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Diabetes and Endocrine Disease Bioengineering, Biotechnology, and Imaging

The Diabetes and Endocrine Disease Bioengineering, Biotechnology, and Imaging​ program supports research on and development of new technologies for the diagnosis, monitoring, or treatment of diabetes and other endocrine and metabolic diseases.  Studies are aimed at developing:  technologies and resources to analyze and interpret protein structure; large networks of either metabolite pathways (metabolomics) or proteins (proteome); and resources and tools to address the many roles of cellular proteins in the physiology and pathophysiology of metabolic diseases, such as protein capture reagents, or 3D protein structure.  The program supports research addressing the development and implementation of glucose sensors as well as their combination with insulin delivery systems to form a ‘closed-loop’ artificial pancreas.  The program also promotes studies that focus on the development of in vivo molecular and functional imaging techniques to visualize and monitor physiological or metabolic processes and tissues (e.g., pancreatic beta cell mass, human brown adipose tissue).​​​​​​​​​​​​​​​​​​​​
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 NIDDK Staff

 
Guillermo A. Arreaza-Rubin, M.D.Diabetes and endocrine disease bioengineering and glucose sensingArthur L. Castle, Ph.D.Functional metabolomics and technology development to measure integrated metabolism in the etiology of metabolic disease
Maren Laughlin, Ph.D.Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic diseaseSalvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
4/22/2014Revisions to Add Biomedical Big Data Training to Active Institutional Training Grants (T32) (Summary) RFA-HG-14-005
3/21/2014Limited Competition: Continuation of the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study (U01) (Summary) RFA-DK-14-502
3/12/2014Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) (U01) (Summary) RFA-DK-14-501
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

 

SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

 

Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

 

The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

 

The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

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 NIDDK Active Trials in Diabetes and Endocrine Disease

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​