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Endocrine Tumors of the Pancreas

Pancreatic endocrine tumors (PETs) or pancreatic neuroendocrine tumors (PNETs) account for 1 percent to 10 percent of tumors arising in the pancreas, and represent a wide array of tumors that are mostly characterized by their secreted hormone, when functional.

The Endocrine Tumors of the Pancreas program supports research to understand the cellular and molecular physiology and pathophysiology of both functional and nonfunctional pancreatic tumors.  Research is aimed at identifying risk factors and diagnostic/prognostic molecular and laboratory markers, and includes studies on the epidemiology, clinical manifestations, and treatment of PETs.​

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 NIDDK Staff

 
Dana K. Andersen, M.D.Observational and Investigational Clinical Research; Biomedical Devices, Surgical Interventions, and Medications
Jose Serrano, M.D., Ph.D.Liver Bioengineering and Biotechnology; Cell and Molecular Biology of the Liver; Developmental Biology and Regeneration; Drug-induced Liver Disease; Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
5/2/2014Reagents for Glucagon and Incretin Research (R41/R42) (Summary) PA-14-204
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

 

SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

 

Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

 

The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

 

The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

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 NIDDK Active Trials in Pancreatic Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.