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Nutrient Metabolism, Status, and Assessment

The Nutrient Metabolism, Status, and Assessment program supports basic and clinical studies related to the absorption, metabolism, bioavailability, and requirements of nutrients and other dietary components.  This includes research on processes at the organ, cellular, and subcellular levels in normal and diseased states.  Suitable studies include those that explore how the nutritional status of an organism, such as over-nutrition and under-nutrition, affects physiological and metabolic functions contributing to the pathophysiology of diseases of interest to the NIDDK.  Specific areas of interest include the role of gut-brain signals in nutrient sensing; mechanisms of action/interaction of nutrients within the body; the process of food digestion in the gastrointestinal tract; and the absorption and transport of water, ions, sugars, amino acids/peptides, lipids, vitamins, minerals, and other macromolecules and bioactive components.  Other supported studies include those that explore modifications of nutrient metabolism due to genetic variation, altered gut barrier function, and/or in response to stress, circadian and diurnal variations, drug use, toxicants, and physical activity in health and disease.  The program also supports studies that explore how dietary modifications affect gene regulation and expression at the transcriptional, translational, epigenetic, and functional level, including associated omic technologies.

Appropriate studies explore the impact of dietary modification on the human gut microbiome or of altered gut microbiome on nutrient absorption, gut barrier function, and permeability and metabolism.  Studies related to prebiotic and probiotic metabolism and associated microbiome changes and host physiology are also appropriate.

This program also supports studies that explore mathematical models contributing to the understanding of whole-body energy balance and metabolism, and of metabolic fluxes in cells, tissues, and organs.  A particular focus of interest is on models that allow the integration of data gained from a variety of technical approaches, such as tracer studies, calorimetry, plasma hormone/cytokines, metabolomics, genomics, epigenomics, and proteomics, and on those models that would be of clinical utility, including prediction of plasma glucose levels in diabetes, nutritional partitioning, nutritional status, and weight management.

The program supports research on specific metabolic considerations related to alternative forms of nutrient delivery and use, such as total parenteral nutrition.  Other supported studies involve research for improving methods to determine dietary intake and compliance, including dietary recall methodologies and questionnaires; novel approaches for collecting information on dietary intake; and the development of methods and assays for assessing nutritional status and for determining specific nutritional requirements in health and disease.


 NIDDK Staff

Mary Evans, Ph.D.Special Projects in Nutrition, Obesity, and Digestive Diseases; Lifestyle Interventions in Obesity; Nutrition Obesity Research CentersMichael J. Grey, Ph.D.Gastrointestinal Transport and Absorption; Gastrointestinal Host-Microbial Interactions; Basic Mucosal Immunology and Inflammation
Padma Maruvada, Ph.D.Nutrient Metabolism; Clinical Obesity and Nutrition


 Related Funding Opportunities

Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
2/12/2014Empirical Research on Ethical Issues Related to Central IRBs and Consent for Research Using Clinical Records and Data (R01) (Summary) RFA-OD-14-002
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 Research Resources

Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical … (Summary)

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)

View Additional Research Resources


 NIDDK Active Trials in Digestive Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.