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Endocrinology and Hormone Signaling

The Endocrinology and Hormone Signaling program supports basic and clinical research on endocrinology, neuroendocrinology, hormone signaling, and nutrient sensing—with an emphasis on developing mechanistic insights into diabetes, obesity, and other endocrine-related health problems.  Studies include those that address the regulation of body composition; interactions between nutrition, exercise, and anabolic hormones; neural pathways and neuropeptides that regulate feeding behavior, satiety, and energy expenditure; the function and interaction of the hypothalamic-pituitary axis with peripheral metabolic signals; and the hormonal regulation of bone and mineral metabolism in health and disease.  Other studies address the structure and function of nuclear receptors and co-regulators and their regulation of gene expression; cellular mechanisms of glucose regulation; the intracellular signals that regulate cellular responses to insulin and other hormones; and the mechanisms and signaling pathways involved in nutrient sensing.  These studies are aimed at demonstrating how disruption of the pathways leads to the onset and/or progression of metabolic disease.
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 NIDDK Staff

 
Carol Renfrew Haft, Ph.D. Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic diseaseJames Hyde, Ph.D.​Neurobiology of energy balance and body composition in obesity; diabetes centers; career development (“K”) programs
Saul Malozowski, M.D., Ph.D., M.B.A.Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism
Ronald N. Margolis, Ph.D.Signaling and gene expression by the nuclear receptor superfamily and their co-regulators,  as it relates to metabolism and metabolic diseaseCorinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
9/30/2014Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4) (Summary) RFA-DK-14-508
9/24/2014Nuclear Organization and Function Interdisciplinary Consortium (NOFIC)(U54) (Summary) RFA-RM-14-006
9/24/2014Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) (Summary) RFA-DK-14-026
9/4/2014Advancing Interventions to Improve Medication Adherence (R01) (Summary) PA-14-334
8/27/2014Consortium on Beta-cell Death and Survival (HIRN-CBDS) (UC4) (Summary) RFA-DK-14-021
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

(Summary)
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
(Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
(Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
(Summary)
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

(Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Endocrine Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.