U.S. Department of Health and Human Services
Funded Grants & Grant History

Funding Trends & Support of Core Values

NIDDK’s core values emphasize maintaining a strong investigator initiated R01 program, preserving a stable pool of talented new investigators, supporting key clinical studies and trials, and continuing strong support of training and career development programs, consistent with the vision of NIDDK Director, Dr. Griffin P. Rodgers (see Vision).

At NIDDK’s May 2012 Advisory Council meeting, NIDDK’s Deputy Director, Dr. Gregory Germino, highlighted these values and reviewed NIDDK’s resource focus on areas supporting the core values.

Following that presentation, the NIDDK generated additional data on application and funding trends to help our research community understand application and funding dynamics over recent years and demonstrate the NIDDK’s commitment to research and programs associated with the NIDDK’s core values and posted these data on the NIDDK website.  The NIDDK updates the charts on its website annually; the data shown here were recently updated to include Fiscal Year (FY) 2015.

NIDDK Funding Outcomes for Fiscal Year (FY) 2015 and Historical Application and Funding Trends

With the exception of Figure 8 (which includes initiative data), the data in all charts exclude initiatives (i.e., Requests for Applications), grants funded through the Special Statutory Funding Program for Type 1 Diabetes, and funds appropriated through the American Recovery and Reinvestment Act (ARRA).

Figure 1: Number of NIDDK competing R01 applications scoring within the top 50th percentile and number of NIDDK competing R01 applications funded in FY 2015

Plotting percentiles on the X axis and applications and awards on the Y axis 

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Note: "Applications" shown in the chart above include all applications that scored 50th percentile or better. Unscored applications, scored applications with no percentiles, and applications scoring above the 50th percentile are not shown (48 percent [n=1,332] of the applications received were unscored or scored above the 50th percentile). No unscored applications were funded in FY 2015.

The NIDDK nominal payline in FY 2015 was the 13th percentile for established investigators and the 18th percentile
for Early Stage Investigators (ESIs). The payline and additional programmatic scrutiny for R01 applications requesting more than $500,000 in direct costs are substantially more stringent. These data show that the NIDDK closely adheres to its payline, but does exercise some programmatic discretion to reach for a limited number of especially innovative or programmatically important applications.

Figure 2: NIDDK Competing R01 Application Funding Curves for FY 2006-2015

Plotting percentile bins on the X axis and percent of applications funded on the Y axis

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To generate the data for Figure 2, applications were placed into "percentile bins" as follows: Bin 1-5 includes all applications with percentile scores from 0.1 to 5.0, Bin 6-10 includes applications with percentile scores from 5.1 to 10.0, etc. Only applications that scored 50th percentile or better were included in the analysis.

The data demonstrate steep deflections in the percentage of applications funded at the nominal payline for each year. The R01 paylines for the years included in Figure 2 are shown in the table below.

Note: In FY 2012, the NIDDK began focusing on Early Stage Investigators (ESIs; see definition of and benefits conveyed to ESIs on the NIH “New and Early Stage Investigator Policies” webpage at http://grants.nih.gov/grants/new_investigators/index.htm), which is a subset of New Investigators (see also Figures 11 and 12).

Fiscal Year General Payline New Investigator Payline Early Stage Investigator (ESI) Payline ESI First Competitive Renewal Payline
2006 14 16 #### ####
2007 13 15 #### ####
2008 17 19 #### ####
2009 17 19 #### ####
2010 17 19 #### ####
2011 15 17 #### ####
2012 13 13 18 ####
2013 11 11 16 ####
2014 13 13 18 ####
2015 13 13 18 15

Figure 3: Cumulative Percentage of R01 Awards Across Percentiles (FY 2006 – 2015)

Plotting percentile bins on the X axis and percent of total number of funded R01/R37 grants on the Y axis  

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Only funded applications are considered in the data set charted in Figure 3. Percentile bin size equals one percentile and there is no overlap between bins. Percentiles with decimal places were summed into the next highest integral percentile as follows: 0.1-0.9 was summed into 1, 1.1-1.9 was summed into 2, etc. These cumulative funding data again demonstrate that the vast majority of applications funded by the NIDDK fall within the payline, but that the NIDDK does exercise some programmatic discretion to reach for a limited number of especially innovative or programmatically important applications.

Figure 4: Number of NIDDK R01 Grants (competing and noncompeting) Funded in FY 1997-2015

Plotting fiscal year on the X axis and number of R01 and R37 awards on the Y axis 

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Overall, the total number of R01 grants funded by the NIDDK has increased by slightly more than 20 percent since FY 1997. The major portion of this increase occurred during the years of the NIH budget doubling (FYs 1998-2003).  Over the past 5 years, there has been a slight decline in the number of grants funded. In the past, approximately half of the competing grants funded by the NIDDK were new (Type 1) awards, but since FY 2009 that proportion has risen to what is now well over half.

