The Diabetes: Treatment, Prevention, and Complications Program supports both basic and clinical studies aimed at addressing the prevention, treatment, and pathophysiology of hypoglycemia and diabetes. Studies include lifestyle and other behavioral interventions to prevent or treat diabetes, such as approaches to improving health-related behaviors and to enhancing diabetes self-management and other aspects of diabetes care. The Program examines the role of diet and exercise in the prevention and treatment of diabetes, as well as the outcomes of bariatric surgery as they relate to improved glycemia and remission of type 2 diabetes. In the area of prevention of type 1 diabetes, research interests include studies on drug development and cellular therapy designed to prevent impaired glucose tolerance (IGT), arrest conversion of IGT to type 1 diabetes, enhance peripheral glucose metabolism or reduce hepatic glucose production, and increase insulin sensitivity. This Program also encompasses basic and clinical research related to acute and chronic complications of type 1 and type 2 diabetes, such as the effects on the vascular and organ systems, as well as clinical studies that develop and evaluate strategies to prevent or treat these complications.