U.S. Department of Health and Human Services

Diabetic Kidney Disease

The Diabetic Kidney Disease program advances basic research, natural history studies, and clinical trials.  Fundamental research addresses the molecular pathogenesis of extracellular matrix expansion and glomerulosclerosis.  Also of interest are studies on the role of the renin-angiotensin system, growth factors, and cell signaling pathways.  The portfolio aims to prevent, reverse, and ameliorate fibrosis.  Specific projects include studies that investigate the mechanisms of fibrosis and use of noninvasive imaging techniques to assess fibrosis.  Other work seeks to discover genes that protect people from or predispose them to diabetic nephropathy and identify early markers of increased risk for this disease.​​​​​​​​​


 NIDDK Staff

Michael Flessner, M.D., Ph.D.Clinical CKD; Glomerular Disease; Clinical PKD; PKD CentersDeborah Hoshizaki, Ph.D.Kidney and Urogenital Development; Kidney and Urology Regeneration and Repair; Urology Centers
Chris Ketchum, Ph.D.Deputy Director, KUH Basic Science; Renal PhysiologyKrystyna Rys-Sikora, Ph.D.Basic AKI and CKD


 Related Funding Opportunities

Posted DateTitleFull Announcement
9/24/2015Impact of the Use of Glucose Monitoring and Control Technologies on Health Outcomes and Quality of Life in Older Adults with Type 1 Diabetes (T1D) (DP3) (Summary) RFA-DK-15-028
8/7/2015Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) (Summary) PA-15-321
8/4/2015Understanding the Pathogenesis and Etiology of Type 1 Diabetes Using Biosamples and Subjects from Clinical Studies (DP3) (Summary) RFA-DK-15-018
7/29/2015Type 1 Diabetes Pathfinder Award (DP2) (Summary) RFA-DK-15-030
7/28/2015Small Business Innovation Research (SBIR) to Develop New Methods and Technologies for Assessment of Risk and for Early Diagnosis and Prognosis of Type 1 Diabetes (T1D) (R43/R44) (Summary) RFA-DK-15-024
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

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 NIDDK Active Trials in Diabetes

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.