U.S. Department of Health and Human Services

Pre-Application Registration Requirements

Applicant organizations must complete and maintain the following registrations as described in the SBIR/STTR Application Guide SF 424 (R&R) to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

Dun and Bradstreet Universal Numbering System (DUNS)

All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin SAM, SBA Company Registry, and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.

System for Award Management (SAM) (formerly CCR)

The applicant must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

SBA Company Registry

New requirement.  In the Funding Opportunity Announcement, see Section IV. Application and Submission Information, “SF424(R&R) Other Project Information Component,” for instructions on how to register and how to attach proof of registration to your application package.  Applicants must have a DUNS number to complete this registration.  SBA Company registration is NOT required before SAM, Grants.gov or eRA Commons registration.

eRA Commons  

Applicants must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or Grants.gov registration. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.


Applicants must have an active DUNS number and SAM registration in order to complete the Grants.gov registration.


As always, if you have difficulties with the submission process, please contact the eRA Commons helpdesk:
Toll-free: 1-866-504-9552
Phone: 301-402-7469

TTY: 301-451-5939

Email: commons@od.nih.gov

Hours: Mon-Fri, 7 a.m. to 8 p.m. Eastern Time (Except for federal holidays)