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About Funding Mechanisms

NIH uses several types of grants to support research projects. Each has special characteristics, uses, and guidelines. 

Grant Mechanisms Commonly Used by NIDDK:​​​​​​​​​​​​​

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 Research Project - R01, P01, etc.

 

Research Project - R01, P01, etc.

Funding MechanismDescriptionMore Information
DP1 NIH Director's Pioneer Award
​Supports individual scientists of exceptional creativity, who propose pioneering – and possibly transforming approaches – to major challenges in biomedical and behavioral research.
NIH Mechanism Details
DP2 NIH Director's New Innovator Award
Supports highly innovative research projects by new investigators in all areas of biomedical and behavioral research.
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DP3 Type 1 Diabetes Targeted Research Award
​Supports research tackling major challenges in type 1 diabetes and promoting new approaches to these challenges by scientific teams.
NIDDK Mechanism Details
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DP5 Early Independence Award
Supports the independent research project of a recent doctoral degree recipient.
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P01 Program Project Grant
Supports a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme.
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R01 Research Project Grant
Support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.
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R13 Research Conference Grant
Supports recipient sponsored and directed international, national, or regional meetings, conferences, and workshops.
NIDDK Mechanism Details
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R15 Academic Research Enhancement Award (AREA)
Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists that have not been major recipients of NIH support.
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R18 Research Demonstration and Dissemination Project
Provides support designed to develop, test, and evaluate health service activities, and to foster the application of existing knowledge for the control of categorical diseases.
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R21 Exploratory/Developmental Grant
Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.
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R24 Resource-Related Research Project
Supports research projects that will enhance the capability of resources to serve biomedical research.
NIDDK Mechanism Details
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R25 Education Projects
Support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.
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R34 Clinical Trial Planning Grant
Supports the initial development of a clinical trial, including the establishment of the research team; the development of tools for data management and oversight; the development of a trial design and other essential elements of the study; and the collection of feasibility data.
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S06 Native American Research Centers for Health (NARCH)
Supports partnerships between American Indian/Alaska Native (AI/AN) tribes or tribally-based organizations and institutions that conduct intensive academic-level biomedical, behavioral and health services research.
NIDDK Mechanism Details
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SC1 Research Enhancement Award
Supports individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions to a stage where they can transition successfully to other extramural support (R01 or equivalent).
NIDDK Mechanism Details
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SC2 Pilot Research Project
Supports individual investigator-initiated pilot research projects for faculty at minority-serving institutions to generate preliminary data for a more ambitious research project.
NIDDK Mechanism Details
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U01 Research Project Cooperative Agreement
Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.
NIDDK Mechanism Details
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U13 Research Conference Cooperative Agreement
Supports international, national, or regional meetings, conferences, and workshops where substantial programmatic involvement is planned to assist the recipient.
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U34 Multi-center Clinical Study Cooperative Agreement
Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.
NIDDK Mechanism Details
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UC4 High Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding
Supports multi-year funded cooperative agreement research with high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery.
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X01 Resource Access Program
Invites eligible institutions to seek access to NIH research resources. This includes programs where institutions will request access to submit to the resource. It also includes programs where access to a NIH research resource is needed to conduct research.
NIH Mechanism Details

 

 Small Business - R41, R42, R43, R44

 

Small Business - R41, R42, R43, R44

Funding MechanismDescriptionMore Information
R41/R42 Small Business Technology Transfer Grant (STTR)
Supports cooperative R&D projects between small business concerns and research institutions to establish the technical merit and feasibility of ideas that have potential for commercialization. Awards are made to small business concerns only.
NIDDK Mechanism Details
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R43/R44 Small Business Innovation Research Grant (SBIR)
Supports projects to establish the technical merit and feasibility of R&D ideas which may ultimately lead to a commercial product(s) or service(s).
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 Training and Career Development - F, K, T, and Loan Repayment, etc.

 

Training and Career Development - F, K, T, and Loan Repayment, etc.

