Using chemical biology to develop new tools to interrogate cell surface proteins and their signaling

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Highly biased agonism for GPCR ligands via nanobody tethering.
Sachdev S, Creemer BA, Gardella TJ, Cheloha RW.
Nat Commun (2024 Jun 1) 15:4687. Abstract/Full Text
Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1.
Braga Emidio N, Cheloha RW.
Protein Sci (2024 Feb) 33:e4866. Abstract/Full Text
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Last Reviewed February 2024