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Clinical Research in Type 2 Diabetes

The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at understanding, preventing and treating type 2 diabetes (T2D). This program includes clinical trials that test pharmacologic, behavioral, surgical or practice-level approaches to the treatment and/or prevention of T2D, including promoting the preservation of beta cell function. Studies may also advance the development of new surrogate markers for use in clinical trials. Studies can be designed to understand the pathophysiology of T2D—including the role of gestational diabetes and metabolic imprinting on the development of T2D.  The program also encompasses epidemiologic studies that improve our understanding of the natural history and pathogenesis of T2D, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes in the pediatric population. The program also supports research to test approaches to reduce racial/ethnic disparities in the incidence and/or clinical outcomes of T2D.​​​​​

 

 NIDDK Staff

 
Andrew Bremer, M.D., Ph.D.Basic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention of type 2 diabetes; HIV and HIV-treatment associated metabolic/endocrine dysfunction.Christine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes TranslationalBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in youth and adults; human studies of the effect of the intrauterine environment on subsequent development of metabolic disease in offspring.
Peter J. Savage, Ph.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications.Karen L. Teff, Ph.D.Prevention, treatment and pathophysiology of hypoglycemia; gestational diabetes; and the effects of bariatric surgery on diabetes and related outcomes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
9/30/2014Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4) (Summary) RFA-DK-14-508
9/24/2014Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) (Summary) RFA-DK-14-026
9/4/2014Advancing Interventions to Improve Medication Adherence (R01) (Summary) PA-14-334
8/27/2014Consortium on Beta-cell Death and Survival (HIRN-CBDS) (UC4) (Summary) RFA-DK-14-021
8/26/2014Type 1 Diabetes Complications IMPACT Award (DP3) (Summary) RFA-DK-14-017
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
(Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
(Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
(Summary)
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
(Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

(Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Type 2 Diabetes

 
​View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​from the NIH's Center for Scientific Review.