U.S. Department of Health and Human Services
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Endocrine Pancreas

The Endocrine Pancreas program supports research on the basic biology, development, and function of the endocrine pancreas, as well as clinical studies on islet transplantation for the treatment of type 1 diabetes.  The research in this program includes developmental biology studies on tissue formation, particularly the development and regeneration of pancreatic islets, and basic biology studies on hormone synthesis and secretion from pancreatic endocrine cells (alpha, beta, delta, etc.) within the islet.  Areas addressing islet transplantation include studies on optimizing islet yield, viability, and durability in the procurement and pre-transplant process; enhancing islet graft survival and promoting immune tolerance of islet grafts; and evaluating transplantation alternatives to human islets.  ​​​​​​​​​​

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 NIDDK Staff

 
Guillermo A. Arreaza-Rubin, M.D.Diabetes and endocrine disease bioengineering and glucose sensingOlivier Blondel, Ph.D.Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic diseaseThomas Eggerman, M.D., Ph.D.Cystic fibrosis research and translation centers, clinical trials, and islet transplantation
Barbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in youth and adults; human studies of the effect of the intrauterine environment on subsequent development of metabolic disease in offspring.Sheryl Sato, Ph.D.Basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and diseaseJose Serrano, M.D., Ph.D.Liver Bioengineering and Biotechnology; Cell and Molecular Biology of the Liver; Developmental Biology and Regeneration; Drug-induced Liver Disease; Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
8/27/2014Consortium on Beta-cell Death and Survival (HIRN-CBDS) (UC4) (Summary) RFA-DK-14-021
8/26/2014Type 1 Diabetes Complications IMPACT Award (DP3) (Summary) RFA-DK-14-017
8/25/2014Identification of Novel Targets and Pathways Mediating Weight Loss, Diabetes Resolution and Related Metabolic Disease after Bariatric Surgery in Humans (R01) (Summary) RFA-DK-14-025
8/20/2014Limited Competition: Data Coordinating Center for Type 1 Diabetes TrialNet (UC4) (Summary) RFA-DK-14-507
8/15/2014Type 1 Diabetes TrialNet Clinical Centers (U01) (Summary) RFA-DK-14-016
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
(Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
(Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
(Summary)
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
(Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

(Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Type 1 Diabetes

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.