U.S. Department of Health and Human Services

Clinical, Behavioral, and Epidemiological Obesity Research

The Clinical, Behavioral, and Epidemiological Obesity Research program supports clinical, behavioral, and epidemiological research focused on improved understanding of the development and modulation of obesity.

This research program includes clinical and behavioral studies in humans examining topics such as, but not limited to, identifying and understanding risk factors for the development and/or maintenance of excess weight gain, including basic behavioral, psychological, and social mechanisms and variation in dietary intake, dietary composition, meal frequency, eating patterns, sedentary behavior, and physical activity.  In addition, this program also supports research to understand metabolic effects and co-morbidities associated with obesity.  Studies across the lifespan, in various weight categories, and in high-risk populations are of interest.

The program supports the collection, analysis, and dissemination of data on obesity, weight status, weight control throughout the lifespan, and obesity-related disorders of public health significance, with particular emphasis on surveillance and follow-up studies.  Correlation and association analyses of risk factors for overweight/obesity—including environmental, psychological, social, economic—and secondary data analyses using data from a variety of sources, such as nationally representative, regional, or locally based data sets, are also supported.
Other relevant research projects would include methodologies to improve assessment of dietary intake and energy expenditure; i.e., sedentary behavior and physical activity, in humans.
The Clinical, Behavioral, and Epidemiological Obesity Research program does not support research to test nutrition or obesity prevention and treatment approaches.  For obesity prevention and treatment research, please see the Obesity Treatment and Prevention Program.  For clinical nutrition research, please see Clinical and Epidemiological Nutrition Research.

 NIDDK Staff

Mary Evans, Ph.D.Special Projects in Nutrition, Obesity, and Digestive Diseases; Lifestyle Interventions in Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
Mary Horlick, M.D.Clinical Bariatric Surgery; Pediatric Clinical Obesity ResearchChristine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes Translational Research
Padma Maruvada, Ph.D.Nutrient Metabolism; Clinical Obesity and NutritionAynur Unalp-Arida M.D., M.Sc., Ph.D.Epidemiology, Clinical Trials, Digestive Diseases, and Nutrition


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/20/2015Psychosocial and Behavioral Mechanisms in Bariatric Surgery (R01) (Summary) RFA-DK-16-017
11/19/2015Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44) (Summary) RFA-DK-16-004
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/3/2015Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01) (Summary) RFA-DK-16-014
11/3/2015Studies of HIV in Digestive Diseases Limited to Gastrointestinal Mucosal Immunology and Liver Diseases (R01) (Summary) RFA-DK-16-016
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction

The EPISOD study is a prospective, double-blind, randomized, sham-controlled, multi-center clinical trial. The EPISOD study enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi…

Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

Acute Liver Failure Study Group
The Acute Liver Failure Study Group is collecting biosamples and information on the natural history, causes and outcomes of Acute Liver Failure in the United States. In addition to the database, a clinical trial conducted to test whether the drug…
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…

View Additional Research Resources


 NIDDK Active Trials in Obesity

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​
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NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​