U.S. Department of Health and Human Services
Staff Search  

If you plan to apply, Register Early.

Registration is required at eRA Commons and grants.gov and can take 4 weeks.​

Metabolism, Energy Balance, and Obesity

The Metabolism, Energy Balance, and Obesity program supports basic and clinical studies related to energy balance and physiological mechanisms modulating weight gain, loss, and maintenance.  Specific areas of interest include factors that affect energy regulation such as food choices, diet composition, food intake, eating behavior, appetite, satiety, body composition, nutrient partitioning, sedentary behavior, and physical activity.  Other supported research topics include, but are not limited to, hormonal regulation of body composition, such as interactions between nutrition, exercise, and appetite-regulating hormones; circulating factors and their receptors involved in regulatory pathways controlling feeding behavior, satiety, and energy expenditure; interactions between the gut-brain axis and peripheral secretory metabolic signals (e.g., insulin, leptin, glucocorticoids, ghrelin, and other small bioactive peptides); integration of appetite-regulating  and metabolic signals in the regulation of food intake and energy balance; the impact of circadian rhythms on nutrient sensing and food intake; and the impact of gustatory signals on food consumption and energy balance.  Studies investigating the mechanism by which interventions, including drugs, devices, and surgery, affect food consumption or food preferences, physical activity, body composition, or other aspects of energy regulation are also supported by this program.
 
The program also supports investigator-initiated research on the biomedical and behavioral aspects of obesity and disordered eating behaviors, such as binge eating, in animal models.  Also of interest are studies that use improved methods to assess body composition, examine health-risk factors with specific degrees of obesity or body composition, and determine the effects of exercise on body composition.
 
This program also supports studies that explore mathematical models contributing to the understanding of whole-body energy balance and metabolism as well as the metabolic pathways in cells, tissues, and organs.  A particular focus of interest is on models that allow the integration of data gained from a variety of technical approaches, such as tracer studies, calorimetry, plasma hormone/cytokines, metabolomics, genomics, epigenomics, and proteomics, and on those models that would be of clinical utility, including prediction of plasma glucose levels in diabetes, nutritional partitioning, and weight management.
​​​​​​​​​
 

 NIDDK Staff

 
Christine Hunter, Ph.D., ABPPClinical research on behavioral treatments and prevention for obesity and diabetes; Centers for Diabetes Translational Research.James Hyde, Ph.D.Neurobiology of energy balance and body composition in obesity; diabetes centersMaren Laughlin, Ph.D.Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
Padma Maruvada, Ph.D.Nutrient Metabolism; Clinical Obesity and NutritionCorinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic diseaseSusan Z. Yanovski, M.D.Obesity and Eating Disorders

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
2/24/2014Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01) (Summary) PA-14-114
View More Funding Opportunities

 

 Research Resources

 
Resource NameDescription
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled … (Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Metabolic Disease

 
​View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.