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Diabetes, Endocrine, and Metabolic Disease Translational Research

The Diabetes, Endocrine, and Metabolic Disease Translational Research program promotes studies to advance basic science towards practical applications leading to improvements in the diagnosis and treatment of diseases of interest to the Division of Diabetes, Endocrinology, & Metabolic Diseases at the NIDDK such as obesity, type 1 and type 2 diabetes and related aspects of endocrinology and metabolism, other metabolic disorders, and specific aspects of cystic fibrosis.  The program encourages efforts to develop the sound evidence base needed to advance proteomic, metabolomic, genomic, epigenomic, and other ‘omic findings towards applications to clinical studies, such as for precision medicine. Additionally, this program encompasses the development of the necessary supporting technologies to accomplish those goals. Studies that fall within this program may include: the identification of genes and epigenetic factors that influence variable pharmacodynamic and pharmacokinetic responses to therapeutic agents; systems biology approaches to determine how higher-level properties of complex biological systems arise from the interactions among their parts; interdisciplinary therapeutics discovery research to advance the validation of targets; and the identification of pre-therapeutic candidates through the development and implementation of drug discovery assays. Of particular interest to this program are models that are capable of predicting disease risk or therapeutic efficacy.
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 NIDDK Staff

 
Aaron Pawlyk, Ph.D.​Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.
Salvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to diabetes, metabolic, and endocrine diseases

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
10/17/2014Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC -CCs) (U01) (Summary) RFA-DK-14-027
10/17/2014Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Coordination and Data Management Center (CSCPDPC- CDMC) (U01) (Summary) RFA-DK-14-028
9/30/2014Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4) (Summary) RFA-DK-14-508
9/24/2014Nuclear Organization and Function Interdisciplinary Consortium (NOFIC)(U54) (Summary) RFA-RM-14-006
9/24/2014Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) (Summary) RFA-DK-14-026
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
(Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
(Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
(Summary)
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
(Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

(Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Diabetes and Endocrine Disease

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​ from the NIH's Center for Scientific Review.​