Funding MechanismDescriptionMore Information
F30 Individual Predoctoral National Research Service Award (NRSA) for M.D./Ph.D. Fellowship
Support for students enrolled in MD/PhD, or equivalent, combined degree programs once they have identified a dissertation project.
NIH Mechanism Details
F31 Individual Predoctoral National Research Service Award (NRSA)
Support for students enrolled in a doctoral degree program (usually PhD) once they have identified a mentor and have chosen a dissertation resesarch project.
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F32 Individual Postdoctoral National Research Service Award (NRSA)
Supports postdoctoral fellows to pursue mentored research training  prior to applying for a faculty position.  ​
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K01 Research Scientist Development Award
Supports basic scientists (non-clinicians) as they transition to independence and develop their careers with the support of a mentor.
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K08 Clinical Investigator Award
Supports early clinician scientists who are transitioning to independence in a junior faculty position while pursuing a basic or clinical research project and developing their career.
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K12 Physician Scientist Award
Award to an institution to support several individuals as they transition from fellowship to faculty while pursuing a research project with the help of a mentor(s). 
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K23 Mentored Patient-Oriented Research Career Development Award
Supports the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research.Supports early clinician scientists who are transitioning to independence in a junior faculty position and developing their career while pursuing a clinical research project that involves direct patient contact and the support of a mentor(s).
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K24 Midcareer Investigator Award in Patient-Oriented Research
Supports established clinician scientists to enable them to pursue their patient-oriented research while mentoring the next generation of patient-oriented researchers.
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K25 Mentored Quantitative Research Career Development Award
Supports highly productive postdoctoral fellows pursuing  mentored research projects while looking for faculty appointments. 
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K99/R00 Pathway to Independence Award
Supports the initial phase of a Career/Research Transition award program that provides 1-2 years of mentored support for highly motivated, advanced postdoctoral research scientists.
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L30 Loan Repayment Program for Clinical Researchers
NIH may repay up to $35,000 of your qualified student loan debt per year, including most undergraduate, graduate, and medical school loans if you are actively engaged in clinical research.
NIH Mechanism Details
L40 Loan Repayment Program for Pediatric Researchers
NIH may repay up to $35,000 of your qualified student loan debt per year, including most undergraduate, graduate, and medical school loans if you are actively engaged in research related to a pediatric disease or disease model.
NIH Mechanism Details
R03 Small Research Grant Program
Supports research projects that can be completed in a 2-yr time frame. NIDDK does not participate in the parent FOA for R03s, but issues FOAs for specific audiences, e.g. NIDDK- supported K01, K08, and K23 awardees.
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R03-Diversity Small Research Grant Program To Promote Diversty
Supports New Investigators from backgrounds nationally underrepresented in biomedical research to conduct small research projects in the scientific mission areas of the NIDDK.
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R25 Education Projects
Support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.
NIH Mechanism Details
S06 Native American Research Centers for Health (NARCH)
Supports partnerships between American Indian/Alaska Native (AI/AN) tribes or tribally-based organizations and institutions that conduct intensive academic-level biomedical, behavioral and health services research.
NIDDK Mechanism Details
NIH Mechanism Details
SC1 Research Enhancement Award
Supports individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions to a stage where they can transition successfully to other extramural support (R01 or equivalent).
NIDDK Mechanism Details
NIH Mechanism Details
SC2 Pilot Research Project
Supports individual investigator-initiated pilot research projects for faculty at minority-serving institutions to generate preliminary data for a more ambitious research project.
NIDDK Mechanism Details
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T32 Institutional National Research Service Award (NRSA)
Award to an institution to support several individuals, selected by the institution, in either short-term, predoctoral, and/or postdoctoral training positions with experienced mentors.  
NIDDK Mechanism Details
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T32 Diversity NRSA Diversity Supplement Award

Additional slot awarded to an existing training grant for either a specific medical student wishing to take a year off from school to pursue research training or for a pre- or post-doctoral trainee from a group underrepresented in biomedical research, when no slot is available on the training grant.​

NIDDK Mechanism Details
T32 MSRT Medical Student Research Training Supplement
Additional slot awarded to an existing training grant for either a specific medical student wishing to take a year off from school to pursue research training or for a pre- or post-doctoral trainee from a group underrepresented in biomedical research, when no slot is available on the training grant.
NIDDK Mechanism Details
T35 Short-Term National Research Service Award (NRSA)
Provides 2-3 months of support for medical students, selected by the institution, to pursue research training during off-quarters or summer periods.
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X01 Resource Access Program
Invites eligible institutions to seek access to NIH research resources. This includes programs where institutions will request access to submit to the resource. It also includes programs where access to a NIH research resource is needed to conduct research.
NIH Mechanism Details

 

 Centers - P20, P30, etc.

 

Centers - P20, P30, etc.

Funding MechanismDescriptionMore Information
P20 Center Exploratory Grant
Supports planning for new programs, modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of significance to the NIH.
NIH Mechanism Details
P30 Center Core Grant
Supports shared resources and facilities for categorical research by a number of investigators who provide a multidisciplinary approach to a joint research effort.
NIDDK Mechanism Details
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P50 Specialized Center Grant
Supports any part of the full range of research and development from very basic to clinical; may involve ancillary supporting activities such as protracted patient care necessary to the primary research or R&D effort.
NIDDK Mechanism Details
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S06 Native American Research Centers for Health (NARCH)
Supports partnerships between American Indian/Alaska Native (AI/AN) tribes or tribally-based organizations and institutions that conduct intensive academic-level biomedical, behavioral and health services research.
NIDDK Mechanism Details
NIH Mechanism Details
SC1 Research Enhancement Award
Supports individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions to a stage where they can transition successfully to other extramural support (R01 or equivalent).
NIDDK Mechanism Details
NIH Mechanism Details
SC2 Pilot Research Project
Supports individual investigator-initiated pilot research projects for faculty at minority-serving institutions to generate preliminary data for a more ambitious research project.
NIDDK Mechanism Details
NIH Mechanism Details
U54 Specialized Center Cooperative Agreement
Supports any part of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort.
NIH Mechanism Details
X01 Resource Access Program
Invites eligible institutions to seek access to NIH research resources. This includes programs where institutions will request access to submit to the resource. It also includes programs where access to a NIH research resource is needed to conduct research.
NIH Mechanism Details