Resource-Related Research Projects
NIDDK uses the R24 grant mechanism to support interdisciplinary research teams focused on innovative approaches to answer a single critically important research question or problem relevant to the mission of NIDDK. An R24 project is expected to support discovery or hypothesis-generating research or to develop unique resources or technologies that are needed to move a particular field forward.
Collectively, the team should bring together the necessary and appropriate expertise to answer one complex problem or challenge. Formation of the team of investigators should result in a greater contribution to meeting the challenge than would occur if each team member worked individually, and submission of a multi-PD/PI application is encouraged if it facilitates the team aspect of the approach. R24 grants can support basic, translational, or clinical science. Teams may also support integrated basic and clinical studies with the intent of accelerating translation of basic science to the clinic.
The NIDDK expects investigators forming collaborative teams to be funded and productive investigators who now wish to integrate their interests and efforts to facilitate a synergistic approach to the challenge not possible through other grant mechanisms. Support for resource development, generation, or utilization can be included to enhance the catalytic and transformative nature of the proposed studies. However, individual projects and cores are not allowed.
How to Apply
Applications are electronic (follow instructions in PAR-13-305). Consultation with NIDDK staff at least 3 months (and preferably 6 months) prior to the application due date is strongly encouraged.
Deadlines for Application
November 13, 2014; and November 17, 2015; by 5:00 PM local time of applicant organization.
Information from the NIH Office of Extramural Research
The R24 at the NIDDK
The team science approach encouraged by the NIDDK R24 could be used to generate a research resource (as in an NIH-defined R24), but may also include discovery-based or hypothesis-generating approaches with the goal to advance the relevant area of biomedical research relevant to the mission of the NIDDK.
Guidelines for Applicants
Frequently Asked Questions
How is the R24 different from other grant mechanisms, such as a multi-PI R01 or P01?
An R24 addresses a critical question or challenge relevant to the mission of NIDDK by taking either a discovery-based approach and/or generating a resource for the research community. Since an R24 is not driven by addressing a stated hypothesis, an R24 can be descriptive in nature. See table for comparison of the attributes of an R24, multi-PI R01 and P01.
Do the PIs have to show evidence of prior collaboration?
No, the PIs do not have to show evidence of prior collaboration. However, they must provide not only evidence that they are the appropriate team of investigators to address the problem at hand, but also evidence of a plan to work together effectively on the project. The applicants are given the opportunity to describe their working team structure in an attachment called “Team Science Justification and Organization”. Evidence that the team has worked together effectively will be reflected in a cohesive and convincing application. Finally, it is not necessarily a negative if some of the PIs have worked together previously on other collaborative efforts.
Does the application have to have preliminary data?
No, preliminary data is not required. However, the PIs need to convince the reviewers that they can address the problem at hand, with or without preliminary data provided. These projects are by their nature high risk, but the reviewers must have some confidence that the project might be successful. Providing this confidence may or may not require an integral piece of data.
To what extent should the project be new versus an extension of previous efforts?
The area being addressed by an R24 project should be seen as filling a gap in the field, taking a giant leap forward, not just the next logical step forward. An R24 should go in its own unique direction. NIDDK wants to use the R24 to build new science. This mechanism is not used to fund logical extensions of ongoing work.
What type of information should be included in a pre-approval request?
The following information will help staff in pre-approval consideration: 1) a description of the complex problem, including its significance and impact; 2) the specific aims of the project; 3) the importance and relevance to NIDDK; 4) the need for an R24 project, as opposed to another activity code; 5) biosketches for all key personnel; and 6) first year budget (indicate whether direct costs will exceed $1M in any year).