The Diabetic Kidney Disease program advances basic research, natural history studies, and clinical trials. Fundamental research addresses the molecular pathogenesis of extracellular matrix expansion and glomerulosclerosis. Also of interest are studies on the role of the renin-angiotensin system, growth factors, and cell signaling pathways. The portfolio aims to prevent, reverse, and ameliorate fibrosis. Specific projects include studies that investigate the mechanisms of fibrosis and use of noninvasive imaging techniques to assess fibrosis. Other work seeks to discover genes that protect people from or predispose them to diabetic nephropathy and identify early markers of increased risk for this disease.