U.S. Department of Health and Human Services

Diabetes Genetics and Genomics

The Diabetes Genetics and Genomics program advances research to identify the genes and intergenic regions that predispose to or protect from developing type 1 or type 2 diabetes. In addition, research to define mechanisms underlying disease risk associated with genetic and genomic variation is also encouraged. By determining the genetic mechanisms underlying these diseases — and how genetic and epigenetic variation influence therapeutics — researchers should be able to develop better therapeutics and prevention strategies. Studies can involve the use of animal models to identify the genes responsible for development of or protection from the disease; research to develop genetic resources; creation of animal models for therapeutic trials; quantitative statistical and genetic methods to identify diabetes genes in human populations; investigation of the interactions of multiple genes and environmental factors; studies that determine genetic differences between populations that result in health disparities; and research to examine the genetics underlying variation in response to diabetes drugs.

 NIDDK Staff

Beena Akolkar, Ph.D.Clinical research in the prevention and immunopathogenesis of Type 1 Diabetes and the genetics and genomics of Type 1 and Type 2 Diabetes
Aaron Pawlyk, Ph.D.​Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/19/2015Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44) (Summary) RFA-DK-16-004
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
10/8/2015Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3) (Summary) RFA-DK-15-019
10/6/2015Diabetes Research Centers (P30) (Summary) RFA-DK-15-026
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources


 NIDDK Active Trials in Diabetes

View related clinical trials from ClinicalTrials.gov.​


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​