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Diabetes and Endocrine Disease Bioengineering, Biotechnology, and Imaging

The Diabetes and Endocrine Disease Bioengineering, Biotechnology, and Imaging​ program supports research on and development of new technologies for the diagnosis, monitoring, or treatment of diabetes and other endocrine and metabolic diseases.  Studies are aimed at developing:  technologies and resources to analyze and interpret protein structure; large networks of either metabolite pathways (metabolomics) or proteins (proteome); and resources and tools to address the many roles of cellular proteins in the physiology and pathophysiology of metabolic diseases, such as protein capture reagents, or 3D protein structure.  The program supports research addressing the development and implementation of glucose sensors as well as their combination with insulin delivery systems to form a ‘closed-loop’ artificial pancreas.  The program also promotes studies that focus on the development of in vivo molecular and functional imaging techniques to visualize and monitor physiological or metabolic processes and tissues (e.g., pancreatic beta cell mass, human brown adipose tissue).​​​​​​​​​​​​​​​​​​​​

 NIDDK Staff

Guillermo A. Arreaza-Rubin, M.D.Diabetes and endocrine disease bioengineering and glucose sensingArthur L. Castle, Ph.D.Functional metabolomics and technology development to measure integrated metabolism in the etiology of metabolic disease; fellowships and institutional training grants
Maren Laughlin, Ph.D.Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic diseaseSalvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to metabolic disease


 Related Funding Opportunities

Posted DateTitleFull Announcement
7/21/2014Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (UC4) (Summary) RFA-DK-14-024
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.

 Research Resources

Resource NameDescription
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is … (Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program Outcomes Study is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of … (Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

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 NIDDK Active Trials in Diabetes and Endocrine Disease

​View related clinical trials from ClinicalTrials.gov​.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​