Figure 5: Number of competing NIDDK R01 applications (including revisions) received for funding consideration in FY 1998-2015 

Plotting fiscal year on the X axis and number of R01 applications on the Y axis  

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Figure 5 shows a substantial increase in the number of competing R01 applications received by the NIDDK between FYs 1998 and 2006.  After approximately 5 years of relatively flat growth prior to FY 2013, the number of applications increased in FYs 2013-2015.  Much of the observed increase between FY 1998 and FY 2006 and between FY 2013 and FY 2015 was largely due to new (Type 1) applications. Submission rates for competing renewal applications fluctuated somewhat between FY 1998 and FY 2014, but, overall, the numbers of renewal applications have remained relatively flat.  It should be noted that only one amendment and resubmission of an application was allowed after January 25, 2009. The full implementation of the NIH policy eliminating a second amended application is coincident with a rise in “New” competing R01 applications in FY 2010.

Figure 6: Overall NIDDK expenditures (includes direct and facilities and administrative costs) on R01 awards (competing and non-competing) in FY 1995-2015

Plotting fiscal year on the X axis and total awarded dollars on the Y axis 

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Figure 6 shows that NIDDK expenditures on R01 grants have increased markedly (147 percent) since FY 1995. This is because the NIDDK is funding a larger number of these awards (Figure 4) and also because the median cost of an R01 has increased substantially (Figure 7).

Figure 7: Median Total Costs (includes direct and facilities and administrative costs) of NIDDK R01 Grants (competing and non-competing) in FY 1995-2015

Plotting fiscal year on the X axis and median total costs on the Y axis 

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Figure 7 illustrates that the median cost of R01 awards has increased approximately 85 percent since FY 1995.  Since FY 2004, the number of grants receiving $500,000 or more in total costs has gone from 5 percent of the total number of awards to 19 percent of the total awarded R01s. The number of grants receiving $250,000 or less in total costs has declined from 20 percent of the total awards to 8 percent.

Figure 8: NIDDK Extramural research funding by category (Competing and Non-Competing)

Plotting percent of research funds by extramural research category on the X axis and fiscal year on the Y axis 

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Figure 8 shows that relative funding levels of most NIDDK extramural research categories have remained fairly stable since FY 2003.  These data were presented to the NIDDK’s Advisory Council in May 2012 in the context of the NIDDK’s core values. The NIDDK core values emphasize maintaining a strong investigator initiated R01 program, preserving a stable pool of talented new investigators, supporting key clinical studies and trials (support is generally represented in the Initiatives and Contracts categories), and continuing strong support of training and career development programs. Figures 9 to 12 illustrate other examples of how the NIDDK's portfolio has reflected NIDDK core values over time.

NIDDK Portfolio Categories:

  • R01 – Investigator Initiated (excludes R01s responding to NIDDK RFAs)
  • Other R – Includes other R activities (i.e., R03, R13, R15, R18, R21, R34, SBIR/STTR, etc), but excludes R24s and applications submitted to NIDDK RFAs
  • Initiatives – Awards made in response to NIDDK RFAs; includes most NIDDK large clinical trials and consortia.
  • Collaborative Grants – P01s and R24s that are not "mini-Centers"
  • Centers – Includes all non-P01 P awards and R24 "mini-Centers"
  • Career Development – Includes all Ks (including K99/R00)
  • Training – Includes all F and T activities
  • Other Research – Everything not captured in the categories above
  • Contracts and Interagency Agreements (IAAs)—Includes some large clinical studies

Figure 9: Maintaining a Stable Pool of NIDDK Investigators: Number of Investigators Supported by at Least one R01

Plotting fiscal year on the X axis and number of investigators on the Y axis 

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Figure 9 shows that the number of Principal Investigators (PIs) supported by at least one R01 remained relatively stable between FYs 2003 and 2009. In FYs 2010 and 2011, there were increases in the numbers of PIs supported with an NIDDK R01. It should be noted that in FY 2008 NIH, for the first time, began making multiple principal investigator R01 awards to support team science projects. The observed increases in numbers of PIs supported by the NIDDK in FYs 2010 and 2011 are largely attributable to multiple principal investigator R01 awards. The subsequent declines in FYs 2012-2015 are likely due in large part to paylines that became more stringent (i.e., after FY 2011) and inflationary pressures in the context of flat or declining budgets.

