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Digestive Diseases Clinical Research and Epidemiology

The Digestive Diseases Clinical Research and Epidemiology program supports patient-oriented clinical research and epidemiology research in digestive diseases.  The program supports small clinical studies focused on research that is innovative and of potential high impact and should lead to full-scale clinical trials.  The program encourages Phase III clinical trials, which are typically multi-center and involve several hundred patients randomized to two or more treatments, one of which is usually a placebo.  The aim of such trials is to provide evidence for support of, or a change in, health policy or standard of care.  Studied treatments may include pharmacologic, nonpharmacologic, and behavioral interventions for disease prevention, prophylaxis, diagnosis, or therapy.  The program’s research portfolio includes studies on:  Helicobacter pylori; inflammatory bowel disease; functional bowel disorders and constipation; nonulcer dyspepsia; celiac disease; intestinal failure; short gut syndrome; and small bowel transplantation.
This program also serves as a focal point for the collection, analysis, and dissemination of data on digestive diseases and their complications.  The program encourages research that addresses risk factors for disease occurrence and disease prognosis or natural history.  The program also supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.  Specific areas of focus for this program include:  identifying the data needed to address the scientific and public health issues in digestive diseases and nutrition; addressing the epidemiology of digestive diseases and nutritional disorders of public health significance, with particular emphasis on national surveys and their follow-up; promoting the timely availability of reliable data to pertinent scientific, medical, and public organizations; standardizing data collection and terminology in clinical and epidemiological research; and working closely with members of the scientific community to develop investigator-initiated research in digestive diseases and nutrition epidemiology.

 NIDDK Staff

Dana K. Andersen, M.D.Observational and Investigational Clinical Research; Biomedical Devices, Surgical Interventions, and MedicationsFrank Hamilton, M.D., M.P.H.Gastrointestinal and Nutrition AIDS; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
Jose Serrano, M.D., Ph.D.Liver Bioengineering and Biotechnology; Cell and Molecular Biology of the Liver; Developmental Biology and Regeneration; Drug-induced Liver Disease; Gastrointestinal Neuroendocrinology; Exocrine Pancreas; PancreatitisAynur Unalp-Arida M.D., M.Sc., Ph.D.Epidemiology, Clinical Trials, Digestive Diseases, and Nutrition


 Related Funding Opportunities

Posted DateTitleFull Announcement
3/9/2015Advancing Mechanistic Probiotic/Prebiotic and Human Microbiome Research (R01) (Summary) PA-15-135
2/24/2015Administrative Supplements for Common Basic Sociobehavioral Mechanisms and Processes that Facilitate or Impede Self-Management of Chronic Conditions (Admin Supp) (Summary) PA-15-122
1/12/2015NIH Big Data to Knowledge (BD2K) Enhancing Diversity in Biomedical Data Science (R25) (Summary) RFA-MD-15-005
1/8/2015NIH Pathway to Independence Award (Parent K99/R00) (Summary) PA-15-083
12/11/2014NIDDK Multi-Center Clinical Study Cooperative Agreement (U01) (Summary) PAR-15-067
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Predicting Response to Standardized Pediatric Colitis Therapy

The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

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 NIDDK Active Trials in Digestive Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.