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Clinical Research in Type 2 Diabetes

The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at the prevention and treatment of type 2 diabetes (T2D).  ​​​This program conducts clinical studies that advance the pharmacologic development of new drugs and surrogate markers for use in clinical trials that are designed to understand the pathophysiology of T2D—including the role of gestational diabetes and metabolic imprinting on the development of T2D—and to promote the preservation of beta cell function.  Also included are surgical treatments to prevent T2D in obese patients, medical and behavioral treatments to improve patient care and outcomes, epidemiologic studies, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes in the pediatric population.  The program supports research to define metabolic abnormalities and their natural history as well as studies that identify the basis for or test approaches to reduce racial/ethnic disparities in the incidence of T2D.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

 

 NIDDK Staff

 
Andrew BremerBasic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention of type 2 diabetes; HIV and HIV-treatment associated metabolic/endocrine dysfunction.Christine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes TranslationalBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in youth and adults; human studies of the effect of the intrauterine environment on subsequent development of metabolic disease in offspring.
Peter J. Savage, Ph.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionMyrlene Staten, M.D.Pharmacologic interventions and/or other medically related interventions to prevent or treat Type 2 Diabetes in adult patientsKaren L. Teff, Ph.D.Prevention, treatment and pathophysiology of hypoglycemia; gestational diabetes; and the effects of bariatric surgery on diabetes and related outcomes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
8/25/2014Identification of Novel Targets and Pathways Mediating Weight Loss, Diabetes Resolution and Related Metabolic Disease after Bariatric Surgery in Humans (R01) (Summary) RFA-DK-14-025
8/20/2014Limited Competition: Data Coordinating Center for Type 1 Diabetes TrialNet (UC4) (Summary) RFA-DK-14-507
8/15/2014Type 1 Diabetes TrialNet Clinical Centers (U01) (Summary) RFA-DK-14-016
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/29/2014NIDDK Clinician Scientist Mentoring Award to Promote Workforce Diversity (K05) (Summary) RFA-DK-14-005
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
(Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
(Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
(Summary)
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
(Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

(Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Type 2 Diabetes

 
​View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​from the NIH's Center for Scientific Review.