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Cystic Fibrosis, CTFR

The Cystic Fibrosis Research program supports both basic and clinical studies on the etiology, molecular pathogenesis, pathophysiology, diagnosis, and treatment of cystic fibrosis and its complications.  These studies examine the characterization of the cystic fibrosis gene, its mutations, and the molecular mechanisms by which mutations cause dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR) protein.  Also included are studies aimed at the elucidation of electrolyte transport pathways in affected epithelia, their relationship to the CFTR, and research on the potential roles of CFTR in the transport of molecules in critical cellular processes.  The ultimate goal of these mechanistic studies is to develop therapies that modulate the transport defect and improve the functioning of mutant CFTR.  Other research is conducted to determine the relationship between genotype and phenotype (e.g., variable clinical presentations and severity of disease) and to delineate the mechanisms underlying the disease’s characteristic inflammation and infection, with the ultimate goal of developing safe and effective methods of therapy for individuals with cystic fibrosis.​​​​​​​​​

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 NIDDK Staff

 
Thomas Eggerman, M.D., Ph.D.Cystic fibrosis research and translation centers, clinical trials, and islet transplantation

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
10/29/2014Administrative Supplements for Human Islet Research(Admin Supp) (Summary) PA-15-025
10/20/2014Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01) (Summary) RFA-DK-14-023
9/24/2014Nuclear Organization and Function Interdisciplinary Consortium (NOFIC)(U54) (Summary) RFA-RM-14-006
9/24/2014Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) (Summary) RFA-DK-14-026
9/4/2014Advancing Interventions to Improve Medication Adherence (R01) (Summary) PA-14-334
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

NIDDK Repository for Biosamples and Data

Supports Data, Biosample, and Genetic Repositories to increase the impact of current and previously funded NIDDK studies by making their data and biospecimens available to the broader scientific community. These Repositories enable scientists not…

Epidemiology of Diabetes Interventions and Complications

An observational study examining the risk factors associated with the long-term complications of type 1 diabetes. The study began in 1994 and follows the 1441 participants previously enrolled in the Diabetes Control and Complications Trial (DCCT).

View Additional Research Resources

 

 NIDDK Active Trials in Cystic Fibrosis

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.