U.S. Department of Health and Human Services

Ancillary Studies to Major Ongoing Clinical Studies

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites investigator-initiated (R01) research project applications under PAR-12-265 for ancillary studies to ongoing large-scale clinical trials, epidemiological studies and disease databases supported by the Institute, other Institutes and Centers of the National Institutes of Health, other government agencies or the private sector. These studies are generally focused on a wide range of diseases and conditions of direct interest to the NIDDK including diabetes, obesity, acute and chronic liver disease, chronic kidney disease, and benign prostatic hyperplasia, among others. The goal of these ancillary study proposals must be to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK. The proposed studies may require additional data or sample collection but may not interfere with the primary objectives of the main study. Each applicant must abide by the procedures for conducting ancillary studies established by the parent study.

Investigators interested in submitting an ancillary study grant application in response to this PAR are strongly advised to contact the appropriate initial NIDDK Program staff (see below) early in the process.

Inquiries should be directed as follows:

  • For studies related to digestive diseases and nutrition or obesity, contact Dr. Mary Horlick at (301) 594-4726 or by email.
  • For studies related to kidney and urologic diseases, contact Dr. John Kusek at (301) 594-7735 or by email.
  • For studies related to diabetes mellitus, contact Dr. Saul Malozowski at (301) 451-4683 or by email​.

Parent Study Examples

As examples, below is a list of the websites of NIDDK-sponsored, ongoing large-scale clinical research studies (“parent studies”) that are eligible for ancillary study grant applications under PAR-12-265. These websites provide information about ancillary studies to these parent studies.

Diabetes Studies

Digestive Disease and Nutrition Studies

Kidney, Urology and Hematology Studies

Obesity Studies

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