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Endocrinology and Hormone Signaling

The Endocrinology and Hormone Signaling program supports basic and clinical research on endocrinology, neuroendocrinology, hormone signaling, and nutrient sensing—with an emphasis on developing mechanistic insights into diabetes, obesity, and other endocrine-related health problems.  Studies include those that address the regulation of body composition; interactions between nutrition, exercise, and anabolic hormones; neural pathways and neuropeptides that regulate feeding behavior, satiety, and energy expenditure; the function and interaction of the hypothalamic-pituitary axis with peripheral metabolic signals; and the hormonal regulation of bone and mineral metabolism in health and disease.  Other studies address the structure and function of nuclear receptors and co-regulators and their regulation of gene expression; cellular mechanisms of glucose regulation; the intracellular signals that regulate cellular responses to insulin and other hormones; and the mechanisms and signaling pathways involved in nutrient sensing.  These studies are aimed at demonstrating how disruption of the pathways leads to the progression of metabolic disease.
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 NIDDK Staff

 
James Hyde, Ph.D.Neurobiology of energy balance and body composition in obesity; diabetes centersSaul Malozowski, M.D., Ph.D., M.B.A.Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism
Ronald N. Margolis, Ph.D.Signaling and gene expression by the nuclear receptor superfamily and their co-regulators,  as it relates to metabolism and metabolic diseaseCorinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
4/22/2014Revisions to Add Biomedical Big Data Training to Active Institutional Training Grants (T32) (Summary) RFA-HG-14-005
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

 

SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

 

Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

 

The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

 

The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

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 NIDDK Active Trials in Endocrine Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.