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Digestive Diseases Clinical Research and Epidemiology

The Digestive Diseases Clinical Research and Epidemiology program supports patient-oriented clinical research and epidemiology research in digestive diseases.  The program supports small clinical studies focused on research that is innovative and of potential high impact and should lead to full-scale clinical trials.  The program encourages Phase III clinical trials, which are typically multi-center and involve several hundred patients randomized to two or more treatments, one of which is usually a placebo.  The aim of such trials is to provide evidence for support of, or a change in, health policy or standard of care.  Studied treatments may include pharmacologic, nonpharmacologic, and behavioral interventions for disease prevention, prophylaxis, diagnosis, or therapy.  The program’s research portfolio includes studies on:  Helicobacter pylori; inflammatory bowel disease; functional bowel disorders and constipation; nonulcer dyspepsia; celiac disease; intestinal failure; short gut syndrome; and small bowel transplantation.
 
This program also serves as a focal point for the collection, analysis, and dissemination of data on digestive diseases and their complications.  The program encourages research that addresses risk factors for disease occurrence and disease prognosis or natural history.  The program also supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.  Specific areas of focus for this program include:  identifying the data needed to address the scientific and public health issues in digestive diseases and nutrition; addressing the epidemiology of digestive diseases and nutritional disorders of public health significance, with particular emphasis on national surveys and their follow-up; promoting the timely availability of reliable data to pertinent scientific, medical, and public organizations; standardizing data collection and terminology in clinical and epidemiological research; and working closely with members of the scientific community to develop investigator-initiated research in digestive diseases and nutrition epidemiology.
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 NIDDK Staff

 
Dana K. Andersen, M.D.Observational and Investigational Clinical Research; Biomedical Devices, Surgical Interventions, and MedicationsFrank Hamilton, Ph.D., M.P.H.Gastrointestinal and Nutrition AIDS; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
Jose Serrano, M.D., Ph.D.Liver Bioengineering and Biotechnology; Cell and Molecular Biology of the Liver; Developmental Biology and Regeneration; Drug-induced Liver Disease; Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
1/30/2014Change of Grantee Organization (Type 7 Parent) (Summary) PA-14-078
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 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)
Gastroparesis Clinical Research Consortium

The GpCRC is focusing on the etiology, natural history, and therapy of gastroparesis. The goal of this consortium is to perform clinical, epidemiological, and therapeutic research in gastroparesis … (Summary)

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC … (Summary)

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 NIDDK Active Trials in Digestive Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.