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Erythropoiesis and Hemoglobin

The Erythropoiesis and Hemoglobin program supports work on the molecular and cellular biological pathways involved in erythroid cell differentiation.  This includes not only adult or definitive erythropoiesis (differentiation), but also ontological or primitive erythropoiesis (development).  Specific areas of interest include:  transcriptional, post-transcriptional, and translational regulation of erythroid-specific genes; mechanisms underlying normal and disordered globin gene regulation; heme biosynthesis and iron metabolism during erythropoiesis; erythroid cell membrane structure and function and the interaction of transport and receptor molecules; erythropoietin receptor signaling and its effects on gene regulation; mechanistic determinants of red blood cell survival; detection of abnormal hemoglobins; development of genetically targeted therapies for sickle cell anemia and thalassemias; and development of clinically applicable approaches for controlling fetal versus adult b-globin gene expression.​​

 NIDDK Staff

Terry Rogers Bishop, Ph.D.Hematology; Hematology Centers; Hematology Training


 Related Funding Opportunities

Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/3/2014NIDDK Cooperative Hematology Specialized Core Centers (U54) (Summary) RFA-DK-14-001
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
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 Research Resources

Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt6 LoxP (Sirt6 tm1.1Cxd) Mouse

Generation of floxed Sirtuin 6 for the construction of conditional knockout mice


The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases … (Summary)

Sirt1 LoxP (Sirt1 tm1Cxd) Mouse

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice


Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and … (Summary)

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.


The … (Summary)

Tg(MMTV-Cre)#Mam Mouse

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination … (Summary)

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 NIDDK Active Trials in Hematologic Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​​