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Clinical Research in Type 2 Diabetes

The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at the prevention and treatment of type 2 diabetes (T2D).  ​​​This program conducts clinical studies that advance the pharmacologic development of new drugs and surrogate markers for use in clinical trials that are designed to understand the pathophysiology of T2D—including the role of gestational diabetes and metabolic imprinting on the development of T2D—and to promote the preservation of beta cell function.  Also included are surgical treatments to prevent T2D in obese patients, medical and behavioral treatments to improve patient care and outcomes, epidemiologic studies, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes in the pediatric population.  The program supports research to define metabolic abnormalities and their natural history as well as studies that identify the basis for or test approaches to reduce racial/ethnic disparities in the incidence of TD2.​​
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 NIDDK Staff

 
Andrew BremerBasic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention and treatment of type 2 diabetesChristine Hunter, Ph.D., ABPPClinical research on behavioral treatments and prevention for obesity and diabetes; Centers for Diabetes Translational Research.Barbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; glycemic reduction approaches and hypoglycemia during pregnancy; metabolic imprinting
Peter J. Savage, Ph.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionMyrlene Staten, M.D.Pharmacologic interventions and/or other medically related interventions to prevent or treat Type 2 Diabetes in adult patientsKaren L. Teff, Ph.D.Prevention, treatment and pathophysiology of hypoglycemia; gestational diabetes; and the effects of bariatric surgery on diabetes and related outcomes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/25/2014Limited Competition: Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4) (Summary) RFA-DK-14-505
6/19/2014Improving Diabetes Management in Young Children with Type 1 Diabetes (DP3) (Summary) RFA-DK-14-022
6/11/2014Research Using Subjects From Selected Type 1 Diabetes Clinical Studies (Living Biobank) (DP3) (Summary) PAR-14-258
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is … (Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
(Summary)
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program Outcomes Study is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of … (Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Type 2 Diabetes

 
​View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​from the NIH's Center for Scientific Review.