivator (rtTA) gene placed under the control of the human NPHS2 gene).)

Reverse tetracycline-controlled transgenic mouse model (Tet-On) under the control of the specific promoter for the glomerular podocyte protein (Podocin, NPHS2).

Podocytes are post-mitotic epithelial cells that are positioned on the exterior aspect of…

Inducible podocyte-specific gene expression in transgenic mice (Podocin/rtTA DNA transgene)

The podocyte plays a key role in glomerular function and glomerular disease. To facilitate studies of podocyte function, we have developed a transgenic mouse model with inducible expression in the podocyte. The tetracycline-inducible transgenic…

Polycystic kidney disease gene (U.S. Patent Number 5,654,170)

The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1…

Polycystic kidney disease gene and protein (U.S. Patent Number 6,071,717)

The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1…

Polycystic kidney disease gene (Patent Number 6,867,288)

The present invention provides methods and compositions for treating cyst formation in PKD1-associated epithelial cells. Such methods encompass administering an isolated human PKD1 gene, or fragments of the gene, under conditions that result in…

Detection and treatment of polycystic kidney disease (U.S. Patent Number 7,553,644)

Compositions useful for examining the PKD1 gene are provided. In addition, methods for detecting mutations of the PKD1 gene, which can be associated with autosomal dominant polycystic kidney disease in humans, are provided. Methods for diagnosing a…

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Clinical Trials

Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.