NIDDK follows all NIH policies
related to clinical and human subjects research. Additional information about NIDDK
clinical research programs, associated policies, and the
NIDDK Central Repository is provided below.
Most research involving human subjects at NIH is supported through Investigator-initiated Research
Project Grants (R01), NIH
Parent R01: PA-13-302.
NIDDK-Specific Funding Mechanisms for Clinical Research Studies
NIDDK invites investigator-initiated (R01) applications for ancillary studies to
certain ongoing large-scale clinical trials, epidemiological studies and disease
databases supported by the Institute.
Support for exploratory, short-term clinical studies that investigate new ideas
and novel approaches with less stringent requirements for preliminary data. The
short-term studies should focus on research questions that are likely to have high
clinical impact. Funding is provided is provided through a series of
disease-specific Funding Opportunity Announcements (FOAs).
Investigator-initiated Multi-center Clinical Studies (U34/U01)
These studies are supported through a two part grant process. First an implementation
planning grant (U34) is awarded followed by a cooperative agreement (U01) to conduct
the study. Potential applicants are encouraged to read the information provided
on the following pages before applying:
Most applicants will have had a U34 before applying for a U01. If you are seeking
an exemption from the U34 requirement, please read the information on
U01 Multi-center Clinical Studies.
Support for Use of NIDDK Central Repository Materials
The NIDDK invites investigators to apply for access to non-renewable samples from
the NIDDK Central Repositories. Information about available samples and current
funding opportunity announcements (FOAs) can be found at
NIDDK Clinical Research Policies
The following policies apply to all grantees conducting human subjects research.
Resources for Clinical Researchers
The NIDDK Central Repository
provides data and biosamples collected from current and previously funded NIDDK
NIDDK Research Centers provide core services and funding for pilot and feasibility
studies. View the individual centers pages below for more information and
contact information for NIDDK program directors.