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Diabetes and Endocrine Disease Translational Research

The Diabetes and Endocrine Disease Translational Research program promotes studies that develop practical applications from basic science and lead to improvements in human health.  The program encourages efforts to translate proteomic, metabolomic, genomic, and epigenetic findings into clinical practice, to develop supporting technologies, and to translate discoveries into practical approaches to personalized medicine. Of scientific interest are studies that use genetic analyses to identify genes and epigenetic factors that influence variable responses to medications and the functional consequences of the pharmacodynamic and pharmacokinetic responses to therapeutic agents.  Systems biology approaches determine how higher-level properties of complex biological systems arise from the interactions among their parts—with an emphasis on studies that integrate data sets from genomics, transcriptomics, proteomics, and metabolomics to develop predictive models.  The program fosters interdisciplinary research aimed at a clearer understanding of the physiological and pathophysiological processes relevant to therapeutic development in diabetes and endocrine and metabolic disorders.  The program also encourages the development of high-throughput assays that researchers could use to screen molecular libraries for novel therapeutic agents and to discover new mechanisms of action for therapeutics.​​​​​​​​​​​​​

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 NIDDK Staff

 
Catherine McKeon, Ph.D.Cystic fibrosis research and translation centers; inborn errors of metabolism; and genetics of type 2 diabetesAaron Pawlyk, Ph.D.Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and personalized medicine in the treatment of diabetes
Salvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
2/12/2014Empirical Research on Ethical Issues Related to Central IRBs and Consent for Research Using Clinical Records and Data (R01) (Summary) RFA-OD-14-002
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 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

 

SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

 

Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

 

The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

 

The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

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 NIDDK Active Trials in Diabetes and Endocrine Disease

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​ from the NIH's Center for Scientific Review.​