U.S. Department of Health and Human Services

Bioengineering, Biotechnology, and Imaging as applied to Diabetes, Metabolic and Endocrine Diseases

The bioengineering, biotechnology, and imaging programs support research on the development and application of technologies for the diagnosis, monitoring, and treatment of diabetes and other endocrine and metabolic diseases. Studies within these programs are aimed at: analyzing and interpreting protein structures that are relevant to metabolic and endocrine diseases; studying networks of metabolites (metabolome), proteins (proteome), and neural systems (connectome) that are relevant to metabolic and endocrine diseases; developing tools to address the many roles of metabolites, proteins, and neural systems in the physiology and pathophysiology of metabolic and endocrine diseases; addressing the development and implementation of glucose sensors as well as their combination with insulin delivery systems to form a ‘closed-loop’ artificial pancreas; developing and applying in vivo molecular and functional imaging techniques to visualize and monitor physiological or metabolic processes and tissues (e.g., pancreatic beta cell mass, human brown adipose tissue, neural systems).



 NIDDK Staff

Guillermo A. Arreaza-Rubín, M.D.Diabetes and endocrine disease bioengineering and glucose sensingArthur L. Castle, Ph.D.Functional metabolomics and technology development to measure integrated metabolism in the etiology of metabolic disease; fellowships and institutional training grants
Maren Laughlin, Ph.D.Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
Salvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to diabetes, metabolic, and endocrine diseasesLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications.


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/19/2015Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44) (Summary) RFA-DK-16-004
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/3/2015Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01) (Summary) RFA-DK-16-014
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
10/8/2015Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3) (Summary) RFA-DK-15-019
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources


 NIDDK Active Trials in Diabetes and Endocrine Disease

​View related clinical trials from ClinicalTrials.gov​.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​