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Cystic Fibrosis

The Cystic Fibrosis Research program supports both basic and clinical studies on the etiology, molecular pathogenesis, pathophysiology, diagnosis, and treatment of cystic fibrosis and its complications.  These studies examine the characterization of the cystic fibrosis gene, its mutations, and the molecular mechanisms by which mutations cause dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR) protein.  Also included are studies aimed at the elucidation of electrolyte transport pathways in affected epithelia, their relationship to the CFTR, and research on the potential roles of CFTR in the transport of molecules in critical cellular processes.  The ultimate goal of these mechanistic studies is to develop therapies that modulate the transport defect and improve the functioning of mutant CFTR.  Other research is conducted to determine the relationship between genotype and phenotype (e.g., variable clinical presentations and severity of disease) and to delineate the mechanisms underlying the disease’s characteristic inflammation and infection, with the ultimate goal of developing safe and effective methods of therapy for individuals with cystic fibrosis.​​​​​​​​​

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 NIDDK Staff

 
Thomas Eggerman, M.D., Ph.D.Cystic fibrosis research and translation centers, clinical trials, and islet transplantation

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
4/22/2014Predoctoral Training in Biomedical Big Data Science (T32) (Summary) RFA-HG-14-004
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

 

SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

 

Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

 

The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

 

The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Cystic Fibrosis

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.