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Diabetes and Endocrine Disease Translational Research

The Diabetes and Endocrine Disease Translational Research program promotes studies that develop practical applications from basic science and lead to improvements in human health.  The program encourages efforts to translate proteomic, metabolomic, genomic, and epigenetic findings into clinical practice, to develop supporting technologies, and to translate discoveries into practical approaches to personalized medicine. Of scientific interest are studies that use genetic analyses to identify genes and epigenetic factors that influence variable responses to medications and the functional consequences of the pharmacodynamic and pharmacokinetic responses to therapeutic agents.  Systems biology approaches determine how higher-level properties of complex biological systems arise from the interactions among their parts—with an emphasis on studies that integrate data sets from genomics, transcriptomics, proteomics, and metabolomics to develop predictive models.  The program fosters interdisciplinary research aimed at a clearer understanding of the physiological and pathophysiological processes relevant to therapeutic development in diabetes and endocrine and metabolic disorders.  The program also encourages the development of high-throughput assays that researchers could use to screen molecular libraries for novel therapeutic agents and to discover new mechanisms of action for therapeutics.​​​​​​​​​​​​​

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 NIDDK Staff

 
Aaron Pawlyk, Ph.D.​Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.
Salvatore Sechi, Ph.D.System biology of diabetes including development of predictive models; structural biology and proteomics as applied to metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/21/2014Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (UC4) (Summary) RFA-DK-14-024
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is … (Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
(Summary)
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program Outcomes Study is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of … (Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

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 NIDDK Active Trials in Diabetes and Endocrine Disease

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​ from the NIH's Center for Scientific Review.​