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Cystic Fibrosis Research and Translation Centers

The NIDDK-supported Cystic Fibrosis Research and Translation Centers are part of an integrated program of research support designed to enhance multidisciplinary research in pathogenesis and treatment of cystic fibrosis.  Centers provide increased, cost effective collaboration among multidisciplinary groups of investigators at institutions or a group of institutions with an established, comprehensive research base in cystic fibrosis.  The goal of these CF Research and Translation Centers is to support research to develop and test therapies for CF.  These Centers provide resources for communication and collaboration between basic and clinical researchers to study the multiple organ systems affect by CF.​​​​​​​​​​

 NIDDK Staff

Thomas Eggerman, M.D., Ph.D.Cystic fibrosis research and translation centers, clinical trials, and islet transplantation

Funding Mechanisms

NIDDK funds Cystic Fibrosis Centers under the P30 funding mechanism


Center Sites 

  • Case Western Reserve
  • University of Alabama at Birmingham
  • University of California San Francisco
  • University of Pittsburgh
  • University of Washington


 Related Funding Opportunities

Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
4/22/2014Predoctoral Training in Biomedical Big Data Science (T32) (Summary) RFA-HG-14-004
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.

 Research Resources

Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.


SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.


Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.


The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.


The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

View Additional Research Resources


 NIDDK Active Trials in Cystic Fibrosis

​View related clinical trials from ClinicalTrials.gov​.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.