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Digestive Diseases Genetics and Genomics

The Digestive Diseases Genetics and Genomics program supports research to identify genes that influence normal development, function, and diseases of the gastrointestinal tract.  The program supports research to identify genes that influence disease and related anatomical and physiological traits, as well as research on patterns and regulation of gene expression associated with these traits.  Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations.  Typical research approaches include genetic linkage, association, linkage-disequilibrium, exome sequencing, and whole-genome sequencing studies; QTL mapping, phenotype- and gene-driven mutagenesis screens; and macro- and microarray- and sequencing-based surveys of gene expression and epigenetic marks.​​

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 NIDDK Staff

 
Robert W. Karp, Ph.D.Genetics and Genomics of the GI Tract, Liver, Pancreas, Nutrition, and Obesity

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
2/12/2014Empirical Research on Ethical Issues Related to Central IRBs and Consent for Research Using Clinical Records and Data (R01) (Summary) RFA-OD-14-002
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 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)
Gastroparesis Clinical Research Consortium

The GpCRC is focusing on the etiology, natural history, and therapy of gastroparesis. The goal of this consortium is to perform clinical, epidemiological, and therapeutic research in gastroparesis … (Summary)

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Digestive Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.