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Endocrinology and Hormone Signaling

The Endocrinology and Hormone Signaling program supports basic and clinical research on endocrinology, neuroendocrinology, hormone signaling, and nutrient sensing—with an emphasis on developing mechanistic insights into diabetes, obesity, and other endocrine-related health problems.  Studies include those that address the regulation of body composition; interactions between nutrition, exercise, and anabolic hormones; neural pathways and neuropeptides that regulate feeding behavior, satiety, and energy expenditure; the function and interaction of the hypothalamic-pituitary axis with peripheral metabolic signals; and the hormonal regulation of bone and mineral metabolism in health and disease.  Other studies address the structure and function of nuclear receptors and co-regulators and their regulation of gene expression; cellular mechanisms of glucose regulation; the intracellular signals that regulate cellular responses to insulin and other hormones; and the mechanisms and signaling pathways involved in nutrient sensing.  These studies are aimed at demonstrating how disruption of the pathways leads to the progression of metabolic disease.
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 NIDDK Staff

 
James Hyde, Ph.D.​Neurobiology of energy balance and body composition in obesity; diabetes centers; career development (“K”) programs
Saul Malozowski, M.D., Ph.D., M.B.A.Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism
Ronald N. Margolis, Ph.D.Signaling and gene expression by the nuclear receptor superfamily and their co-regulators,  as it relates to metabolism and metabolic diseaseCorinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/21/2014Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (UC4) (Summary) RFA-DK-14-024
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is … (Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
(Summary)
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program Outcomes Study is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of … (Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

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 NIDDK Active Trials in Endocrine Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.