U.S. Department of Health and Human Services

Diabetes: Treatment, Prevention, and Complications

The Diabetes: Treatment, Prevention, and Complications Program supports both basic and clinical studies aimed at addressing the prevention, treatment and pathophysiology of type 1 and type 2 diabetes. Studies on drug development or testing of medical therapies to treat type 1 and type 2 diabetes are included in this program.  Studies specific to type 1 diabetes (T1DM) include those examining the cellular or immunological therapies to induce tolerance or arrest conversion from normal glucose homeostasis or dysglycemia to T1DM. Studies more specific to type 2 diabetes (T2DM) include those examining medical or surgical approaches that prevent diabetes, induce diabetes remission or improve dysglycemia. Studies relevant to both types of diabetes include those proposing lifestyle (diet and exercise) and other behavioral interventions to prevent or treat diabetes, such as approaches to improving health-related behaviors and enhancing diabetes self-management and other aspects of diabetes care.  This Program encompasses basic, clinical and translational research on the pathophysiology and treatment of diabetic complications that apply to multiple tissues and organ systems. It includes tissue-specific research on diabetic wound healing, diabetic neuropathy, and central nervous system impairments including cognition, brain structure and function, resulting from dysglycemia.  The program also includes research on diabetes complications such as hypoglycemia and diabetic ketoacidosis.
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 NIDDK Staff

 
Beena Akolkar, Ph.D.Clinical research in the prevention and immunopathogenesis of Type 1 Diabetes and the genetics and genomics of Type 1 and Type 2 DiabetesAndrew Bremer, M.D., Ph.D.Basic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention and management of type 2 diabetes; gestational diabetes and maternal outcomes; and HIV and HIV-treatment associated metabolic/endocrine dysfunctionCatherine Cowie, Ph.D., M.P.H.Epidemiology of diabetes, including development, control, interventions and complicationsChristine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes Translational Research
Barbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in youth and adults; human studies of the effect of the intrauterine environment on subsequent development of metabolic disease in offspring.Peter J. Savage, M.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications.Karen L. Teff, Ph.D.Effects of bariatric surgery on diabetes and related metabolic outcomes; prevention, treatment and pathophysiology of hypoglycemia; effects of sleep on diabetes in humans

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/29/2015Type 1 Diabetes Pathfinder Award (DP2) (Summary) RFA-DK-15-030
7/28/2015Small Business Innovation Research (SBIR) to Develop New Methods and Technologies for Assessment of Risk and for Early Diagnosis and Prognosis of Type 1 Diabetes (T1D) (R43/R44) (Summary) RFA-DK-15-024
7/24/2015Small Business Innovation Research (SBIR) to Develop New or Improved Closed Loop Automated Technologies for Diabetes Therapy and Monitoring (R43/R44) (Summary) RFA-DK-15-022
7/17/2015Mouse Metabolic Phenotyping Centers Consortium (U2C) (Summary) RFA-DK-15-010
7/7/2015Mechanisms Underlying the Contribution of Type 1 Diabetes Risk Associated Variants (DP3) (Summary) RFA-DK-15-025
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources

 

 NIDDK Active Trials in Diabetes

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​