Figure 10: Preserving a Stable Pool of New Investigators: Number of NIDDK New Investigator R01 Applications and Awards

Plotting fiscal year on the X axis and number of applications or awards on the Y axis 

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Figure 10 shows that while application rates for New Investigators have remained fairly high, there was a deceleration in the number of New Investigator awards between FYs 2003 and 2006. Starting in FY 2007, the NIH and the NIDDK established new policies focused on New Investigators and these policies appear effective in mitigating downward pressures on New Investigator awards. The decrease in number of New Investigator awards in FY 2012 reflects a decrease in the number of applications from New Investigators that year. Numbers of New Investigator applications and awards recovered somewhat in FY 2013 through FY 2015, although in FY 2015 the number of New Investigator awards did not keep pace with increased numbers of applications and in fact there was a slight decline in the number of New Investigator awards. In addition, in FY 2012 NIH and NIDDK began focusing on Early Stage Investigators (ESIs; see definition of and benefits conveyed to ESIs on the NIH “New and Early Stage Investigator Policies” webpage at http://grants.nih.gov/grants/new_investigators/index.htm), which is a subset of New Investigators (see table associated with Figure 2 and Figures 11 and 12). It should be noted that the data in this chart count applications and awards, not persons.

Figure 11: Preserving a Stable Pool of New Investigators: Number of NIDDK Early Stage Investigator (ESI) R01 Applications and Awards

Plotting fiscal year on the X axis and number of ESI applications or awards on the Y axis

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Comparison of Figures 10 and 11 shows that while the subset of ESI applications fell in FY 2012 essentially in proportion to the total drop in New Investigator applications, the proportional drop in number of awards to ESIs was not as great. This is attributable in part to the NIDDK’s differential payline for ESI applications (see Figure 2 and the “NIDDK Policies Related to First-Time Investigator Support” at http://grants.nih.gov/grants/new_investigators/index.htm). The number of ESI awards in FY 2013 was essentially flat compared with the number of ESI awards in FY 2012, and the number of ESI awards in FY 2014 increased approximately 54 percent compared to FY 2013 ESI award numbers.  In FY 2015, the number of ESI awards dipped slightly compared to FY 2014; however the number of ESI awards in FY 2015 remains over 30 percent higher than the number in FY 2013.

Figure 12: Preserving a Stable Pool of New Investigators: Percent of New Investigator Applications and Awards that are ESI

Plotting fiscal year on the X axis and ESI applications/awards as a percentage on the Y axis 

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Figure 12 shows that the NIDDK’s differential payline for ESIs from FY 2012 to FY 2015 (see Figure 2 and the “NIDDK Policies Related to First-Time Investigator Support” at http://grants.nih.gov/grants/new_investigators/index.htm) has been effective in continuing to enhance ESI representation among New Investigator awards.

Figure 13: Support Pivotal Clinical Studies and Trials: NIDDK Human Subjects Research Funding as a Proportion of All Extramural Research Funding

Plotting fiscal year on the X axis and percentage of extramural research budget supporting human subjects research on the Y axis 

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Figure 13 demonstrates that the NIDDK commits a substantial proportion of its research funding to the support of clinical research involving human subjects. For the purpose of this analysis, we used the definition described in Kotchen et al, JAMA 2004 Feb; 291(7):836-43 and included all studies coded as using Human Subjects (HS+).

Figures 14A to 14D: The NIDDK Is Committed to Training the Next Generation

Figures 14A to 14D demonstrate that the NIDDK’s commitment to training and developing the careers of the next generation of scientists remains strong. Figure 14A shows that overall support of training and career development programs has increased since FY 2003 and that the slight deceleration of T awards support was offset by an increase in support of F awards (by design). Figures 14B and D illustrate that the numbers of NIDDK T awards and associated training slots have decreased somewhat since FY 2012 as the NIDDK enhanced support of F awards. Figure 14C shows that while the numbers of NIDDK K08 (Mentored Clinical Scientist Development Award) awards decreased between FYs 2003 and 2013, the numbers of K01 (Mentored Research Scientist Development Award) and K23 (Mentored Patient-Oriented Research Career Development Award) increased.  The NIDDK will continue to monitor carefully its training and career development programs to ensure appropriate balance.

Figure 14A. NIDDK Fellowship (F), Career Development (K), and Training (T) Awards as a Percent of Total Research Funding

Plotting fiscal year on the X axis and percent of total research funding by funding mechanism on the Y axis 

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Figure 14B. Number of NIDDK Fellowship (F), Career Development (K), and Training (T) Awards by Fiscal Year

Plotting fiscal year on the X axis and number of awards by funding mechanism on the Y axis 

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Figure 14C. Number of NIDDK Career Development (K) Awards by Activity and Fiscal Year

Plotting fiscal year on the X axis and number of awards by funding mechanism on the Y axis 

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Figure 14D. Number of NIDDK Training (T32) Award Slots by Fiscal Year

Plotting fiscal year on the X axis and number of T32 slots on the Y axis 

View enlarged Figure 14-D

Note: T32 awards made in FY 2015 continue into FY 2016.  The total numbers of T32 slots are reported at the end of the award period. Therefore, the FY 2015 information on T32 slots will not be available until later in FY 2016; thus, unlike the previous charts, FY 2015 data are not included here.​​​