U.S. Department of Health and Human Services

Clinical Research in Type 2 Diabetes

The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at understanding, preventing and treating type 2 diabetes (T2D). This program includes clinical trials that test pharmacologic, behavioral, surgical or practice-level approaches to the treatment and/or prevention of T2D, including promoting the preservation of beta cell function. Studies may also advance the development of new surrogate markers for use in clinical trials. Studies can be designed to understand the pathophysiology of T2D, including the role of gestational diabetes and metabolic imprinting on the development of T2D, as well as factors influencing the response to treatment. The program also encompasses epidemiologic studies that improve our understanding of the natural history and pathogenesis of T2D, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes, especially in the pediatric population. The program also supports research to test approaches to reduce racial/ethnic disparities in the incidence and/or clinical outcomes of T2D.​​​​​


 NIDDK Staff

Andrew Bremer, M.D., Ph.D.Basic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention and management of type 2 diabetes; gestational diabetes and maternal outcomes; and HIV and HIV-treatment associated metabolic/endocrine dysfunctionChristine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes Translational ResearchBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in youth and adults; human studies of the effect of the intrauterine environment on subsequent development of metabolic disease in offspring.
Peter J. Savage, M.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications.Karen L. Teff, Ph.D.Effects of bariatric surgery on diabetes and related metabolic outcomes; prevention, treatment and pathophysiology of hypoglycemia; effects of sleep/circadian as well as autonomic nervous system effects on diabetes-related metabolism in humans; clinical and basic research on intermediary hepatic metabolism


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/19/2015Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44) (Summary) RFA-DK-16-004
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
10/8/2015Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3) (Summary) RFA-DK-15-019
10/6/2015Diabetes Research Centers (P30) (Summary) RFA-DK-15-026
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

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 NIDDK Active Trials in Type 2 Diabetes

​View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​from the NIH's Center for Scientific Review.