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Diabetes and Endocrine Disease Translational Research

The Diabetes and Endocrine Disease Translational Research program promotes studies that develop practical applications from basic science and lead to improvements in human health.  The program encourages efforts to translate proteomic, metabolomic, genomic, and epigenetic findings into clinical practice, to develop supporting technologies, and to translate discoveries into practical approaches to personalized medicine. Of scientific interest are studies that use genetic analyses to identify genes and epigenetic factors that influence variable responses to medications and the functional consequences of the pharmacodynamic and pharmacokinetic responses to therapeutic agents.  Systems biology approaches determine how higher-level properties of complex biological systems arise from the interactions among their parts—with an emphasis on studies that integrate data sets from genomics, transcriptomics, proteomics, and metabolomics to develop predictive models.  The program fosters interdisciplinary research aimed at a clearer understanding of the physiological and pathophysiological processes relevant to therapeutic development in diabetes and endocrine and metabolic disorders.  The program also encourages the development of high-throughput assays that researchers could use to screen molecular libraries for novel therapeutic agents and to discover new mechanisms of action for therapeutics.​​​​​​​​​​​​​


 NIDDK Staff

Aaron Pawlyk, Ph.D.​Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.
Salvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to metabolic disease


 Related Funding Opportunities

Posted DateTitleFull Announcement
8/15/2014Type 1 Diabetes TrialNet Clinical Centers (U01) (Summary) RFA-DK-14-016
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/29/2014NIDDK Clinician Scientist Mentoring Award to Promote Workforce Diversity (K05) (Summary) RFA-DK-14-005
7/21/2014Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (UC4) (Summary) RFA-DK-14-024
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.

 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…


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 NIDDK Active Trials in Diabetes and Endocrine Disease

​View related clinical trials from ClinicalTrials.gov​.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​ from the NIH's Center for Scientific Review.​